Association Between the Fabp2 Ala54thr and Crp+1059C/G Polymorphisms and Small Dense Ldl Level in Patients With Atherosclerosis: A Case–Control Study Publisher Pubmed



Yalameha B¹ ; Birjandi M² ; Nouryazdan N¹ ; Nasri H³ ; Shahsavari G¹
Source: Archives of Physiology and Biochemistry Published:2023

Abstract

Background: The polymorphisms of fatty acid-binding protein 2 (FABP2) and C-reactive protein (CRP) might act as genetic risk factors for atherosclerosis. The study aimed to investigate the relationship between FABP2 Ala54Thr and CRP+1059C/G polymorphisms and atherosclerosis as well as the association of Small dense-LDL (sd-LDL). Methods: A total of 255 subjects (125 controls and 130 patients) were included. The FABP2 and CRP polymorphisms were determined by PCR-RFLP and AS-PCR methods, respectively. Sd-LDL was measured based on Hirano et al method. Results: There were no significant distinctions between the patient and control groups concerning FABP2 and CRP polymorphisms (p >.05). No significant relationship was observed between studied polymorphisms and sd-LDL level in the patient group (p >.05). However, patients group had higher level of sd-LDL compared to controls (p <.05). Conclusion: FABP2 Ala54Thr and CRP+1059G/C polymorphisms were not associated with atherosclerosis and sd-LDL level. However, the increased sd-LDL level was known as a risk factor for atherosclerosis. © 2020 Informa UK Limited, trading as Taylor & Francis Group.