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Association Between the Fabp2 Ala54thr and Crp+1059C/G Polymorphisms and Small Dense Ldl Level in Patients With Atherosclerosis: A Case–Control Study Publisher Pubmed



Yalameha B1 ; Birjandi M2 ; Nouryazdan N1 ; Nasri H3 ; Shahsavari G1
Authors
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Authors Affiliations
  1. 1. Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
  2. 2. Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
  3. 3. Department of Internal Medicine, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Archives of Physiology and Biochemistry Published:2023


Abstract

Background: The polymorphisms of fatty acid-binding protein 2 (FABP2) and C-reactive protein (CRP) might act as genetic risk factors for atherosclerosis. The study aimed to investigate the relationship between FABP2 Ala54Thr and CRP+1059C/G polymorphisms and atherosclerosis as well as the association of Small dense-LDL (sd-LDL). Methods: A total of 255 subjects (125 controls and 130 patients) were included. The FABP2 and CRP polymorphisms were determined by PCR-RFLP and AS-PCR methods, respectively. Sd-LDL was measured based on Hirano et al method. Results: There were no significant distinctions between the patient and control groups concerning FABP2 and CRP polymorphisms (p >.05). No significant relationship was observed between studied polymorphisms and sd-LDL level in the patient group (p >.05). However, patients group had higher level of sd-LDL compared to controls (p <.05). Conclusion: FABP2 Ala54Thr and CRP+1059G/C polymorphisms were not associated with atherosclerosis and sd-LDL level. However, the increased sd-LDL level was known as a risk factor for atherosclerosis. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
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