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Clinical Phenotype and Disease Course of Inflammatory Bowel Disease in Iran: Results of the Iranian Registry of Crohn's and Colitis (Ircc) Publisher Pubmed



Saberzadehardestani B1 ; Khosravi AA1 ; Mansourghanaei F2 ; Vahedi H1 ; Baniasadi N3 ; Seyyedmajidi M4 ; Parhizkar B5 ; Hormati A1 ; Naghshbandi SJ5 ; Matin S6, 7 ; Zadeh AAH8 ; Taghvaei T9 ; Bahrami M10 ; Rafeey M11 Show All Authors
Authors
  1. Saberzadehardestani B1
  2. Khosravi AA1
  3. Mansourghanaei F2
  4. Vahedi H1
  5. Baniasadi N3
  6. Seyyedmajidi M4
  7. Parhizkar B5
  8. Hormati A1
  9. Naghshbandi SJ5
  10. Matin S6, 7
  11. Zadeh AAH8
  12. Taghvaei T9
  13. Bahrami M10
  14. Rafeey M11
  15. Ahadi M12
  16. Vossoughinia H12
  17. Muosavi H10
  18. Gheibi S13
  19. Hosseinihemmatabadi RS14
  20. Yazdanbod A15
  21. Matinkhah S16
  22. Esmaeili FS5
  23. Fakheri H9
  24. Moosavy SH17
  25. Maleki I9
  26. Nasserimoghaddam S1
  27. Khosravi B1
  28. Farahmand F18
  29. Najafi M19
  30. Alimadadi H20
  31. Malekzadeh M1
  32. Anushiravani A1
  33. Kasaeian A21, 22, 23
  34. Alatab S1
  35. Sadeghi A1
  36. Radmard AR24
  37. Kolahdoozan S1
  38. Rajabi Z25
  39. Sima AR1, 10
Show Affiliations
Authors Affiliations
  1. 1. Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Guilan, Iran
  3. 3. Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran
  4. 4. Golestan Research Center of Gastroenterology, Golestan University of Medical Science, Gorgan, Iran
  5. 5. Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
  6. 6. Department of Internal Medicine, School of Medicine, Lung Diseases Research Center, Ardabil, Iran
  7. 7. Digestive Diseases Research Center, Imam Khomeini Hospital, Ardabil University of Medical Sciences, Ardabil, Iran
  8. 8. Nazeran Hospital, Mashhad, Iran
  9. 9. Gut and Liver Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
  10. 10. Sasan Alborz Biomedical Research Center, Masoud Gastroenterology and Hepatology Center, Tehran, Iran
  11. 11. Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  12. 12. Department of Gastroenterology and Hepatology, Mashhad University of Medical Sciences, Mashhad, Iran
  13. 13. Maternal and Childhood Obesity Research center, Urmia University of Medical Sciences, Urmia, Iran
  14. 14. Shahid Sadoughi University, Yazd, Iran
  15. 15. Digestive Disease Research Center, Ardabil University of Medical Science, Ardabil, Iran
  16. 16. Isfahan University of Medical Sciences, Isfahan, Iran
  17. 17. Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
  18. 18. Pediatric Gastroenterology and Hepatology in Children Research Center, Tehran University of Medical Sciences, Tehran, Iran
  19. 19. Tehran University of Medical Sciences, Tehran, Iran
  20. 20. Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran
  21. 21. Digestive Oncology Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  22. 22. Research Center for Chronic Inflammatory Diseases, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  23. 23. Clinical Research Development Unit, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  24. 24. Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  25. 25. Department of Internal Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Archives of Iranian Medicine Published:2024


Abstract

Background: Data on the epidemiology of inflammatory bowel disease (IBD) in the Middle East are scarce. We aimed to describe the clinical phenotype, disease course, and medication usage of IBD cases from Iran in the Middle East. Methods: We conducted a cross-sectional study of registered IBD patients in the Iranian Registry of Crohn's and Colitis (IRCC) from 2017 until 2022. We collected information on demographic characteristics, past medical history, family history, disease extent and location, extra-intestinal manifestations, IBD medications, and activity using the IBD-control-8 questionnaire and the Manitoba IBD index, admissions history, history of colon cancer, and IBD-related surgeries. Results: In total, 9746 patients with ulcerative colitis (UC) (n = 7793), and Crohn's disease (CD) (n = 1953) were reported. The UC to CD ratio was 3.99. The median age at diagnosis was 29.2 (IQR: 22.6,37.6) and 27.6 (IQR: 20.6,37.6) for patients with UC and CD, respectively. The male-to-female ratio was 1.28 in CD patients. A positive family history was observed in 17.9% of UC patients. The majority of UC patients had pancolitis (47%). Ileocolonic involvement was the most common type of involvement in CD patients (43.7%), and the prevalence of stricturing behavior was 4.6%. A prevalence of 0.3% was observed for colorectal cancer among patients with UC. Moreover,15.2% of UC patients and 38.4% of CD patients had been treated with anti-tumor necrosis factor (anti-TNF). Conclusion: In this national registry-based study, there are significant differences in some clinical phenotypes such as the prevalence of extra-intestinal manifestations and treatment strategies such as biological use in different geographical locations. © 2024 Academy of Medical Sciences of I.R. Iran. All rights reserved.
8. Irritable Bowel Syndrome in Iran: Sepahan Systematic Review No. 1, International Journal of Preventive Medicine (2012)
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