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Phaeohyphomycosis Caused by Neoscytalidium Dimidiatum in a Covid-19 Patient; [Feohifomicosis Producida Por Neoscytalidium Dimidiatum En Un Paciente Con Covid-19] Publisher Pubmed



Dolatabadi S1 ; Nasirharandi S2 ; Pourahmad M3 ; Ahmadikia K4 ; Mokhtari M5 ; Najafzadeh MJ6 ; Mohammadi R7
Authors
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Authors Affiliations
  1. 1. Department of Biology, Hakim Sabzevari University, Sabzevar, Iran
  2. 2. Department of Infectious Diseases, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Department of Medical Parasitology and Mycology, School of Medicine, Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Revista Iberoamericana de Micologia Published:2022


Abstract

Background: Neoscytalidium dimidiatum is an opportunistic dematiaceous fungus belonging to the class Dothideomycetes. Case report: We report a case of N. dimidiatum cerebral phaeohyphomycosis post COVID-19 infection in a 32-year-old male from Iran. The causative agent was identified by cytopathology, routine mycological methods, and DNA sequencing of the internal transcribed spacer (ITS) region of rDNA. Apart from COVID-19 complications and the corticosteroid therapy, no underlying condition was diagnosed. The symptoms suggesting the fungal infection were shown two weeks after being discharged from COVID-19 hospital stay. Magnetic resonance of the brain showed a multi-focal central nervous system infection. The delayed identification of the fungus and, thus, a late starting of the antifungal treatment with amphotericin B, might have affected the patient outcome as he finally died. Conclusions: Considering the rare incidence of N. dimidiatum infections, this case should aware us about them, leading to a timely antifungal management. © 2022
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