Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Prognostic Value of Cd44 in Renal Cell Carcinoma



Kabiri M1 ; Sichani Mohammadi M1, 3 ; Taheri D2 ; Chehrei A2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Urology, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Urology, Al-Zahra Hospital, Isfahan, Iran

Source: Journal of Research in Medical Sciences Published:2006

Abstract

Background: CD44 is a transmembrane glycoprotein involved in cell-cell and cell-matrix interactions. De novo expression of CD44 and its variant isoforms has been associated with aggressive behavior in various tumors. Since little data is available on the role of CD44 expression in renal cell carcinoma, we evaluated CD44 expression to determine its prognostic value. Methods: Forty-six patients with renal cell carcinoma were studied. CD44 expression was evaluated semiquantitively on paraffin-embedded tumor tissue by immunohistochemistry. The prognostic value of CD44 was tested using Kaplan Meier plots by the log rank test and Cox regression analysis. Results: Fifteen out of 46 specimens (32.6%) were CD44-positive. According to bivariate analysis, tumor stage, tumor size, nuclear grade and CD44 expression were significant prognostic factors. Conclusions: CD44 expression can be considered as a useful prognostic parameter in renal cell carcinoma.
Related Docs
1. Immunohistochemical Distinction of Metastases of Renal Cell Carcinoma With Molecular Analysis of Overexpression of the Chemokines Cxcr2 and Cxcr3 As Independent Positive Prognostic Factors for the Tumorigenesis, IUBMB Life (2016)
2. Tumour Immune Microenvironment in Primary and Metastatic Papillary Renal Cell Carcinoma, Histopathology (2020)
3. Cd44 Polymorphisms and Its Variants, As an Inconsistent Marker in Cancer Investigations, Mutation Research - Reviews in Mutation Research (2021)
4. Molecular Biology, Genetic, and Epigenetics of Kidney Tumor, Genetics and Epigenetics of Genitourinary Diseases (2024)
5. Liquid Biopsy in Kidney Tumor, Liquid Biopsy in Urogenital Cancers and its Clinical Utility (2022)
6. Clear Cell Renal Cell Carcinoma: A Comprehensive in Silico Study in Searching for Therapeutic Targets, Kidney and Blood Pressure Research (2023)
7. Renal Cell Carcinoma Derived Exosome As Natural Nanoparticles Inhibits T Cell Proliferation and Induces Their Apoptosis, Nanomedicine Research Journal (2023)
Experts (# of related papers)
View all Related Experts
Babak Masoumi (1)
Alieh Gholaminejad (1)