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Causes of Colectomy in Patients With Ulcerative Colitis: Findings From an Iranian National Registry Publisher Pubmed



Sanat ZM1 ; Vahedi H1 ; Malekzadeh R1 ; Kasaeian A2, 3, 4 ; Ganjaroudi NM5 ; Sima A6 ; Ghanaei FM7 ; Ghadir M8 ; Fakheri HT9 ; Moghaddam SN1 ; Alatab S1 ; Sadeghi A1 ; Anushiravani A1 ; Maleki I9 Show All Authors
Authors
  1. Sanat ZM1
  2. Vahedi H1
  3. Malekzadeh R1
  4. Kasaeian A2, 3, 4
  5. Ganjaroudi NM5
  6. Sima A6
  7. Ghanaei FM7
  8. Ghadir M8
  9. Fakheri HT9
  10. Moghaddam SN1
  11. Alatab S1
  12. Sadeghi A1
  13. Anushiravani A1
  14. Maleki I9
  15. Yazdanbod A10
  16. Vossoughinia H11
  17. Seyyedmajidi M12
  18. Naghshbandi SJ13
  19. Baniasadi N14
  20. Parhizkar B13
  21. Matinkhah S15
  22. Gheibi S16
  23. Hosseini Hemmat Abadi RS17
  24. Toosi SV9
Show Affiliations
Authors Affiliations
  1. 1. Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Digestive Oncology Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Research Center for Chronic Inflammatory Diseases, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Clinical Research Development Unit, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Sasan Alborz Biomedical Research Center, Masoud Gastroenterology and Hepatology Center, Tehran, Iran
  7. 7. Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Guilan, Iran
  8. 8. Gastroenterology and Hepatology Diseases Research Center, Qom University of Medical Science, Qom, Iran
  9. 9. Gut and Liver Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
  10. 10. Digestive Diseases Research Center, Ardabil University of Medical Sciences, Ardabil, Iran
  11. 11. Department of Gastroenterology and Hepatology, Mashhad University of Medical Sciences, Mashhad, Iran
  12. 12. Golestan Research Center of Gastroenterology, Golestan University of Medical Science, Gorgan, Iran
  13. 13. Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
  14. 14. Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran
  15. 15. Isfahan University of Medical Sciences, Isfahan, Iran
  16. 16. Maternal and Childhood Obesity Research center, Urmia University of Medical Sciences, Urmia, Iran
  17. 17. Shahid Sadoughi University, Yazd, Iran

Source: Archives of Iranian Medicine Published:2024


Abstract

Background: Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD) marked by rectal and colon inflammation, leading to relapsing symptoms. Its prevalence is increasing, particularly in developed nations, impacting patients’ health. While its exact cause remains unclear, genetic and environmental factors are implicated, elevating the risk of colorectal cancer (CRC). Colectomy, though declining, is still performed in select UC cases, necessitating further study. Methods: We analyzed data from the Iranian Registry of Crohn’s and Colitis (IRCC) to examine UC patients undergoing colectomy. We collected demographic and clinical data from 91 patients, focusing on dysplasia. Statistical analyses assessed dysplasia risk factors. Results: Patients with dysplasia were older at diagnosis and surgery compared to those without dysplasia. Age emerged as a significant risk factor for dysplasia in UC patients undergoing colectomy. No significant associations were found between dysplasia and other factors. Conclusion: Age plays a crucial role in dysplasia risk among UC patients undergoing colectomy. Older age at diagnosis and surgery may indicate a higher risk of dysplasia and CRC. Clinicians should consider age when managing UC patients and implementing screening protocols. Further research with larger samples is needed to confirm these findings. © 2024 Academy of Medical Sciences of I.R. Iran. All rights reserved.
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