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Cd44 Polymorphisms and Its Variants, As an Inconsistent Marker in Cancer Investigations Publisher Pubmed



Gomari MM1 ; Farsimadan M2 ; Rostami N3 ; Mahmoudi Z1 ; Fadaie M4 ; Farhani I5 ; Tarighi P1
Authors
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Authors Affiliations
  1. 1. Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran
  3. 3. Department of Chemical Engineering, Faculty of Engineering, Arak University, Iran
  4. 4. Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Medical Biotechnology, Faculty of Advanced Technologies in Medicine, Golestan University of Medical Sciences, Golestan, Iran

Source: Mutation Research - Reviews in Mutation Research Published:2021


Abstract

Among cell surface markers, CD44 is considered the main marker for identifying and isolating the cancer stem cells (CSCs) among other cells and has attracted significant attention in a variety of research areas. Many studies have shown the essential roles of CD44 in initiation, metastasis, and tumorigenesis in different types of cancer; however, the validity of CD44 as a therapeutic or diagnostic target has not been fully confirmed in some other studies. Whereas the association of specific single nucleotide polymorphisms (SNPs) in the CD44 gene and related variants with cancer risk have been observed in clinical investigations, the significance of these findings remains controversial. Here, we aimed to provide an up-to-date overview of recent studies on the association of CD44 polymorphisms and its variants with different kinds of cancer to determine whether or not it can be used as an appropriate candidate for cancer tracking. © 2021 Elsevier B.V.
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