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Molecular Biology, Genetic, and Epigenetics of Kidney Tumor Publisher



Kazemi R1 ; Rezaeian AR2 ; Deyhimfar R2 ; Taheri D2, 3
Authors
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Authors Affiliations
  1. 1. Department of Urology, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pathology, Isfahan Kidney Disease Research Center, Isfahan University of Medical Sciences, Tehran, Isfahan, Iran

Source: Genetics and Epigenetics of Genitourinary Diseases Published:2024


Abstract

Kidneys are bean-shaped organs located just below the ribcage and behind the belly. Kidney cancer is a fatal and common urological cancer mostly diagnosed in developed countries. The cancer includes renal cell carcinoma as the principal type, urothelial carcinoma, renal sarcoma, Wilms tumor, etc. These diseases have different pathologies, predisposing genes, clinical manifestations, and managements. Hereditary or acquired changes in tumor suppressor genes, oncogenes, and DNA damage repair genes can lead to kidney cancer development. Investigating specific genetic changes and biomarkers helps physicians and researchers predict prognosis and plan therapeutic strategies. In this chapter, we intend to investigate renal tumors in molecular and genetic basis. © 2025 Elsevier Inc. All rights are reserved including those for text and data mining AI training and similar technologies.
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