Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effectiveness of Twice Weekly Iron Supplementation Compared With Daily Regimen in Reducing Anemia and Iron Deficiency During Pregnancy: A Randomized Trial in Iran



Zamani AR1 ; Farajzadegan Z1 ; Ghahiri A2 ; Khademloo M3 ; Golshiri P4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Community Medicine Department, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Obstetric and Gynecologic Department, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Community Medicine Department, Sari University of Medical Sciences, Sari, Iran
  4. 4. Public Health School, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Research in Medical Sciences Published:2008

Abstract

Background: Over 40 millions pregnant women are suffering from iron deficiency (ID) and it's consequences in developing countries presently. If the effects of twice weekly iron supplementation on hemoglobin (Hb) and serum ferritin (SF) to be shown comparable to daily iron supplementation in pregnancy, it will reduce the cost, will diminish the side effects, will increase the compliance and will prevent the potential harmful effects of extra iron supplement. Methods: A total of 152 pregnant women were enrolled in the study in two different clinics in Isfahan, Iran. The inclusion criteria were 2nd trimester pregnant women aged between 18-38 years with the initial Hb ≥ 110 g/L. They were randomized into two treatment groups, either the twice weekly (TW) taking iron group (two 45-mg ferrous sulfate tablets per week) or daily taking iron group (45 mg ferrous sulfate tablet). The age, weight, education and employment status of pregnant women along with their parity distributions and gestational age at onset of treatment in the two groups were comparable. Sixty nine and fifty three pregnant women of daily group and TW group, respectively, could be followed up regularly at 4 weekly intervals until 16 weeks of supplementation. Side effects, compliance and the number of tablets consumed were noted for each group. Blood was sampled at 15-16 and 37-39 weeks of pregnancy and blood indices were evaluated to see the effect of iron supplementation. Results: The mean initial Hb concentrations were 133 ± 11 g/L and 130 ± 12 g/L in daily and TW groups, respectively, which were not significant. The mean final Hb concentrations were 127 ± 15 g/L in daily group and 120 ± 13 g/L in TW group (p < 0.05). The decrease of Hb from the start to the end of therapy was significant in both groups and the decrements significantly were less in daily group. The SF increased non-significantly in daily group and decreased nonsignificantly in TW group but, there was no difference in ferritin values of the two groups at near term. Conclusions: Daily regimen was more effective than TW regimen in preventing Hb decrement at near term in our study.
Related Docs
View other Related Docs
1. The Effect of Simultaneous Administration of Zinc Sulfate and Ferrous Sulfate in the Treatment of Anemic Pregnant Women, Journal of Research in Medical Sciences (2005)
2. Diagnostic Performance and Discriminative Value of the Serum Ferritin Level for Predicting Preterm Labor, Journal of Research in Medical Sciences (2012)
3. Evaluation of the Prevalence and Determinants of Iron Deficiency Anemia in a Sample of Preschool-Aged Children in Isfahan City, Iran, Journal of Isfahan Medical School (2017)
4. The Effect of Iron-Vitamin C Co-Supplementation on Biomarkers of Oxidative Stress in Iron-Deficient Female Youth, Biological Trace Element Research (2013)
5. Efficacy and Safety of Iranian Made Deferasirox (Osveral®)In Iranian Major Thalassemic Patients With Transfusional Iron Overload: A One Year Prospective Multicentric Open-Label Non-Comparative Study, DARU, Journal of Pharmaceutical Sciences (2011)
6. Iron and Zinc Nutritional and Biochemical Status and Their Relationship Among Child Bearing Women in Marand Province, Pakistan Journal of Nutrition (2007)
7. Evaluation of Iron Status by Serum Ferritin Level in Iranian Carriers of Beta Thalassemia Minor, International Journal for Vitamin and Nutrition Research (2008)
8. Prevalence of Anemia According to Some Hematological Parameters Among Reproductive-Age Females in Kermanshah, Western Iran, Journal of Nutrition and Food Security (2019)
Experts (# of related papers)
View all Related Experts
Roya Kelishadi (4)
Zamzam Paknahad (3)
Other Related Docs
9. Investigation and Comparison of G6pd Enzyme Screening Test Costs for All Newborns With Treatment Costs of Patients With Favism Admitted Due to Hemolysis; [Ispitivanje I Uporedivanje Troskova G6pd Enzimskog Skrining Testa Za Novorodenu Decu U Odnosu Na Troskove Lecenja Pacijenata Sa Favizmom Hospitalizovanih Usled Hemolize], Medicinski Casopis (2020)
10. Zinc Status As Compared to Zinc Intake and Iron Status: A Case Study of Iranian Populations From Isfahan Province, International Journal for Vitamin and Nutrition Research (2013)
11. Application of the Precede Model for Controlling Iron-Deficiency Anemia Among Children Aged 1-5, Kerman, Iran., Promotion & education (2006)
12. Combined Therapy of Silymarin and Desferrioxamine in Patients With Β-Thalassemia Major: A Randomized Double-Blind Clinical Trial, Fundamental and Clinical Pharmacology (2009)
13. Dietary Determinants of Pregnancy Induced Hypertension in Isfahan, Journal of Research in Medical Sciences (2008)
14. A Systematic Review and Meta-Analysis on the Prevalence of Zinc Deficiency in Iranian Population, Journal of Pediatrics Review (2023)
15. The Relation Between Body Iron Store and Ferritin, and Coronary Artery Disease, ARYA Atherosclerosis (2014)
16. Protective Role of Silymarin and Deferoxamine Against Iron Dextran-Induced Renal Iron Deposition in Male Rats, International Journal of Preventive Medicine (2013)
17. T2-Weighted Cardiovascular Magnetic Resonance and Echocardiographic Arterial Elasticity Criteria for Monitoring Cardiac Siderosis in Patients With Beta-Thalassemia Major, Journal of Research in Medical Sciences (2022)
18. Comparison of Sun Exposure Versus Vitamin D Supplementation for Pregnant Women With Vitamin D Deficiency, Journal of Maternal-Fetal and Neonatal Medicine (2019)
19. The Association Between Serum Selenium and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis, Journal of Trace Elements in Medicine and Biology (2015)
20. Evaluating the Effect of Digital Game-Based Nutrition Education on Anemia Indicators in Adolescent Girls: A Randomized Clinical Trial, Food Science and Nutrition (2023)
21. Co-Administration of Silymarin and Deferoxamine Against Kidney, Liver and Heart Iron Deposition in Male Iron Overload Rat Model, International Journal of Preventive Medicine (2014)
22. A Randomized Double-Blind, Placebo-Controlled Study of Therapeutic Effects of Silymarin in Β-Thalassemia Major Patients Receiving Desferrioxamine, European Journal of Haematology (2013)
23. Effect of Consuming Zinc-Fortified Bread on Serum Zinc and Iron Status of Zinc-Deficient Women: A Double Blind, Randomized Clinical Trial, International Journal of Preventive Medicine (2012)
24. Effects of a Period of Selected Aerobic Exercise on the Levels of Hemoglobin, Hematocrit and Red Blood Cells in Pregnant Women, Koomesh (2011)
25. Dietary Patterns Among Pregnant Women in the West-North of Iran, Pakistan Journal of Biological Sciences (2008)
26. Magnesium Supplementation Affects Metabolic Status and Pregnancy Outcomes in Gestational Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial, American Journal of Clinical Nutrition (2015)
27. Iron Deficiency in Goitrous Schoolchildren of Semirom, Iran, Hormone Research (2006)
28. Effects of Vitamin D Supplementation on Glucose Metabolism, Lipid Concentrations, Inflammation, and Oxidative Stress in Gestational Diabetes: A Double-Blind Randomized Controlled Clinical Trial1-3, American Journal of Clinical Nutrition (2013)
29. Calcium-Vitamin D Co-Supplementation Affects Metabolic Profiles, But Not Pregnancy Outcomes, in Healthy Pregnant Women, International Journal of Preventive Medicine (2016)
30. Scrutiny Relationship Between Distributions of Hypothyroidism With Environmental Iron Deficiency in Isfahan Province, Iran, Journal of Isfahan Medical School (2011)
31. Effects of Radiofrequency Radiation on Human Ferritin: An in Vitro Enzymun Assay, Journal of Medical Signals and Sensors (2012)
32. Multivitamin Versus Multivitamin-Mineral Supplementation and Pregnancy Outcomes: A Single-Blind Randomized Clinical Trial, International Journal of Preventive Medicine (2014)
33. Prevalence of Microcytic Anemia Among Newborn Infants From Baharloo Hospital, Tehran, Iran, Tehran University Medical Journal (2021)
34. Changes in Bone Turnover, Inflammatory, Oxidative Stress, and Metabolic Markers in Women Consuming Iron Plus Vitamin D Supplements: A Randomized Clinical Trial, Biological Trace Element Research (2021)
35. The Effect of Combination Iron Chelating Agents on Reducing the Severity Grading of Heart and Liver Iron Overload in Β-Thalassemia Patients, Iranian Journal of Pediatric Hematology and Oncology (2019)
36. Effect of Prenatal Zinc Supplementation on Adipose Tissue-Derived Hormones and Neonatal Weight, Height and Head Circumference in Women With Impaired Glucose Tolerance Test: Randomized Clinical Controlled Trial, International Journal of Diabetes in Developing Countries (2019)
37. The Effect of Chromium on Parameters Related to Iron Metabolism, Biological Trace Element Research (1992)
38. Teff Consumption and Anemia in Pregnant Ethiopian Women: A Case–Control Study, European Journal of Nutrition (2019)
39. Effects of Selenium Supplementation on Glucose Homeostasis, Inflammation, and Oxidative Stress in Gestational Diabetes: Randomized, Double-Blind, Placebo-Controlled Trial, Nutrition (2015)
40. The Comparison of Efficacy of Original Brand Deferoxamine With Generic Iranian Made Deferoxamine in Urinary Iron Excretion in Patients With Thalassemia Major, Iranian Journal of Blood and Cancer (2018)
41. The Correlation Between the Cardiac and Hepatic Iron-Overload in Patients With Thalassemia Major Who Received Multiple Transfusion, Journal of Isfahan Medical School (2010)
42. Body Mass Index and Its Relationship With Hematological Indices in Iranian Women, Pakistan Journal of Nutrition (2008)
43. Determination of the Need for Prenatal Diagnosis in Carriers of Alpha Thalassemia, Journal of Isfahan Medical School (2013)
44. The Effect of Vitamin D Supplementation on Oxidative Stress and Inflammatory Biomarkers in Pregnant Women: A Systematic Review and Meta-Analysis of Clinical Trials, BMC Pregnancy and Childbirth (2022)
45. Association of Body Mass Index and Serum Ferritin Level in Pediatrics With Beta-Thalassemia Major Disease, Iranian Journal of Pediatric Hematology and Oncology (2022)
46. Effects of Zinc Supplementation During Pregnancy on Pregnancy Outcome in Women With History of Preterm Delivery: A Double-Blind Randomized, Placebo-Controlled Trial, Journal of Maternal-Fetal and Neonatal Medicine (2010)
47. Effects of Iron on Vitamin D Metabolism: A Systematic Review, International Journal of Preventive Medicine (2016)
48. Valuation of Vitamin D Level at the End of First Trimester and Its Relation With Anemia, Bacterial Vaginosis, and Toothache in Pregnant Mothers, Journal of Isfahan Medical School (2015)
49. Effect of Daily Consumption of Probiotic Yoghurt on Serum Levels of Calcium, Iron and Liver Enzymes in Pregnant Women, International Journal of Preventive Medicine (2013)
50. Association Between Serum Ferritin and Goitre in Iranian School Children, Journal of Health, Population and Nutrition (2010)