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Combinatorial Fluorapatite-Based Scaffolds Substituted With Strontium, Magnesium and Silicon Ions for Mending Bone Defects Publisher Pubmed



Golafshan N1, 2 ; Alehosseini M1, 3 ; Ahmadi T4 ; Talebi A5 ; Fathi M1 ; Kharaziha M1 ; Orive G6, 7, 8, 9 ; Castilho M2, 10 ; Dolatshahipirouz A3, 11
Authors
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Authors Affiliations
  1. 1. Department of Materials Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran
  2. 2. Department of Orthopaedics, University Medical Center Utrecht, GA Utrecht, Netherlands
  3. 3. Technical University of Denmark, DTU Health Tech, Center for Intestinal Absorption and Transport of Biopharmaceuticals, Kgs, 2800, Denmark
  4. 4. Department of Materials Engineering, Shahreza Branch, Islamic Azad University, Shahreza, Iran
  5. 5. Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country UPV/EHU, Paseo de la Universidad 7, Vitoria-Gasteiz, 01006, Spain
  7. 7. Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Vitoria-Gasteiz, Spain
  8. 8. University Institute for Regenerative Medicine and Oral Implantology, UIRMI (UPV/EHU-Fundacion Eduardo Anitua), Vitoria, Spain
  9. 9. Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, Singapore, Singapore
  10. 10. Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands
  11. 11. Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Department of Dentistry - Regenerative Biomaterials, Philips van Leydenlaan 25, Nijmegen, 6525EX, Netherlands

Source: Materials Science and Engineering C Published:2021


Abstract

In bone tissue engineering, ionic doping using bone-related minerals such as magnesium (Mg) or strontium (Sr) is a promising strategy to make up for the inherent disadvantages (low solubility) of various apatite-based materials (such as fluorapatite (FAp) and hydroxyapatite (HA)). Therefore, some studies in recent years have tried to address the lack-of-methodology to improve the properties of bioceramics in the field. Even though the outcome of the studies has shown some promises, the influence of doped elements on the structures and properties of in-vitro and in-vivo mineralized FAp has not been investigated in detail so far. Thus, it is still an open question mark in the field. In this work, strontium modified fluorapatite (Sr-FAp), magnesium and silicon modified fluorapatite (Mg-SiFAp) bioceramics were synthesized using a mechanical alloying methodology. Results showed that the doped elements could decrease the crystallinity of FAp (56%) to less than 45% and 39% for Sr-FAp and Mg-SiFAp, respectively. Moreover, in-vitro studies revealed that Sr-FAp significantly enhanced osteogenic differentiation of hMSCs, after 21 days of culture, compared to Mg-SiFAp at both osteogenic and normal media. Then, in vivo bone formation in a defect of rat femur filled with a Sr-FAp and Mg-SiFAp compared to empty defect was investigated. Histological analysis revealed an increase in bone formation three weeks after implanting Sr-FAp compared to Mg-SiFAp and the empty defect. These results suggest that compared to magnesium and silicon, strontium ion significantly promotes bone formation in fluorapatite, making it appropriate for filling bone defects. © 2020 Elsevier B.V.
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