Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Study of Circadian Rhythms Disorder and Its Relationship With Chronic Fatigue in Multiple Sclerosis in Compare With Control Group



Najafi MR1 ; Etemadifar M1 ; Haghighi S2 ; Maghzi AH2 ; Akbari M2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2011

Abstract

Background: Circadian rhythm disorders (CRDs) are one of the manifestations of all types of sleep disorders in Multiple Sclerosis (MS) patients. Knowing about these problems and rationale approach to them can increase the health level and treat these patients. The aim of this study was to determine the frequency of circadian rhythm disorders in MS patients in compare with control group and ascertain its association with chronic fatigability. Methods: The case-control study was held on 120 Multiple sclerosis patients and 60 healthy people (as control group) in MS Clinic of Al-Zahra Hospital in Isfahan in 2009. The questionnaires of PSQI, FSS and EDSS was given to patients and for assessing the circadian rhythm disorders, the PSQI questionnaire was given to control group too. All the findings were analyzed in SPSS software. Finding: The amount of circadian rhythm disorders in MS patients was significantly higher than control group (P = 0.002). In this manner, these kind of circadian rhythm disorders in patients with severe fatigue was significantly higher than patients with mild fatigue (P < 0.05). Conclusion: This study showed that the rate of circadian rhythm disorders in MS patients with severe and mild fatigue was higher than control group. Increased distribution of these groups of disorders may empower the more susceptibility of biologic clock, which regulates the circadian rhythm, in the course of MS disease. More studies are required for confirmation of anatomic relationship between location of demyelinative plaque and types of sleep disorders.
Related Docs
View other Related Docs
1. Circadian Rhythm Sleep Disorders in Patients With Multiple Sclerosis and Its Association With Fatigue: A Case-Control Study, Journal of Research in Medical Sciences (2013)
2. Comparison of Prevalence Rates of Restless Legs Syndrome, Self-Assessed Risks of Obstructive Sleep Apnea, and Daytime Sleepiness Among Patients With Multiple Sclerosis (Ms), Clinically Isolated Syndrome (Cis) and Neuromyelitis Optica Spectrum Disorder (Nmosd), Sleep Medicine (2020)
3. Comparing the Effects of Reflexology and Relaxation on Fatigue in Women With Multiple Sclerosis, Iranian Journal of Nursing and Midwifery Research (2015)
4. In Patients With Multiple Sclerosis, Both Objective and Subjective Sleep, Depression, Fatigue, and Paresthesia Improved After 3 Weeks of Regular Exercise, Frontiers in Psychiatry (2019)
5. Stability of Mental Toughness, Sleep Disturbances, and Physical Activity in Patients With Multiple Sclerosis (Ms)-A Longitudinal and Pilot Study, Frontiers in Psychiatry (2018)
6. Multiple Sclerosis-Related Fatigue Lacks a Unified Definition: A Narrative Review, Journal of Research in Medical Sciences (2022)
7. The Effectiveness of Mindfulness-Based Stress Reduction on Sleep Quality in Patients With Multiple Sclerosis, Caspian Journal of Neurological Sciences (2024)
8. Comparison of Sleep Complaints and Quality of Life Between Patients With Neuromyelitis Optica Spectrum Disorder (Nmosd) and Healthy Controls, Multiple Sclerosis and Related Disorders (2019)
Experts (# of related papers)
View all Related Experts
Vahid Shaygannejad (57)
Masoud Etemadifar (33)
Other Related Docs
9. Fatigue, Depression, and Health-Related Quality of Life in Patients With Multiple Sclerosis in Isfahan, Iran, European Journal of Neurology (2012)
10. Effectiveness of Cognitive Behavioral Therapy on the Quality of Sleep in Women With Multiple Sclerosis: A Randomized Controlled Trial Study, International Journal of Community Based Nursing and Midwifery (2016)
11. Effects of Prolonged Fasting on Fatigue and Quality of Life in Patients With Multiple Sclerosis, Neurological Sciences (2016)
12. Mental Toughness, Sleep Disturbances, and Physical Activity in Patients With Multiple Sclerosis Compared to Healthy Adolescents and Young Adults, Neuropsychiatric Disease and Treatment (2016)
13. Is Sleep Quality Associated With Restless Legs Syndrome in Patients Suffering From Multiple Sclerosis?, Shiraz E Medical Journal (2017)
14. Clinical and Demographical Characteristics of Primary Progressive Multiple Sclerosis in Isfahan, Iran, European Journal of Neurology (2007)
15. Demographic and Clinical Characteristics of Familial and Sporadic Multiple Sclerosis Patients, International Journal of Preventive Medicine (2023)
16. Epidemiology of Multiple Sclerosis in Iran: A Systematic Review, European Neurology (2013)
17. Prevalence of Hypothyroidism Among Patients With Multiple Sclerosis Referred to Multiple Sclerosis Clinic of Alzahra Hospital, Isfahan, Iran, During 2014-2015, Journal of Isfahan Medical School (2016)
18. Serum Mercury Level and Multiple Sclerosis, Biological Trace Element Research (2012)
19. Risk Factors of Multiple Sclerosis and Their Relation With Disease Severity: A Cross-Sectional Study From Iran, Archives of Iranian Medicine (2016)
20. Thalamic Asymmetry in Multiple Sclerosis, Multiple Sclerosis and Related Disorders (2023)
21. Association of Latitude and Exposure to Ultraviolet B Radiation With Severity of Multiple Sclerosis: An International Registry Study, Neurology (2022)
22. Prescription Trends of Disease-Modifying Treatments for Multiple Sclerosis in Iran Over the Past 30 Years, Multiple Sclerosis and Related Disorders (2022)
23. Co-Supplementation of Synbiotics and Anti-Inflammatory-Antioxidant Rich Diet in Patients With Progressive Forms of Multiple Sclerosis: A Single-Center, Randomized Clinical Trial, Mediterranean Journal of Nutrition and Metabolism (2024)
24. The Effect of Mindfulness-Based Stress Reduction (Mbsr) Therapy on Quality of Life in Women With Multiple Sclerosis, Ahvaz, Iran, Journal of Caring Sciences (2019)
25. Seizure in Iranian Patients With Multiple Sclerosis, Journal of Research in Medical Sciences (2013)
26. Comparison of the Effect of Aspirin and Amantadine for the Treatment of Fatigue in Multiple Sclerosis: A Randomized, Blinded, Crossover Study, Neurological Research (2012)
27. The Association Between Multiple Sclerosis and Migraine: A Meta-Analysis, Multiple Sclerosis and Related Disorders (2023)
28. The Frequency of Cognitive Dysfunction Among Multiple Sclerosis Patients With Mild Physical Disability, Journal of Isfahan Medical School (2012)
29. Comparing Body Image in Ms Patients and Healthy Individuals, International Journal of Body, Mind and Culture (2020)
30. The Prevalence of Restless Legs Syndrome (Rls) in Patients With Multiple Sclerosis (Ms): A Systematic Review and Meta-Analysis—An Update, Neurological Sciences (2023)
31. Association of Initial Disease-Modifying Therapy With Later Conversion to Secondary Progressive Multiple Sclerosis, JAMA - Journal of the American Medical Association (2019)
32. The Global Prevalence of Familial Multiple Sclerosis: An Updated Systematic Review and Meta-Analysis, BMC Neurology (2021)
33. Prevalence of Cognitive Impairment (Ci) in Patients With Multiple Sclerosis (Ms): A Systematic Review and Meta-Analysis, Caspian Journal of Internal Medicine (2024)
34. Prevalence of Multiple Sclerosis (Ms) in Iran: A Systematic Review and Meta-Analysis, Neurological Sciences (2022)
35. Comparative Study of Quality of Life, Anxiety, Depression, and Fatigue Among Patients With Neuromyelitis Optica Spectrum Disorder and Multiple Sclerosis: The First Report From Iran, Multiple Sclerosis and Related Disorders (2018)
36. Late-Onset Multiple Sclerosis in Iran: A Report on Demographic and Disease Characteristics, Multiple Sclerosis and Related Disorders (2023)
37. Side Effects of Methylprednisolone Pulse Therapy in Treatment of Multiple Sclerosis, Journal of Isfahan Medical School (2012)
38. Islamic Fasting and Multiple Sclerosis, BMC Neurology (2014)
39. Higher Latitude Is Significantly Associated With an Earlier Age of Disease Onset in Multiple Sclerosis, Journal of Neurology, Neurosurgery and Psychiatry (2016)
40. A Comparison of Linear and Nonlinear Stability Parameters in Different Clinical Forms of Multiple Sclerosis, European Review of Aging and Physical Activity (2015)
41. Comparison of Energy Consumption in Different Clinical Forms Multiple Sclerosis With Normal Subjects (Cohort Study), Multiple Sclerosis and Related Disorders (2016)
42. Time Interval Between the Onset of Symptoms and Diagnosis of Multiple Sclerosis and the Influential Factors: A National Registry-Based Study, Clinical Neurology and Neurosurgery (2024)
43. Stress Differentially Predicts Multiple Sclerosis Relapses, Neurology Asia (2014)
44. Male Sex Is Independently Associated With Faster Disability Accumulation in Relapse-Onset Ms But Not in Primary Progressive Ms, PLoS ONE (2015)
45. Clinical and Epidemiological Aspects of Multiple Sclerosis in Children, Iranian Journal of Child Neurology (2017)
46. Prevalence of Dysphagia in Patients With Multiple Sclerosis: A Systematic Review and Meta-Analysis, Journal of Clinical Neuroscience (2023)
47. Does Early-Onset Multiple Sclerosis Differ From Adult-Onset Form in Iranian People, Journal of Research in Medical Sciences (2010)
48. Prevalence and Risk Factors of Dysphagia in Patients With Multiple Sclerosis, Dysphagia (2022)
49. Epidemiology of Familial Multiple Sclerosis in Iran: A National Registry-Based Study, BMC Neurology (2022)
50. Patterns of Attention Deficit in Relapsing and Progressive Phenotypes of Multiple Sclerosis, Scientific Reports (2023)