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Nucleic Acid-Based Therapeutics for Dermal Wound Healing Publisher Pubmed



Sharma P1, 2 ; Kumar A1 ; Agarwal T3 ; Dey AD1 ; Moghaddam FD4 ; Rahimmanesh I5 ; Ghovvati M6 ; Yousefiasl S7 ; Borzacchiello A8 ; Mohammadi A9 ; Yella VR3 ; Moradi O10 ; Sharifi E11
Authors
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Authors Affiliations
  1. 1. Chitkara College of Pharmacy, Chitkara University, Punjab, India
  2. 2. Government Pharmacy College Kangra, Nagrota Bhagwan, Himachal Pradesh, India
  3. 3. Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Vaddeswaram, AP, India
  4. 4. Institute for Photonics and Nanotechnologies, National Research Council, Via Fosso del Cavaliere, 100, Rome, 00133, Italy
  5. 5. Applied Physiology Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, 8174673461, Iran
  6. 6. Department of Radiological Sciences, David Geffen School of Medicine, University of California – Los Angeles, Los Angeles, 90095, CA, United States
  7. 7. School of Dentistry, Hamadan University of Medical Sciences, Hamadan, 6517838736, Iran
  8. 8. Institute for Polymers, Composites, and Biomaterials (IPCB), National Research Council (CNR), Naples, 80125, Italy
  9. 9. Department of Chemistry, University of Isfahan, Isfahan, 81746-73441, Iran
  10. 10. Department of Chemistry, Islamic Azad University, Shahr-e-Qods Branch, Tehran, 374-37515, Iran
  11. 11. Department of Tissue Engineering and Biomaterials, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, 6517838736, Iran

Source: International Journal of Biological Macromolecules Published:2022


Abstract

Non-healing wounds have long been the subject of scientific and clinical investigations. Despite breakthroughs in understanding the biology of delayed wound healing, only limited advances have been made in properly treating wounds. Recently, research into nucleic acids (NAs) such as small-interfering RNA (siRNA), microRNA (miRNA), plasmid DNA (pDNA), aptamers, and antisense oligonucleotides (ASOs) has resulted in the development of a latest therapeutic strategy for wound healing. In this regard, dendrimers, scaffolds, lipid nanoparticles, polymeric nanoparticles, hydrogels, and metal nanoparticles have all been explored as NA delivery techniques. However, the translational possibility of NA remains a substantial barrier. As a result, different NAs must be identified, and their distribution method must be optimized. This review explores the role of NA-based therapeutics in various stages of wound healing and provides an update on the most recent findings in the development of NA-based nanomedicine and biomaterials, which may offer the potential for the invention of novel therapies for this long-term condition. Further, the challenges and potential for miRNA-based techniques to be translated into clinical applications are also highlighted. © 2022 Elsevier B.V.
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