Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Magnetic Polyvinyl Caprolactam–Polyvinyl Acetate–Polyethylene Glycol Micelles for Docetaxel Delivery in Breast Cancer: An in Vitro Study on Two Cell Lines of Breast Cancer Publisher Pubmed



Varshosaz J1 ; Dehkordi AJ2 ; Setayesh S3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Novel Drug Delivery Systems Research Center, Department of Pharmaceutics, School of Pharmacy, Isfahan University of Medical Science, Isfahan, Iran
  2. 2. Department of Biotechnology, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Pharmaceutics, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Pharmaceutical Development and Technology Published:2017


Abstract

The aim of the present study was to load docetaxel (DCT) and Fe3O4 magnetic nanoparticles (MNPs) in polymeric micelles to concentrate them by an external magnetic field in target tissues. Oleic acid (OA) coated MNPs were prepared by hydrothermal method. The micelles were characterized for their zeta potential, particle size, drug loading and release efficacy. Fe loading efficacy was determined by atomic absorption. The magnetic micelles were characterized by Fourier transform infrared (FT-IR) spectroscopy, thermogravimetric analysis (TGA), transmission electron microscopy and vibrating sample magnetometer (VSM). The cytotoxicity of the micelles was studied by MTT assay on L929 fibroblast cells and also on two breast cancer cell lines of MCF-7 and MDA-MB-231. The optimum formulation showed 70% drug loading efficiency, zeta potential of −2.58 mV, particle size of 144.3 nm and drug release efficiency within 24 h of 68.9% at pH 5.5. Fe was loaded in these nanomicelles 290 μg/100 ml. TGA results confirmed the coating of MNPs with OA and polymeric micelles. The VSM analysis confirmed superparamagnetic property of the micelles. DCT loaded in micelles showed significantly more cytotoxicity compared to free drug on MCF-7 and MDA-MB-231 cells, but blank magnetic micelles had no significant cytotoxicity on normal fibroblast cells. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Related Docs
View other Related Docs
1. Use of Magnetic Folate-Dextran-Retinoic Acid Micelles for Dual Targeting of Doxorubicin in Breast Cancer, BioMed Research International (2013)
2. Targeted Delivery of Doxorubicin to Breast Cancer Cells by Magnetic Lhrh Chitosan Bioconjugated Nanoparticles, International Journal of Biological Macromolecules (2016)
3. Mtx-Loaded Dual Thermoresponsive and Ph-Responsive Magnetic Hydrogel Nanocomposite Particles for Combined Controlled Drug Delivery and Hyperthermia Therapy of Cancer, Molecular Pharmaceutics (2021)
4. Synthesis, in Vitro Characterization, and Anti-Tumor Effects of Novel Polystyrene-Poly(Amide-Ether-Ester-Imide) Co-Polymeric Micelles for Delivery of Docetaxel in Breast Cancer in Balb/C Mice, Drug Development and Industrial Pharmacy (2018)
5. Folated Synperonic-Cholesteryl Hemisuccinate Polymeric Micelles for the Targeted Delivery of Docetaxel in Melanoma, BioMed Research International (2015)
6. Functionalized Magnetic Nanoparticles for Cancer Therapy, Functionalized Nanomaterials for Cancer Research: Applications in Treatments, Tools and Devices (2024)
7. Optimisation of Processing Variables Effective on Self-Assembly of Folate Targeted Synpronic-Based Micelles for Docetaxel Delivery in Melanoma Cells, IET Nanobiotechnology (2015)
8. Preparation and Cytotoxic Evaluation of Magnetite (Fe3o4) Nanoparticleon Breast Cancer Cells and Its Combinatory Effects With Doxorubicin Used in Hyperthermia, Avicenna Journal of Medical Biotechnology (2013)
Experts (# of related papers)
View all Related Experts
Jaleh Varshosaz (58)
Farshid Hassanzadeh (32)
Other Related Docs
9. Synthesis of Biotin-Targeted Chitosan/Poly (Methyl Vinyl Ether- Alt -Maleic Acid) Copolymeric Micelles for Delivery of Doxorubicin, IET Nanobiotechnology (2017)
10. In Vitro Study of Spions-C595 As Molecular Imaging Probe for Specific Breast Cancer (Mcf-7) Cells Detection, Iranian Biomedical Journal (2017)
11. Folic Acid Targeted Polymeric Micelles Based on Tocopherol Succinate-Pulluan As an Effective Carrier for Epirubicin: Preparation, Characterization and In-Vitro Cytotoxicity Assessment, Current Drug Delivery (2018)
12. Biotin-Targeted Nanomicellar Formulation of an Anderson-Type Polyoxomolybdate: Synthesis and in Vitro Cytotoxicity Evaluations, Langmuir (2021)
13. Polyacrylamide-Punicic Acid Conjugate-Based Micelles for Flutamide Delivery in Pc3 Cells of Prostate Cancer: Synthesis, Characterisation and Cytotoxicity Studies, IET Nanobiotechnology (2020)
14. Multifunctional Magnetic Nanostructured Hardystonite Scaffold for Hyperthermia, Drug Delivery and Tissue Engineering Applications, Materials Science and Engineering C (2017)
15. Novel Ph-Triggered Biocompatible Polymeric Micelles Based on Heparin–Α-Tocopherol Conjugate for Intracellular Delivery of Docetaxel in Breast Cancer, Pharmaceutical Development and Technology (2020)
16. An Investigation on Polycaprolactone/Chitosan/Fe3o4 Nanofibrous Composite Used for Hyperthermia, Polymers for Advanced Technologies (2019)
17. Synthesis and Cytotoxicity Assessment of Gold-Coated Magnetic Iron Oxide Nanoparticles, Journal of Biomedical Physics and Engineering (2018)
18. Fabrication of a Biocompatible & Biodegradable Targeted Theranostic Nanocomposite With Ph-Controlled Drug Release Ability, Journal of Drug Delivery Science and Technology (2022)
19. Chitosan As Possible Inhibitory Agents and Delivery Systems in Leukemia, Cancer Cell International (2021)
20. In Vivo Study of Anti-Epidermal Growth Factor Receptor Antibody-Based Iron Oxide Nanoparticles (Anti-Egfr-Spions) As a Novel Mr Imaging Contrast Agent for Lung Cancer (Llc1) Cells Detection, IET Nanobiotechnology (2020)
21. Cobalt Zinc Ferrite Nanoparticles As a Potential Magnetic Resonance Imaging Agent: An in Vitro Study, Avicenna Journal of Medical Biotechnology (2015)
22. Lomustine Loaded Superparamagnetic Iron Oxide Nanoparticles Conjugated With Folic Acid for Treatment of Glioblastoma Multiforma (Gbm), Iranian Journal of Pharmaceutical Research (2020)
23. A Theranostic System Based on Nanocomposites of Manganese Oxide Nanoparticles and a Ph Sensitive Polymer: Preparation, and Physicochemical Characterization, Bioelectrochemistry (2019)
24. Self-Assembly Micelles With Lipid Core of Cholesterol for Docetaxel Delivery to B16f10 Melanoma and Hepg2 Cells, Journal of Liposome Research (2015)
25. A Drug Delivery System Based on Nanocomposites Constructed From Metal-Organic Frameworks and Mn3o4 Nanoparticles: Preparation and Physicochemical Characterization for Bt-474 and Mcf-7 Cancer Cells, Colloids and Surfaces B: Biointerfaces (2021)
26. Synthesis and Characterisation of Iron Oxide Nanoparticles Conjugated With Epidermal Growth Factor Receptor (Egfr) Monoclonal Antibody As Mri Contrast Agent for Cancer Detection, IET Nanobiotechnology (2019)
27. Cytotoxic Effect of Pluronic F127-Poly (Methyl Vinyl Ether-Alt-Maleic Acid) Micelles Loaded With Doxorubicin on Mcf-7 Cells, Journal of Isfahan Medical School (2013)
28. Breast Cancer Cell Targeted Mr Molecular Imaging Probe: Anti-Muc1 Antibody-Based Magnetic Nanoparticles, Journal of Physics: Conference Series (2017)
29. Synthesis and in Vitro/In Vivo Characterization of Raloxifene Grafted Poly(Styrene Maleic Acid)-Poly(Amide-Ether-Ester-Imide) Micelles for Targeted Delivery of Docetaxel in G Protein-Coupled Estrogen Receptor Breast Cancer, Anti-Cancer Agents in Medicinal Chemistry (2018)
30. Pulmonary Delivery of Triptorelin Loaded in Pluronic Based Nanomicelles in Rat Model, Current Drug Delivery (2018)
31. Fabrication of Poly Hydroxybutyrate-Polyethylene Glycol-Folic Acid Nanoparticles Loaded by Paclitaxel, Current Drug Delivery (2016)
32. Doxorubicin Hydrochloride - Loaded Electrospun Chitosan/Cobalt Ferrite/Titanium Oxide Nanofibers for Hyperthermic Tumor Cell Treatment and Controlled Drug Release, International Journal of Biological Macromolecules (2018)
33. Facile, Rapid and Efficient Isolation of Circulating Tumor Cells Using Aptamer-Targeted Magnetic Nanoparticles Integrated With a Microfluidic Device, RSC Advances (2022)
34. Functionalized Magnetic Nanoparticles for the Detection and Quantitative Analysis of Cell Surface Antigen, BioMed Research International (2013)
35. Biotin-Encoded Pullulan-Retinoic Acid Engineered Nanomicelles: Preparation, Optimization and in Vitro Cytotoxicity Assessment in Mcf-7 Cells, Indian Journal of Pharmaceutical Sciences (2016)
36. Versatile Theranostics Agents Designed by Coating Ferrite Nanoparticles With Biocompatible Polymers, Nanotechnology (2016)
37. Development and Optimization of Transferrin-Conjugated Nanostructured Lipid Carriers for Brain Delivery of Paclitaxel Using Box–Behnken Design, Pharmaceutical Development and Technology (2017)
38. A New Path in Bone Tissue Engineering: Polymer-Based 3D-Printed Magnetic Scaffolds (A Comprehensive Review of in Vitro and in Vivo Studies), Journal of Biomaterials Science, Polymer Edition (2024)
39. Pharmacokinetics, Organ Toxicity and Antitumor Activity of Docetaxel Loaded in Folate Targeted Cholesterol Based Micelles, Current Drug Delivery (2016)
40. Pegylated Multifunctional Ph-Responsive Targeted Polymeric Micelles for Ovarian Cancer Therapy: Synthesis, Characterization and Pharmacokinetic Study, International Journal of Polymeric Materials and Polymeric Biomaterials (2021)
41. Design, Synthesis, and Comparison of Pla-Peg-Pla and Peg-Pla-Peg Copolymers for Curcumin Delivery to Cancer Cells, Polymers (2023)
42. Docetaxel-Loaded Nanostructured Lipid Carriers Functionalized With Trastuzumab (Herceptin) for Her2-Positive Breast Cancer Cells, Journal of Liposome Research (2018)
43. Synthesis and Characterization of Folate-Targeted Dextran/Retinoic Acid Micelles for Doxorubicin Delivery in Acute Leukemia, BioMed Research International (2014)
44. Development and Optimization of Solid Lipid Nanoparticles of Amikacin by Central Composite Design, Journal of Liposome Research (2010)
45. Ph-Responsive Glucosamine Anchored Polydopamine Coated Mesoporous Silica Nanoparticles for Delivery of Anderson-Type Polyoxomolybdate in Breast Cancer, Journal of Microencapsulation (2022)
46. 5Fu-Loaded Pcl/Chitosan/Fe3o4 Core-Shell Nanofibers Structure: An Approach to Multi-Mode Anticancer System, Advanced Pharmaceutical Bulletin (2022)
47. Superparamagnetic Iron Oxide-C595: Potential Mr Imaging Contrast Agents for Ovarian Cancer Detection, Journal of Medical Physics (2013)
48. Peptide-Based Pegylated Polyurethane Nanoparticles for Paclitaxel Delivery in Hela Cancer Cells: The Art of the Architecture Design in Nanocarriers, Polymer Bulletin (2023)
49. Could Fa-Pg-Spions Act As a Hyperthermia Sensitizing Agent? an in Vitro Study, Journal of Thermal Biology (2018)
50. Hydroxypyridinone Derivatives: Synthesis and Cytotoxic Evaluation, Journal of Reports in Pharmaceutical Sciences (2013)