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Mirna-Encapsulated Abiotic Materials and Biovectors for Cutaneous and Oral Wound Healing: Biogenesis, Mechanisms, and Delivery Nanocarriers Publisher



Deka Dey A1 ; Yousefiasl S2 ; Kumar A1 ; Dabbagh Moghaddam F3, 4 ; Rahimmanesh I5 ; Samandari M6 ; Jamwal S7 ; Maleki A8, 9, 10 ; Mohammadi A11 ; Rabiee N12, 13 ; Claudia Paivasantos A15 ; Tamayol A6 ; Sharifi E16 ; Makvandi P17, 18
Authors
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Authors Affiliations
  1. 1. Chitkara College of Pharmacy, Chitkara University, Punjab, India
  2. 2. School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran
  3. 3. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
  4. 4. Institute for Photonics and Nanotechnologies, National Research Council, Via Fosso del Cavaliere, 100, Rome, Italy
  5. 5. Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Biomedical Engineering, University of Connecticut, Farmington, CT, United States
  7. 7. Department of Psychiatry, Yale School of Medicine, Yale University, New Haven, CT, United States
  8. 8. Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
  9. 9. Zanjan Pharmaceutical Nanotechnology Research Center (ZPNRC), Zanjan University of Medical Sciences, Zanjan, Iran
  10. 10. Cancer Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  11. 11. Department of Chemistry, University of Isfahan, Isfahan, Iran
  12. 12. Department of Physics, Sharif University of Technology, Tehran, Iran
  13. 13. School of Engineering, Macquarie University, Sydney, NSW, Australia
  14. 14. Department of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Coimbra, Portugal
  15. 15. LAQV, REQUIMTE, Department of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Coimbra, Portugal
  16. 16. Department of Tissue Engineering and Biomaterials, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran
  17. 17. Istituto Italiano di Tecnologia, Centre for Materials Interfaces, Pontedera, Italy
  18. 18. School of Chemistry, Damghan University, Damghan, Iran

Source: Bioengineering and Translational Medicine Published:2023


Abstract

MicroRNAs (miRNAs) as therapeutic agents have attracted increasing interest in the past decade owing to their significant effectiveness in treating a wide array of ailments. These polymerases II-derived noncoding RNAs act through post-transcriptional controlling of different proteins and their allied pathways. Like other areas of medicine, researchers have utilized miRNAs for managing acute and chronic wounds. The increase in the number of patients suffering from either under-healing or over-healing wound demonstrates the limited efficacy of the current wound healing strategies and dictates the demands for simpler approaches with greater efficacy. Various miRNA can be designed to induce pathway beneficial for wound healing. However, the proper design of miRNA and its delivery system for wound healing applications are still challenging due to their limited stability and intracellular delivery. Therefore, new miRNAs are required to be identified and their delivery strategy needs to be optimized. In this review, we discuss the diverse roles of miRNAs in various stages of wound healing and provide an insight on the most recent findings in the nanotechnology and biomaterials field, which might offer opportunities for the development of new strategies for this chronic condition. We also highlight the advances in biomaterials and delivery systems, emphasizing their challenges and resolutions for miRNA-based wound healing. We further review various biovectors (e.g., adenovirus and lentivirus) and abiotic materials such as organic and inorganic nanomaterials, along with dendrimers and scaffolds, as the delivery systems for miRNA-based wound healing. Finally, challenges and opportunities for translation of miRNA-based strategies into clinical applications are discussed. © 2022 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers.
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