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Ldl Fatty Acids Composition As a Risk Biomarker of Cardiovascular Disease Publisher



Nayeri H1 ; Naderi GA2 ; Asgari S3 ; Sadeghi M2 ; Boshtam M3 ; Mohamadzadeh S4 ; Babaknejad N1, 5
Authors
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Authors Affiliations
  1. 1. Department of Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
  2. 2. Cardiovascular Research Institute, Cardiac Rehabilitation Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Cardiovascular Research Institute, Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Biochemistry, Faculty of Science, Shahrekord University, Shahrekord, Iran

Source: Artery Research Published:2017


Abstract

Objective Fatty acid composition of Low-density lipoprotein (LDL) particle is an effective factor in LDL oxidation and atherosclerotic plaques formation. This study evaluates the relationship between LDL fatty acid composition and coronary artery disease (CAD). Methods 42 men with coronary artery disease (CAD-group) and 40 men without coronary artery disease (non-CAD-group) were selected. LDL fatty acid composition of blood samples was measured by gas chromatography. Results Ox-LDL was significantly high in CAD-group. Poly unsaturated fatty acids (PUFA) and PUFA/MUFA (Mono unsaturated fatty acids), linoleic acid and arachidonic acid were significantly higher in CAD-group than in non-CAD-group. In CAD-group, a reverse correlation was observed between oleic acid concentrations and ox-LDL levels and a direct correlation was seen between arachidonic acid concentrations and ox-LDL levels. Conclusion Composition of LDL is related to atherosclerosis and CAD. High levels of arachidonic and linoleic acids could increase LDL oxidation and atherosclerotic plaques formation. In addition, LDL arachidonic acid levels could be a better predictor of CAD. © 2017 Association for Research into Arterial Structure and Physiology
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