Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Association Between Calcium Intake and Prostate Neoplasm; a Systematic Review and Meta-Analysis Publisher



Asgari Savadjani S1 ; Yadollahi F2 ; Maghsoudi A3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
  2. 2. Department of Internal Medicine, School of Medicine, Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran
  3. 3. Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Nephropathology Published:2024


Abstract

Introduction: Prostate cancer is the second leading cause of cancer death, and the present systematic review and meta-analysis aimed to investigate the effect of calcium use on the risk of prostate cancer. Materials and Methods: The current systematic review and meta-analysis used the PRISMA checklist. The search was conducted using databases, including Web of Science, Cochrane, ProQuest, PubMed, and Google Scholar Search Engine, without a time limit until November 22, 2023. The obtained data was analyzed using STATA 14 software. Results: The results obtained from combining 28 observational studies and clinical trials indicated that calcium increased the risk of prostate cancer (OR: 1.10, 95% CI: 1.06, 1.13). On the other hand, cohort (OR: 1.08, 95% CI: 1.06, 1.13), cross-control (OR: 1.04, 95% CI: 0.96, 1.14), cross-sectional (OR: 1.06, 95% CI: 0.86, 1.29), and randomized controlled trial (OR: 1.21, 95% CI: 1.06, 1.39) studies indicated a relationship between calcium use and risk of prostate malignancy. Furthermore, calcium increased the risk of prostate cancer in the age group 50 to 59 years (OR: 1.16, 95% CI: 1.09, 1.24), however no considerable association was noticed between calcium administration and prostate cancer in the age group 60 to 69 years (OR: 1.03, 95% CI: 0.94, 1.13). The risk of prostate cancer in individuals who used less than 1300 mg calcium per day, those who used 1300 – 2000 mg/d, and those who taken more than 2000 mg calcium per day were (OR: 1.04, 95% CI: 1, 1.09), (OR: 1.17, 95% CI: 1.09, 1.26), and (OR: 1.29, 95% CI: 1.13, 1.48), respectively. Conclusion: Generally, calcium administration increases the risk of prostate cancer in men by 10%, and the risk is enhanced with the increase in dosage of calcium. Registration: This study has been compiled based on the PRISMA checklist, and its protocol was registered on the PROSPERO (ID=CRD42023489091) and Research Registry (UIN: reviewregistry1787) website. © 2024 The Author(s).
Related Docs
View other Related Docs
1. Association Between Nut Consumption and Prostate Cancer Risk in Adults: A Systematic Review and Dose-Response Meta-Analysis of Observational Studies, Nutrition, Metabolism and Cardiovascular Diseases (2023)
2. Association Between Red and Processed Meat Consumption and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis, Frontiers in Nutrition (2022)
3. Total, Dietary, and Supplemental Calcium Intake and Risk of All-Cause Cardiovascular, and Cancer Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies, Critical Reviews in Food Science and Nutrition (2022)
4. Total, Dietary, and Supplemental Calcium Intake and Mortality From All-Causes, Cardiovascular Disease, and Cancer: A Meta-Analysis of Observational Studies, Nutrition, Metabolism and Cardiovascular Diseases (2015)
5. The Burden of Prostate Cancer in North Africa and Middle East, 1990–2019: Findings From the Global Burden of Disease Study, Frontiers in Oncology (2022)
6. Fish Consumption and Risk of Prostate Cancer or Its Mortality: An Updated Systematic Review and Dose–Response Meta-Analysis of Prospective Cohort Studies, Frontiers in Nutrition (2023)
7. The Association Between Dietary Diversity Score and Risk of Prostate Cancer: (A Case-Control Study), Nutrition and Cancer (2022)
8. The Neutrophil-To-Lymphocyte Ratio As a New Prognostic Factor in Cancers: A Narrative Review, Frontiers in Oncology (2023)
Experts (# of related papers)
View all Related Experts
Omid Sadeghi (5)
Gholamreza Askari (4)
Other Related Docs
9. Burden of Thyroid Cancer in North Africa and Middle East 1990–2019, Frontiers in Oncology (2022)
10. Determination of Prostate Cancer Risk Factors in Isfahan, Iran: A Case-Control Study., Medicinski arhiv (2012)
11. Pseudomonas Exotoxin-Based Immunotoxins: Over Three Decades of Efforts on Targeting Cancer Cells With the Toxin, Frontiers in Oncology (2021)
12. The Incidence and Mortality of Prostate Cancer and Its Relationship With Development in Asia, Prostate International (2015)
13. Associations Between Dietary Inflammatory Index and Incidence of Breast and Prostate Cancer: A Systematic Review and Meta-Analysis, Nutrition (2018)
14. Total, Dietary, and Supplemental Magnesium Intakes and Risk of All-Cause, Cardiovascular, and Cancer Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies, Advances in Nutrition (2021)
15. Determinants of Quality of Life in Breast Cancer: Meta-Analytic Structural Equation Modeling of Studies, European Journal of Cancer Care (2023)
16. Breast Cancer Screening and Early Detection Programs in Iran: A Health Policy Analysis and Recommendations, World Medical and Health Policy (2024)
17. Dietary Calcium Intake in Relation to Blood Lipids and Lipoproteins Profiles: A Systematic Review and Meta-Analysis of Epidemiologic Studies, Nutrition, Metabolism and Cardiovascular Diseases (2022)
18. Transitional Epidemiology of Human Papillomavirus Infection in Iran: A Cross‑Sectional Study and National Review, Advanced Biomedical Research (2023)
19. Association Between the Length of a Ca Dinucleotide Repeat in the C-Src Gene and Risk of Prostate Cancer, Journal of Isfahan Medical School (2018)
20. Association Between Calcium Intake and Risk of Breast Cancer: An Updated Systematic Review and Dose–Response Meta-Analysis of Cohort Studies, Clinical Nutrition ESPEN (2023)
21. The Risk Factors of Prostate Cancer: A Multicentric Case-Control Study in Iran, Asian Pacific Journal of Cancer Prevention (2007)
22. Symptomatic Metastasis Prediction With Serial Measurements of Ca 15.3 in Primary Breast Cancer Patients, Journal of Research in Medical Sciences (2012)
23. Dietary Intake and Biomarkers of Linoleic Acid and Risk of Prostate Cancer in Men: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies, Critical Reviews in Food Science and Nutrition (2024)
24. Effect of the Number of Negative Lymph Nodes Removed on the Survival and Recurrence Rate After Primary Surgery in Patients With Ovarian Cancer: A Multi-Center Retrospective Cohort Study, Indian Journal of Surgical Oncology (2024)
25. Dietary Approach to Stop Hypertension (Dash): Diet Components May Be Related to Lower Prevalence of Different Kinds of Cancer: A Review on the Related Documents, Journal of Research in Medical Sciences (2015)
26. Investigating the Probable Potential of Dihydropyridine Calcium Channel Blockers: Drug Repositioning in Cancer, Current Cancer Therapy Reviews (2024)
27. Treatment of Hormone Resistance With Docetaxel in Metastatic Prostate Cancer Patients: Results of a Clinical Experience at Omid Hospital, Isfahan, Iran, Middle East Journal of Cancer (2017)
28. Calcium and Dairy Products in the Chemoprevention of Colorectal Adenomas: A Systematic Review and Meta-Analysis, Critical Reviews in Food Science and Nutrition (2022)
29. Investigation of Prostate Disorders in 614 Patients Attended Alzahra/Urology Ward Between the Years 2013 to 2015 in Isfahan, International Journal of Pharmaceutical and Clinical Research (2016)
30. Impact of Analgesics on the Risk of Ovarian Cancer; a Systematic Review and Meta-Analysis of Cohort and Case-Control Studies, Immunopathologia Persa (2025)
31. Dietary Calcium Intake in Relation to Metabolic Syndrome in Adults: A Systematic Review and Dose–Response Meta-Analysis of Epidemiological Studies With Grade Assessment, Obesity Reviews (2025)
32. Trichomonas Vaginalis Infection and Risk of Cervical Neoplasia: A Systematic Review and Meta-Analysis, PLoS ONE (2023)
33. Effect of Androgen Deprivation Therapy on Cardiovascular Risk Factors in Prostate Cancer, Journal of Research in Medical Sciences (2013)
34. Burden of Breast Cancer and Attributable Risk Factors in the North Africa and Middle East Region, 1990–2019: A Systematic Analysis for the Global Burden of Disease Study 2019, Frontiers in Oncology (2023)
35. Unfavorable Prognosis and Clinical Consequences of Apobec3b Expression in Breast and Other Cancers: A Systematic Review and Meta-Analysis, Tumor Biology (2022)
36. Curcumin for the Treatment of Prostate Diseases: A Systematic Review of Controlled Clinical Trials, Advances in Experimental Medicine and Biology (2021)
37. Lycopene Does Not Affect Prostate-Specific Antigen in Men With Non-Metastatic Prostate Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Nutrition and Cancer (2021)
38. The Association Between Dietary Calcium Intake and Breast Cancer Risk Among Iranian Women, Nutrition and Cancer (2022)