Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effects of Nanozeolite/Starch Thermoplastic Hydrogels on Wound Healing Publisher



Salehi H1 ; Mehrasa M2 ; Nasrinasrabadi B3 ; Doostmohammadi M3 ; Seyedebrahimi R1 ; Davari N4 ; Rafenia M5 ; Ebrahimianhosseinabadi M6 ; Agheb M7 ; Siavash M8
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Biotechnology, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan, Iran
  3. 3. Department of Chemical Engineering, Isfahan University of Technology, Isfahan, Iran
  4. 4. Department of Medical Sciences, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
  5. 5. Biosensor Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran
  7. 7. Research Centre of Faculty of Advanced Technologies, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Research in Medical Sciences Published:2017


Abstract

Background: Wound healing is a complex biological process. Some injuries lead to chronic nonhealing ulcers, and healing process is a challenge to both the patient and the medical team. We still look forward an appropriate wound dressing. Materials and Methods: In this study, starch-based nanocomposite hydrogel scaffolds reinforced by zeolite nanoparticles (nZ) were prepared for wound dressing. In addition, a herbal drug (chamomile extract) was added into the matrix to accelerate healing process. To estimate the cytocompatibility of hydrogel dressings, fibroblast mouse cells (L929) were cultured on scaffolds. Then, 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium-bromide assay test and interaction of cells and scaffolds were evaluated. For evaluating healing process, 48 male rats were randomly divided into four groups of four animals each (16 rats at each step). The ulcers of the first group were treated with the same size of pure hydrogels. The second group received a bandage with the same size of hydrogel/extract/4 wt% nZ (hydrogel NZE). The third group was treated with chamomile extract, and the fourth group was considered as control without taking any medicament. Finally, the dressings were applied on the chronic refractory ulcers of five patients. Results: After successful surface morphology and cytocompatibility tests, the animal study was carried out. There was a significant difference between starch/extract/4 wt% nZ and other groups on wound size decrement after day 7 (P < 0.05). At the clinical pilot study step, the refractory ulcers of all five patients were healed without any hypersensitivity reaction. Conclusion: Starch-based hydrogel/zeolite dressings may be safe and effective for chronic refractory ulcers. © 2017 Journal of Research in Medical Sciences.
Related Docs
View other Related Docs
1. Pmma Nanofibers Containing Keplerate-Type Polyoxometalate and Metronidazole: Preparation and Wound-Healing Effect in a Rat Model, Journal of Drug Delivery Science and Technology (2022)
2. Fabrication and Characterisation of Chitosan/Polyvinyl Alcohol-Based Transparent Hydrogel Films Loaded With Silver Nanoparticles and Sildenafil Citrate for Wound Dressing Applications, Materials Technology (2022)
3. Acceleration of Wound Healing in Rats by Modified Lignocellulose Based Sponge Containing Pentoxifylline Loaded Lecithin/Chitosan Nanoparticles, Gels (2022)
4. The Effects of Polyvinyl Pyrrolidone Hydrogel Dressing on Open-Wound Healing in Rats, Journal of Isfahan Medical School (2015)
5. A Novel Bilayer Wound Dressing Composed of a Dense Polyurethane/Propolis Membrane and a Biodegradable Polycaprolactone/Gelatin Nanofibrous Scaffold, Scientific Reports (2020)
6. Deep Skin Wound Healing Potential of Lavender Essential Oil and Licorice Extract in a Nanoemulsion Form: Biochemical, Histopathological and Gene Expression Evidences, Journal of Tissue Viability (2020)
7. Cornstarch-Based Wound Dressing Incorporated With Hyaluronic Acid and Propolis: In Vitro and in Vivo Studies, Carbohydrate Polymers (2019)
8. Cerium Oxide Nanoparticles: Synthesis Methods and Applications in Wound Healing, Materials Today Bio (2023)
Experts (# of related papers)
View all Related Experts
Jaleh Varshosaz (29)
Mohammad Rafienia (21)
Other Related Docs
9. Fabrication and Characterization of Glycerol/Chitosan/Polyvinyl Alcohol-Based Transparent Hydrogel Films Loaded With Silver Nanoparticles for Antibacterial Wound Dressing Applications, Advanced Biomedical Research (2021)
10. Comparing the Wound Healing Effect of a Controlled Release Wound Dressing Containing Curcumin/Ciprofloxacin and Simvastatin/Ciprofloxacin in a Rat Model: A Preclinical Study, Journal of Biomedical Materials Research - Part A (2022)
11. Sa/G Hydrogel Containing Nrf2-Engineered Hek-293-Derived Cm Improves Wound Healing Efficacy of Wj-Mscs in a Rat Model of Excision Injury, Journal of Tissue Viability (2021)
12. Novel Electrospun Polyvinyl Alcohol/Chitosan/Polycaprolactone-Diltiazem Hydrochloride Nanocomposite Membranes for Wound Dressing Applications, Emergent Materials (2024)
13. Preparation and Characterization of an Antibacterial Cmc/Pcl Hydrogel Films Containing Cip/Cur: In Vitro and in Vivo Evaluation of Wound Healing Activity, International Journal of Biological Macromolecules (2024)
14. An Injectable Carboxymethyl Chitosan-Methylcellulose-Pluronic Hydrogel for the Encapsulation of Meloxicam Loaded Nanoparticles, International Journal of Biological Macromolecules (2020)
15. Evaluation of Wound Healing and Antimicrobial Properties of Hydrogel Dressings of Starch Containing Ethanolic Extract of Propolis in the Rat, Journal of Isfahan Medical School (2018)
16. An in Vitro and in Vivo Study of Electrospun Polyvinyl Alcohol/Chitosan/Sildenafil Citrate Mat on 3D-Printed Polycaprolactone Membrane As a Double Layer Wound Dressing, International Journal of Biological Macromolecules (2024)
17. Characterization of Silk/Poly 3-Hydroxybutyrate-Chitosan-Multi-Walled Carbon Nanotube Micro-Nano Scaffold: A New Hybrid Scaffold for Tissue Engineering Applications, Journal of Medical Signals and Sensors (2018)
18. Preparation and in Vivo Evaluation of a Novel Gel-Based Wound Dressing Using Arginine–Alginate Surface-Modified Chitosan Nanofibers, Journal of Biomaterials Applications (2018)
19. Wound Healing Activity of Pimpinella Anisum Methanolic Extract in Streptozotocin-Induced Diabetic Rats, Journal of Wound Care (2019)
20. In Vivo Study of Non-Invasive Effects of Non-Thermal Plasma in Pressure Ulcer Treatment, Scientific Reports (2018)
21. Remedial Effect of Boswellia Serrata on Thermal Burn Injuries, Shiraz E Medical Journal (2015)
22. Nanobiomaterials in Periodontal Tissue Engineering, Nanobiomaterials in Hard Tissue Engineering: Applications of Nanobiomaterials (2016)
23. A Promising Antibacterial Wound Dressing Made of Electrospun Poly (Glycerol Sebacate) (Pgs)/Gelatin With Local Delivery of Ascorbic Acid and Pantothenic Acid, Journal of Polymers and the Environment (2023)
24. Fabrication and Evaluation of Cs/Pvp Sponge Containing Platelet-Rich Fibrin As a Wound Healing Accelerator: An in Vitro and in Vivo Study, International Journal of Biological Macromolecules (2022)
25. Nanocrystalline Cellulose-Hyaluronic Acid Composite Enriched With Gm-Csf Loaded Chitosan Nanoparticles for Enhanced Wound Healing, Biomedical Materials (Bristol) (2019)
26. Intravenous Administration of Granulocyte-Colony Stimulating Factor for Stem Cells Mobilization and Third Degree Burn Wound Healing in Rats, Journal of Applied Biotechnology Reports (2019)
27. Sodium Alginate/Magnesium Oxide Nanocomposite Scaffolds for Bone Tissue Engineering, Polymers for Advanced Technologies (2018)
28. Incorporating Fingolimod Through Poly(Lactic-Co-Glycolic Acid) Nanoparticles in Electrospun Polyurethane/Polycaprolactone/Gelatin Scaffold: An in Vitro Study for Nerve Tissue Engineering, Polymers for Advanced Technologies (2022)
29. Alleviating Neuropathy of Diabetic Foot Ulcer by Co-Delivery of Venlafaxine and Matrix Metalloproteinase Drug-Loaded Cellulose Nanofiber Sheets: Production, in Vitro Characterization and Clinical Trial, Pharmacological Reports (2021)
30. Incorporation of Nanohydroxyapatite and Vitamin D3 Into Electrospun Pcl/Gelatin Scaffolds: The Influence on the Physical and Chemical Properties and Cell Behavior for Bone Tissue Engineering, Polymers for Advanced Technologies (2018)
31. Preparation and Characterization of Poly Ε-Caprolactone-Gelatin/Multi-Walled Carbon Nanotubes Electrospun Scaffolds for Cartilage Tissue Engineering Applications, International Journal of Polymeric Materials and Polymeric Biomaterials (2020)
32. Combination Therapy of Metadichol Nanogel and Lipocalin-2 Engineered Mesenchymal Stem Cells Improve Wound Healing in Rat Model of Excision Injury, Advanced Pharmaceutical Bulletin (2022)
33. Insight Into the Current Directions in Functionalized Nanocomposite Hydrogels, Frontiers in Materials (2020)
34. Fabrication and Evaluation of 3D Bio-Scaffold Wound Dressings for Monitoring of Chronic Ph Wounds Using Fuzzy Logic Analysis, Materials Science and Engineering: B (2023)
35. Cytocompatibility and Antibacterial Properties of Coaxial Electrospun Nanofibers Containing Ciprofloxacin and Indomethacin Drugs, Polymers (2022)
36. Comparison of the Silver Nanocrystalline Dressing and Paraffin Gauze on the Outcomes of Split-Thickness Skin Graft Donor Site; [مقايسهی پیامدهای متعاقب پانسمان سیلیکونی حاوی نانوک ريستالی نقره با پوشش گاز وازلین بر رو ی زخم محل (Donor Graft) دهندهی پیوند پوست], Journal of Isfahan Medical School (2024)
37. Polycaprolactone/Gelatin/Hydroxyapatite Nanocomposite Scaffold Seeded With Stem Cells From Human Exfoliated Deciduous Teeth to Enhance Bone Repair: In Vitro and in Vivo Studies, Materials Technology (2022)
38. The Effect of Dressing With Fresh Kiwifruit on Burn Wound Healing, Surgery (2010)
39. Improved Wound Healing of Diabetic Foot Ulcers Using Human Placenta-Derived Mesenchymal Stem Cells in Gelatin Electrospun Nanofibrous Scaffolds Plus a Platelet-Rich Plasma Gel: A Randomized Clinical Trial, International Immunopharmacology (2021)
40. Wound Healing by Topical Application of Antioxidant Iron Chelators: Kojic Acid and Deferiprone, International Wound Journal (2013)
41. Local Delivery of Usnic Acid Loaded Rhamnolipid Vesicles by Gelatin / Tragacanth Gum / Montmorillonite/ Vanillin Cryogel Scaffold for Expression of Osteogenic Biomarkers and Antimicrobial Activity, Journal of Drug Delivery Science and Technology (2022)
42. Keratin- and Vegf-Incorporated Honey-Based Sponge-Nanofiber Dressing: An Ideal Construct for Wound Healing, ACS Applied Materials and Interfaces (2023)
43. Enhancing the Wound Healing Process Through Local Injection of Exosomes Derived From Blood Serum: An in Vitro and in Vivo Assessment, Regenerative Therapy (2024)
44. Evaluation of the Effects of Zein Incorporation on Physical, Mechanical, and Biological Properties of Polyhydroxybutyrate Electrospun Scaffold for Bone Tissue Engineering Applications, International Journal of Biological Macromolecules (2023)
45. An Injectable Thermosensitive Hydrogel/Nanomicelles Composite for Local Chemo-Immunotherapy in Mouse Model of Melanoma, Journal of Biomaterials Applications (2022)
46. Physical and Biological Properties of Blend-Electrospun Polycaprolactone/Chitosan-Based Wound Dressings Loaded With N-Decyl-N, N-Dimethyl-1-Decanaminium Chloride: An in Vitro and in Vivo Study, Journal of Biomedical Materials Research - Part B Applied Biomaterials (2020)
47. Platelet Rich Fibrin Containing Nanofibrous Dressing for Wound Healing Application: Fabrication, Characterization and Biological Evaluations, Materials Science and Engineering C (2021)
48. The Effect of Estrogen on Wound Healing in Rats, Pakistan Journal of Medical Sciences (2007)
49. A Novel Wound Dressing Nanofiber With Anti-Inflammatory and Anti-Bacterial Drugs Release for Skin Wound Healing, Journal of Isfahan Medical School (2019)
50. Preparation and in Vitro Evaluation of Vancomycin Loaded Montmorillonite-Sodium Alginate Topical Gel for Wound Infection, Brazilian Journal of Pharmaceutical Sciences (2022)