Apoptosis and Myocardial Infarction: Role of Ncrnas and Exosomal Ncrnas Publisher Pubmed



Farokhian A¹ ; Rajabi A^{2, 3} ; Sheida A^{2, 3} ; Abdoli A^{2, 3} ; Rafiei M^{2, 3} ; Jazi ZH^{2, 3} ; Asouri SA⁴ ; Morshedi MA^{2, 3} ; Hamblin MR⁵ ; Adibhajbagheri P⁶ ; Mirzaei H⁴ Show Affiliations
Source: Epigenomics Published:2023

Abstract

ncRNAs, particularly miRNAs, lncRNAs and circRNAs, are a group of RNAs which, although they do not encode proteins (however, recent evidence shows that certain circRNAs are translatable), play a major role in regulating gene expression and, therefore, affect multiple cellular processes, in particular apoptosis. Apoptosis is proven to mediate myocardial infarction physiopathology in addition to ischemic necrosis and, therefore, has recently gained great interest as a target to improve MI outcomes. The current work reviews studies that have assessed ncRNAs with the ability to promote or suppress apoptosis in the process of MI and, therefore, may introduce new therapeutic targets for MI treatment. © 2023 Future Medicine Ltd.