Long Non-Coding Rna Miat Mediates Cross-Talk Between the Kidneys and Hippocampus in the Rat Model of Acute Kidney Injury

Long Non-Coding Rna Miat Mediates Cross-Talk Between the Kidneys and Hippocampus in the Rat Model of Acute Kidney Injury Publisher

Malek M¹ ; Mohammadtaheri F² ; Nikpour P³ ; Baradaran A⁴

Show Affiliations

1. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2. Department of Genetics, Faculty of Basic Sciences, Shahrekord University, Shahrekord, Iran
3. Department of Genetics and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4. Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Physiology and Pharmacology (Iran) Published:2020

Abstract

Introduction: The role of long noncoding RNAs (IncRNAs) has been intensively studied in the development of several human diseases. Myocardial infarctionassociated transcript (Miat) is among the most abundant and highly conserved lncRNAs that exhibits deregulation in some critical diseases. However, it remains unclear whether Miat may also play a role in the pathogenesis of acute kidney injury (AKI) and neurological consequences. Methods: In the present study, the expression of lncRNA Miat was measured in the rat kidney and hippocampus tissues to assess if there is an association between the expression of it and AKI. AKI was induced by clamping the bilateral renal artery for 45min and was confirmed 24 hours after reperfusion by biochemical markers and histopathological assessments in rat kidneys. Results: We observed an increasing trend of Miat expression (256-fold) in the kidney as well as the hippocampus (2-fold) following AKI. Conclusion: It appears that there is a relationship between the deregulation of the Miat expression and AKI and the hippocampal involvement, although more studies are needed to confirm the functional effect of this lncRNA in AKI. © 2020, Iranian Society of Physiology and Pharmacology. All rights reserved.

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Style	Citing Format
MLA	Malek M, et al.. "Long Non-Coding Rna Miat Mediates Cross-Talk Between the Kidneys and Hippocampus in the Rat Model of Acute Kidney Injury." Physiology and Pharmacology (Iran), vol. 24, no. 1, 2020, pp. 1-9.
APA	Malek M, Mohammadtaheri F, Nikpour P, Baradaran A (2020). Long Non-Coding Rna Miat Mediates Cross-Talk Between the Kidneys and Hippocampus in the Rat Model of Acute Kidney Injury. Physiology and Pharmacology (Iran), 24(1), 1-9.
Chicago	Malek M, Mohammadtaheri F, Nikpour P, Baradaran A. "Long Non-Coding Rna Miat Mediates Cross-Talk Between the Kidneys and Hippocampus in the Rat Model of Acute Kidney Injury." Physiology and Pharmacology (Iran) 24, no. 1 (2020): 1-9.
Harvard	Malek M et al. (2020) 'Long Non-Coding Rna Miat Mediates Cross-Talk Between the Kidneys and Hippocampus in the Rat Model of Acute Kidney Injury', Physiology and Pharmacology (Iran), 24(1), pp. 1-9.
Vancouver	Malek M, Mohammadtaheri F, Nikpour P, Baradaran A. Long Non-Coding Rna Miat Mediates Cross-Talk Between the Kidneys and Hippocampus in the Rat Model of Acute Kidney Injury. Physiology and Pharmacology (Iran). 2020;24(1):1-9.
BibTex	@article{ author = {Malek M and Mohammadtaheri F and Nikpour P and Baradaran A}, title = {Long Non-Coding Rna Miat Mediates Cross-Talk Between the Kidneys and Hippocampus in the Rat Model of Acute Kidney Injury}, journal = {Physiology and Pharmacology (Iran)}, volume = {24}, number = {1}, pages = {1-9}, year = {2020} }
RIS	TY - JOUR AU - Malek M AU - Mohammadtaheri F AU - Nikpour P AU - Baradaran A TI - Long Non-Coding Rna Miat Mediates Cross-Talk Between the Kidneys and Hippocampus in the Rat Model of Acute Kidney Injury JO - Physiology and Pharmacology (Iran) VL - 24 IS - 1 SP - 1 EP - 9 PY - 2020 ER -

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