The Correlation Between Flt3-Itd Mutation in Dendritic Cells With Tim-3 Expression in Acute Myeloid Leukemia

The Correlation Between Flt3-Itd Mutation in Dendritic Cells With Tim-3 Expression in Acute Myeloid Leukemia Publisher

Shapoorian H¹ ; Zalpoor H² ; Ganjalikhanihakemi M^{1, 3}

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1. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2. Paramedical School, Shiraz University of Medical Sciences, Shiraz, Iran
3. Acquired Immunodeficiency Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Blood Science Published:2021

Abstract

In general, acute myeloid leukemia (AML) is an aggressive and heterogeneous disease that is characterized by rapid cellular proliferation and high mortality. One of the mutations related to AML is the Flt3-ITD mutation, which is found in approximately 25% of patients. In this mini-review, we investigate the function of dendritic cells and T cells based on Flt3-ITD mutation and immune evasion as a result of this abnormality. Finally, we discuss some AML therapeutic strategies, including targeting Flt3 on DCs and TIM-3 on T cells as immune receptors to treat this hematopoietic malignancy. © 2021 De Gruyter Open Ltd. All rights reserved.

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Mazdak Ganjalikhani Hakemi (7)

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Style	Citing Format
MLA	Shapoorian H, Zalpoor H, Ganjalikhanihakemi M. "The Correlation Between Flt3-Itd Mutation in Dendritic Cells With Tim-3 Expression in Acute Myeloid Leukemia." Blood Science, vol. 3, no. 4, 2021, pp. 132-135.
APA	Shapoorian H, Zalpoor H, Ganjalikhanihakemi M (2021). The Correlation Between Flt3-Itd Mutation in Dendritic Cells With Tim-3 Expression in Acute Myeloid Leukemia. Blood Science, 3(4), 132-135.
Chicago	Shapoorian H, Zalpoor H, Ganjalikhanihakemi M. "The Correlation Between Flt3-Itd Mutation in Dendritic Cells With Tim-3 Expression in Acute Myeloid Leukemia." Blood Science 3, no. 4 (2021): 132-135.
Harvard	Shapoorian H, Zalpoor H, Ganjalikhanihakemi M (2021) 'The Correlation Between Flt3-Itd Mutation in Dendritic Cells With Tim-3 Expression in Acute Myeloid Leukemia', Blood Science, 3(4), pp. 132-135.
Vancouver	Shapoorian H, Zalpoor H, Ganjalikhanihakemi M. The Correlation Between Flt3-Itd Mutation in Dendritic Cells With Tim-3 Expression in Acute Myeloid Leukemia. Blood Science. 2021;3(4):132-135.
BibTex	@article{ author = {Shapoorian H and Zalpoor H and Ganjalikhanihakemi M}, title = {The Correlation Between Flt3-Itd Mutation in Dendritic Cells With Tim-3 Expression in Acute Myeloid Leukemia}, journal = {Blood Science}, volume = {3}, number = {4}, pages = {132-135}, year = {2021} }
RIS	TY - JOUR AU - Shapoorian H AU - Zalpoor H AU - Ganjalikhanihakemi M TI - The Correlation Between Flt3-Itd Mutation in Dendritic Cells With Tim-3 Expression in Acute Myeloid Leukemia JO - Blood Science VL - 3 IS - 4 SP - 132 EP - 135 PY - 2021 ER -

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