Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Effects of Polyvinyl Pyrrolidone Hydrogel Dressing on Open-Wound Healing in Rats



Varzaneh RF1 ; Moshtaghian SJ1 ; Talebi A2 ; Abedini F3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Biology, School of Sciences, University of Isfahan, Isfahan, Iran
  2. 2. Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Burn Causalities Hospital of Isfahan, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2015

Abstract

Background: Different compounds and methods have been used for wound healing over years. New dressings such as hydrogels have shown remarkable effects on wound healing. Hydrogels have been considered as favorite wound dressings due to their transparency, exchange of respiratory gases, adsorption of water and exudates, regulation of wound temperature, prevention of infections and easy replacement. This study was designed to investigate the effects of polyvinylpyrrolidone hydrogel (PVP) dressing on wound healing in rats. Methods: 30 male Wistar rats weighing 230 ± 20 g were equally and semi-randomly distributed into 3 groups of control, treated with tetracycline and treated with hydrogel. After anesthesia and shaving the area, a 1 x 1 cm section was made on the skin of the back of the rats. The treatment period was 21 days and measurement of the wound area was performed on the days 0, 7, 10, 14, 17 and 21. Wound tissue samples for histopathologic examination were taken on the days 7 and 14. Data were analyzed via SPSS software using ANOVA test. Findings: Wound recovery in hydrogel group was significantly faster than other groups (P < 0.05). Duration of the wound presence and skin discoloration was also significantly shorter in hydrogel group (P < 0.05). Conclusion: The results of this study indicate that the hydrogel dressing leads to quick recovery of cutaneous wound. © 2015, Journal of Isfahan Medical School. All rights reserved.
Related Docs
View other Related Docs
1. Effects of Nanozeolite/Starch Thermoplastic Hydrogels on Wound Healing, Journal of Research in Medical Sciences (2017)
2. Fabrication and Characterization of Glycerol/Chitosan/Polyvinyl Alcohol-Based Transparent Hydrogel Films Loaded With Silver Nanoparticles for Antibacterial Wound Dressing Applications, Advanced Biomedical Research (2021)
3. Fabrication and Characterisation of Chitosan/Polyvinyl Alcohol-Based Transparent Hydrogel Films Loaded With Silver Nanoparticles and Sildenafil Citrate for Wound Dressing Applications, Materials Technology (2022)
4. Wound Healing Activity of Pimpinella Anisum Methanolic Extract in Streptozotocin-Induced Diabetic Rats, Journal of Wound Care (2019)
5. Acceleration of Wound Healing in Rats by Modified Lignocellulose Based Sponge Containing Pentoxifylline Loaded Lecithin/Chitosan Nanoparticles, Gels (2022)
6. Histologic Evaluation of the Effects of Folinic Acid Chitosan Hydrogel and Botulinum Toxin a on Wound Repair of Cleft Lip Surgery in Rats, Journal of Functional Biomaterials (2022)
7. A Bifunctional Electrospun Nanocomposite Wound Dressing Containing Surfactin and Curcumin: In Vitro and in Vivo Studies, Materials Science and Engineering C (2021)
8. The Efficacy of Oral Hydrogel Containing Hyaluronic Acid, Polyvinylpyrrolidone, and Glycyrrhizin for Prevention and Treatment of Oral Mucositis Induced by Chemotherapy, Journal of Isfahan Medical School (2021)
Experts (# of related papers)
View all Related Experts
Mohammad Rafienia (13)
Jaleh Varshosaz (12)
Other Related Docs
9. Deep Skin Wound Healing Potential of Lavender Essential Oil and Licorice Extract in a Nanoemulsion Form: Biochemical, Histopathological and Gene Expression Evidences, Journal of Tissue Viability (2020)
10. Antibacterial Self-Healing Bilayer Dressing for Epidermal Sensors and Accelerate Wound Repair, Carbohydrate Polymers (2023)
11. Comparing the Wound Healing Effect of a Controlled Release Wound Dressing Containing Curcumin/Ciprofloxacin and Simvastatin/Ciprofloxacin in a Rat Model: A Preclinical Study, Journal of Biomedical Materials Research - Part A (2022)
12. Preparation and Characterization of an Antibacterial Cmc/Pcl Hydrogel Films Containing Cip/Cur: In Vitro and in Vivo Evaluation of Wound Healing Activity, International Journal of Biological Macromolecules (2024)
13. A Promising Antibacterial Wound Dressing Made of Electrospun Poly (Glycerol Sebacate) (Pgs)/Gelatin With Local Delivery of Ascorbic Acid and Pantothenic Acid, Journal of Polymers and the Environment (2023)
14. A Novel Bilayer Wound Dressing Composed of a Dense Polyurethane/Propolis Membrane and a Biodegradable Polycaprolactone/Gelatin Nanofibrous Scaffold, Scientific Reports (2020)
15. An in Vitro and in Vivo Study of Electrospun Polyvinyl Alcohol/Chitosan/Sildenafil Citrate Mat on 3D-Printed Polycaprolactone Membrane As a Double Layer Wound Dressing, International Journal of Biological Macromolecules (2024)
16. Wound Healing Effects of Quercus Brantii and Pelargonium Graveolens Extracts in Male Wistar Rats, Wounds (2016)
17. In Vivo Study of Non-Invasive Effects of Non-Thermal Plasma in Pressure Ulcer Treatment, Scientific Reports (2018)
18. Remedial Effect of Boswellia Serrata on Thermal Burn Injuries, Shiraz E Medical Journal (2015)
19. Pmma Nanofibers Containing Keplerate-Type Polyoxometalate and Metronidazole: Preparation and Wound-Healing Effect in a Rat Model, Journal of Drug Delivery Science and Technology (2022)
20. Effect of Green Tea (Camellia Sinensis) Extract on Healing Process of Surgical Wounds in Rat, International Journal of Surgery (2013)
21. Fabrication and Evaluation of Cs/Pvp Sponge Containing Platelet-Rich Fibrin As a Wound Healing Accelerator: An in Vitro and in Vivo Study, International Journal of Biological Macromolecules (2022)
22. Evaluation of Wound Healing and Antimicrobial Properties of Hydrogel Dressings of Starch Containing Ethanolic Extract of Propolis in the Rat, Journal of Isfahan Medical School (2018)
23. An Injectable Carboxymethyl Chitosan-Methylcellulose-Pluronic Hydrogel for the Encapsulation of Meloxicam Loaded Nanoparticles, International Journal of Biological Macromolecules (2020)
24. Fabrication and Evaluation of 3D Bio-Scaffold Wound Dressings for Monitoring of Chronic Ph Wounds Using Fuzzy Logic Analysis, Materials Science and Engineering: B (2023)
25. Novel Electrospun Polyvinyl Alcohol/Chitosan/Polycaprolactone-Diltiazem Hydrochloride Nanocomposite Membranes for Wound Dressing Applications, Emergent Materials (2024)
26. The Effect of Dressing With Fresh Kiwifruit on Burn Wound Healing, Surgery (2010)
27. Sa/G Hydrogel Containing Nrf2-Engineered Hek-293-Derived Cm Improves Wound Healing Efficacy of Wj-Mscs in a Rat Model of Excision Injury, Journal of Tissue Viability (2021)
28. Wound Healing by Topical Application of Antioxidant Iron Chelators: Kojic Acid and Deferiprone, International Wound Journal (2013)
29. Shear Sensitive Injectable Hydrogels of Cross-Linked Tragacanthic Acid for Ocular Drug Delivery: Rheological and Biological Evaluation, International Journal of Biological Macromolecules (2020)
30. Physical and Biological Properties of Blend-Electrospun Polycaprolactone/Chitosan-Based Wound Dressings Loaded With N-Decyl-N, N-Dimethyl-1-Decanaminium Chloride: An in Vitro and in Vivo Study, Journal of Biomedical Materials Research - Part B Applied Biomaterials (2020)
31. The Effect of Estrogen on Wound Healing in Rats, Pakistan Journal of Medical Sciences (2007)
32. A Novel Wound Dressing Nanofiber With Anti-Inflammatory and Anti-Bacterial Drugs Release for Skin Wound Healing, Journal of Isfahan Medical School (2019)
33. Preparation and in Vitro Evaluation of Vancomycin Loaded Montmorillonite-Sodium Alginate Topical Gel for Wound Infection, Brazilian Journal of Pharmaceutical Sciences (2022)
34. In Vitro and in Vivo Performance of a Propolis-Coated Polyurethane Wound Dressing With High Porosity and Antibacterial Efficacy, Colloids and Surfaces B: Biointerfaces (2019)
35. Development of Bioadhesive Chitosan Gels for Topical Delivery of Lidocaine, Scientia Pharmaceutica (2006)
36. Multilayer Pva/Gelatin Nanofibrous Scaffolds Incorporated With Tanacetum Polycephalum Essential Oil and Amoxicillin for Skin Tissue Engineering Application, International Journal of Biological Macromolecules (2024)
37. The Effect of Vitamin a and Vitamin C on Postoperative Adhesion Formation: A Rat Model Study, Journal of Research in Medical Sciences (2014)
38. Rgd Peptide Grafted Polybutylene Adipate-Co-Terephthalate/Gelatin Electrospun Nanofibers Loaded With a Matrix Metalloproteinase Inhibitor Drug for Alleviating of Wounds: An In Vitro/In Vivo Study, Drug Development and Industrial Pharmacy (2020)
39. Coaxial Electrospun Pgs/Pcl and Pgs/Pgs-Pcl Nanofibrous Membrane Containing Platelet-Rich Plasma for Skin Tissue Engineering, Journal of Biomaterials Science, Polymer Edition (2024)
40. Pdgf and Vegf-Releasing Bi-Layer Wound Dressing Made of Sodium Tripolyphosphate Crosslinked Gelatin-Sponge Layer and a Carrageenan Nanofiber Layer, International Journal of Biological Macromolecules (2023)
41. The Beneficial Property of Hydroalcoholic Extract of Annab on Burn Healing, Life Science Journal (2012)
42. Preparation and Evaluation of Poly Glycerol Sebacate/Poly Hydroxy Butyrate Core-Shell Electrospun Nanofibers With Sequentially Release of Ciprofloxacin and Simvastatin in Wound Dressings, Polymers for Advanced Technologies (2018)
43. Injectable Natural Polymer Compound for Tissue Engineering of Intervertebral Disc: In Vitro Study, Materials Science and Engineering C (2017)
44. Alginate Hydrogel Enriched With Ambystoma Mexicanum Epidermal Lipoxygenase-Loaded Pectin Nanoparticles for Enhanced Wound Healing, Journal of Biomaterials Applications (2020)
45. Cornstarch-Based Wound Dressing Incorporated With Hyaluronic Acid and Propolis: In Vitro and in Vivo Studies, Carbohydrate Polymers (2019)
46. Multifunctional Electrospun Polyvinyl Alcohol/Gellan Gum/Polycaprolactone Nanofibrous Membrane Containing Pentoxifylline to Accelerate Wound Healing, Polymer Bulletin (2023)
47. A Propolis Enriched Polyurethane-Hyaluronic Acid Nanofibrous Wound Dressing With Remarkable Antibacterial and Wound Healing Activities, International Journal of Biological Macromolecules (2020)
48. Surface Modification of Poly (Ethylene Terephthalate) Fabric by Soy Protein Isolate Hydrogel for Wound Dressing Application, International Journal of Polymeric Materials and Polymeric Biomaterials (2019)
49. A Double-Layer Cellulose/Pectin-Soy Protein Isolate-Pomegranate Peel Extract Micro/Nanofiber Dressing for Acceleration of Wound Healing, International Journal of Biological Macromolecules (2024)
50. A Multifunctional Nanocomposite Spray Dressing of Kappa-Carrageenan-Polydopamine Modified Zno/L-Glutamic Acid for Diabetic Wounds, Materials Science and Engineering C (2020)