Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Mechanochemical Synthesis Evaluation of Nanocrystalline Bone-Derived Bioceramic Powder Using for Bone Tissue Engineering Publisher



Khandan A1 ; Karamian E2 ; Bonakdarchian M3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Mechanical Engineering, Khomeinishahr Branch, Islamic Azad University, Khomeinishahr/Isfahan, Iran
  2. 2. Department of Materials Engineering, Najafabad Branch, Islamic Azad University, Isfahan, Iran
  3. 3. Department of Prosthodontics, Torabinejad Dental Research Center, School of Dentistry, Isfahan, Iran

Source: Dental Hypotheses Published:2014


Abstract

Introduction: Bone tissue engineering proposes a suitable way to regenerate lost bones. Different materials have been considered for use in bone tissue engineering. Hydroxyapatite (HA) is a significant success of bioceramics as a bone tissue repairing biomaterial. Among different bioceramic materials, recent interest has been risen on fluorinated hydroxyapatites, (FHA, Ca10(PO4)6Fx(OH)2-x). Fluorine ions can promote apatite formation and improve the stability of HA in the biological environments. Therefore, they have been developed for bone tissue engineering. The aim of this study was to synthesize and characterize the FHA nanopowder via mechanochemical (MC) methods. Materials and Methods: Natural hydroxyapatite (NHA) 95.7 wt.% and calcium fluoride (CaF2) powder 4.3 wt.% were used for synthesis of FHA. MC reaction was performed in the planetary milling balls using a porcelain cup and alumina balls. Ratio of balls to reactant materials was 15:1 at 400 rpm rotation speed. The structures of the powdered particles formed at different milling times were evaluated by X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Results: Fabrication of FHA from natural sources like bovine bone achieved after 8 h ball milling with pure nanopowder. Conclusion: F-ion enhances the crystallization and mechanical properties of HA in formation of bone. The produced FHA was in nano-scale, and its crystal size was about 80-90 nm with sphere distribution in shape and size. FHA powder is a suitable biomaterial for bone tissue engineering.
Related Docs
View other Related Docs
1. Biodegradation Assessment of Nanostructured Fluoridated Hydroxyapatite Coatings on Biomedical Grade Magnesium Alloy, Ceramics International (2014)
2. Effect of Different Sol-Gel Synthesis Processes on Microstructural and Morphological Characteristics of Hydroxyapatite-Bioactive Glass Composite Nanopowders, Journal of Advanced Ceramics (2014)
3. Preparation and Bioactivity Evaluation of Bone-Like Hydroxyapatite Nanopowder, Journal of Materials Processing Technology (2008)
4. Surface Modification of Mg-Doped Fluoridated Hydroxyapatite Nanoparticles Using Bioactive Amino Acids As the Coupling Agent for Biomedical Applications, Ceramics International (2015)
5. The Electrospun Poly(Ε-Caprolactone)/Fluoridated Hydroxyapatite Nanocomposite for Bone Tissue Engineering, Polymers for Advanced Technologies (2020)
6. Combinatorial Fluorapatite-Based Scaffolds Substituted With Strontium, Magnesium and Silicon Ions for Mending Bone Defects, Materials Science and Engineering C (2021)
7. Synthesis and Characterization of Nanosized Magnesium-Doped Fluorapatite Powder and Coating for Biomedical Application, Journal of Sol-Gel Science and Technology (2015)
8. Structural Comparison of Natural and Synthetic Nanocrystalline Hydroxyapatite, Journal of Isfahan Medical School (2012)
Experts (# of related papers)
View all Related Experts
Saeed Karbasi (31)
Mohammad Rafienia (22)
Other Related Docs
9. Synthesis and Dissolution Behavior of Nanosized Silicon and Magnesium Co-Doped Fluorapatite Obtained by High Energy Ball Milling, Ceramics International (2014)
10. Synthesis, Characterization and Bioactivity Evaluation of Nano-Structured Hydroxyapatite, WIT Transactions on Engineering Sciences (2009)
11. Synthesis, Characterization, in Vitro Bioactivity and Biocompatibility Evaluation of Hydroxyapatite/Bredigite (Ca7mgsi4o16) Composite Nanoparticles, JOM (2016)
12. Synthesis and Characterization of Fluorapatite Nanoparticles Via a Mechanochemical Method, Journal of Cluster Science (2015)
13. Preparation and Biocompatibility Evaluation of Bioactive Glass-Forsterite Nanocomposite Powder for Oral Bone Defects Treatment Applications, Materials Science and Engineering C (2015)
14. Ultra-Fast, Highly Efficient and Green Synthesis of Bioactive Forsterite Nanopowder Via Microwave Irradiation, Materials Science and Engineering C (2018)
15. Effects of Adding Forsterite Bioceramic on in Vitro Activity and Antibacterial Properties of Bioactive Glass-Forsterite Nanocomposite Powders, Advanced Powder Technology (2016)
16. Biodegradable Magnesium Alloy Coated by Fluoridated Hydroxyapatite Using Mao/Epd Technique, Surface Engineering (2014)
17. Fabrication and Characterization of 3D-Printed Composite Scaffolds of Coral-Derived Hydroxyapatite Nanoparticles/Polycaprolactone/Gelatin Carrying Doxorubicin for Bone Tissue Engineering, Journal of Materials Science: Materials in Medicine (2024)
18. Modified Mechanical Coating Technique for the Preparation of Nanohydroxyapatite Coated Ti–6Al–4V Dental Implants, Protection of Metals and Physical Chemistry of Surfaces (2020)
19. In Vitro Analysis of Electrophoretic Deposited Fluoridated Hydroxyapatite Coating on Micro-Arc Oxidized Az91 Magnesium Alloy for Biomaterials Applications, Metallurgical and Materials Transactions A: Physical Metallurgy and Materials Science (2015)
20. Development of Porous Photopolymer Resin-Swcnt Produced by Digital Light Processing Technology Using for Bone Femur Application, Archives of Bone and Joint Surgery (2021)
21. Evaluation of Physical, Mechanical and Biological Properties of Β-Tri-Calcium Phosphate/Poly-3-Hydroxybutyrate Nano Composite Scaffold for Bone Tissue Engineering Application, Materials Technology (2021)
22. Morphology and Degradation of Poly (3-Hydroxybutyrate)/ Nano-Hydroxyapatite Scaffold Used in Tissue Engineering, Journal of Isfahan Medical School (2012)
23. Mechanical Evaluation of Nhap Scaffold Coated With Poly-3-Hydroxybutyrate for Bone Tissue Engineering, Journal of Nanoscience and Nanotechnology (2013)
24. On the Bioactivity and Mechanical Properties of Gehlenite Nanobioceramic: A Comparative Study, Journal of Medical Signals and Sensors (2020)
25. Simultaneous Structural and Surface Modifications of Nanophase Hydroxyapatite for Improving Its Dissolution and Bioactivity, Ceramics International (2016)
26. Natural Hydroxyapatite/Diopside Nanocomposite Scaffold for Bone Tissue Engineering Applications: Physical, Mechanical, Bioactivity and Biodegradation Evaluation, Materials Technology (2022)
27. Effect of Mg Content on the Bioactivity and Biocompatibility of Mg-Substituted Fluorapatite Nanopowders Fabricated Via Mechanical Activation, Materials Science and Engineering C (2016)
28. Comparative Evaluation of Hydroxyapatite and Nano-Bioglass in Two Forms of Conventional Micro-And Nano-Particles in Repairing Bone Defects (An Animal Study), Indian Journal of Dental Research (2015)
29. Physical and Mechanical Properties of a Poly-3-Hydroxybutyratecoated Nanocrystalline Hydroxyapatite Scaffold for Bone Tissue Engineering, Journal of Porous Materials (2012)
30. Gehlenite Nanobioceramic: Sol-Gel Synthesis, Characterization, and in Vitro Assessment of Its Bioactivity, Materials Letters (2018)
31. In Vitro Study of a Novel Multi-Substituted Hydroxyapatite Nanopowder Synthesized by an Ultra-Fast, Efficient and Green Microwave-Assisted Method, Materials Science and Engineering C (2020)
32. Preparation, Chemistry and Physical Properties of Bone-Derived Hydroxyapatite Particles Having a Negative Zeta Potential, Materials Chemistry and Physics (2012)
33. Evaluation of Physical and Mechanical Properties of Fi-Tri-Calcium Phosphate/Poly-3-Hydroxybutyrate Nanocomposite Scaffold for Bone Tissue Engineering Application, Scientia Iranica (2017)
34. Biodegradable Nanocomposite Coatings Accelerate Bone Healing: In Vivo Evaluation, Dental Research Journal (2015)
35. A Novel Flexible, Conductive, and Three-Dimensional Reduced Graphene Oxide/Polyurethane Scaffold for Cell Attachment and Bone Regeneration, Materials and Design (2022)
36. Fabrication of Elastin Additive on Polymethyl Methacrylate and Hydroxyapatite-Based Bioactive Bone Cement, Materials Chemistry and Physics (2022)
37. In Vitro Characterisation of a Sol–Gel Derived in Situ Silica-Coated Silicate and Carbonate Co-Doped Hydroxyapatite Nanopowder for Bone Grafting, Materials Science and Engineering C (2017)
38. Polycaprolactone/Gelatin/Hydroxyapatite Nanocomposite Scaffold Seeded With Stem Cells From Human Exfoliated Deciduous Teeth to Enhance Bone Repair: In Vitro and in Vivo Studies, Materials Technology (2022)
39. Preparation of a Novel Biodegradable Nanocomposite Scaffold Based on Poly (3-Hydroxybutyrate)/Bioglass Nanoparticles for Bone Tissue Engineering, Journal of Materials Science: Materials in Medicine (2010)
40. Investigation of the Mechanical Properties of a Bony Scaffold for Comminuted Distal Radial Fractures: Addition of Akermanite Nanoparticles and Using a Freeze-Drying Technique, Journal of the Mechanical Behavior of Biomedical Materials (2021)
41. The Characteristics of Human Osteoblast Cells in Two Methods of Monolayer Culture in Hydroxyapatite-Tricalcium Phosphate Scafolds, Journal of Isfahan Medical School (2011)
42. Local Delivery of Usnic Acid Loaded Rhamnolipid Vesicles by Gelatin / Tragacanth Gum / Montmorillonite/ Vanillin Cryogel Scaffold for Expression of Osteogenic Biomarkers and Antimicrobial Activity, Journal of Drug Delivery Science and Technology (2022)
43. Novel Electrophoretic Deposited Nanostructured Forsterite Coating on 316L Stainless Steel Implants for Biocompatibility Improvement, Materials Letters (2015)
44. Effect of Calcium Silicate Nanoparticle on Surface Feature of Calcium Phosphates Hybrid Bio-Nanocomposite Using for Bone Substitute Application, Powder Technology (2020)
45. In Vivo Assessments of Bioabsorbable Az91 Magnesium Implants Coated With Nanostructured Fluoridated Hydroxyapatite by Mao/Epd Technique for Biomedical Applications, Materials Science and Engineering C (2015)
46. In Vivo and in Vitro Evaluation of Poly (Lactide-Co-Glycolide)/Bioactive Glass Nanocomposite Coating, Advanced Materials Research (2014)
47. Development of Electrospun Poly (Vinyl Alcohol)-Based Bionanocomposite Scaffolds for Bone Tissue Engineering, Journal of Biomedical Materials Research - Part A (2018)
48. Calcitonin-Loaded Octamaleimic Acid–Silsesquioxane Nanoparticles in Hydrogel Scaffold Support Osteoinductivity in Bone Regeneration, Pharmaceutical Development and Technology (2021)
49. Fabrication and Characterization of Polycaprolactone Fumarate/Gelatin-Based Nanocomposite Incorporated With Silicon and Magnesium Co-Doped Fluorapatite Nanoparticles Using Electrospinning Method, Materials Science and Engineering C (2020)
50. In Vitro Studies of Polycaprolactone Nanofibrous Scaffolds Containing Novel Gehlenite Nanoparticles, Journal of Medical Signals and Sensors (2021)