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Case Series of Rhinocerebral Mucormycosis Occurring in Diabetic Patients



Mohammadi R1 ; Meidani M2 ; Mostafavizadeh K2 ; Iraj B3 ; Hamedani P3 ; Sayedain SMA4 ; Mokhtari M1
Authors
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Authors Affiliations
  1. 1. Department of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Infectious Diseases, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Endocrinology, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Cardiology, Chamran Hospital (Heart Center), Isfahan University of Medical Sciences, Isfahan, Iran

Source: Caspian Journal of Internal Medicine Published:2015

Abstract

Background: Rhinocerebral mucormycosis is a fatal infection typically affecting diabetic or immunosuppressed patients. In most cases, infection is caused by inhalation of fungal spores. Mortality rate of patients is very high (40-85%). Case Presentation: In this study, three diabetic patients with rhinocerebral mucormycosis were presented. The etiologic agents of mucormycosis in two patients were isolated and identified by sequence analysis and data were registered in Gene bank database. Conclusion: In patients with mucoreosis, early detection, surgical excision and appropriate debridement, suitable antifungal therapy, and control of risk factors like diabetes mellitus are the main parameters of successful management of this lethal infection. Keywords: Rhinocerebral mucormycosis, Diabetes Mellitus, Iran.
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