Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Prevalence of Metabolic Syndrome in First Degree Relatives of Patients With Obstructive Sleep Apnea Syndrome: A Case-Control Study Publisher



Amra B1 ; Shafiei A2 ; Soltaninejad F3 ; Asgari A2 ; Farajzadegan Z4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Internal Medicine, Bamdad Respiratory and Sleep Research Center, Pulmonary Unit, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Internal Medicine, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Internal Medicine, Respiratory and Sleep Research Center, Pulmonary Unit, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Community and Preventive Medicine, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Journal of Preventive Medicine Published:2022


Abstract

Background: There was the association between the metabolic syndrome (MS) and obstructive sleep apnea (OSA). Also, the genetic factors have been implicated in the OSA. Our aim was to compare the frequency of MS in first-degree relatives (FDRs) of OSA patients with healthy controls. Methods: 39 FDR (parents, siblings, and children) of patients diagnosed with OSA at Bamdad Respiratory and Research Center as cases and age-and sex-matched healthy controls were included in the current case-control pilot study. The sampling method was convenience sampling based on having inclusion criteria and consent to participate in the study. Demographic characteristics and essential criteria for diagnosing MS included blood pressure, anthropometric [weight (kg), height (cm), waist circumference (cm) and body mass index (BMI) (kg/m 2)], and biochemical indices (lipid profile and blood glucose) were assessed based on standard protocols. Results: In the comparison of the demographic and clinical characteristics of two39 cases and control groups, weight and diastolic blood pressure were significantly higher in case group than controls (P < 0.05). Case and control groups were not significantly different in the frequency of MS (P > 0.05). Although, the frequency of hypertension as an important cardiovascular risk factor was higher in cases than controls (P < 0.05). Conclusions: The present study demonstrates that the frequency of MS is not significantly different between FDRs of OSA patients and controls. However, further large-scale studies are warranted to detect the frequency of MS in people with hereditary background for OSA compared to general population. © 2022 American Institute of Physics Inc.. All rights reserved.
Related Docs
View other Related Docs
1. Comparison of Berlin Questionnaire, Stop-Bang, and Epworth Sleepiness Scale for Diagnosing Obstructive Sleep Apnea in Persian Patients, International Journal of Preventive Medicine (2018)
2. Effect of Cpap Therapy on Serum Lipids and Blood Pressure in Patients With Obstructive Sleep Apnea Syndrome, Tanaffos (2019)
3. Metabolic Syndrome in Ischemic Stroke: A Case Control Study, Journal of Research in Medical Sciences (2012)
4. Evaluation of Plasma/Serum Adiponectin (An Anti-Inflammatory Factor) Levels in Adult Patients With Obstructive Sleep Apnea Syndrome: A Systematic Review and Meta-Analysis, Life (2022)
5. Factors Associated With the Metabolic Syndrome in a National Sample of Youths: Caspian Study, Nutrition, Metabolism and Cardiovascular Diseases (2008)
6. Screening Tools for Obstructive Sleep Apnea in Pregnant Women: An Extended and Updated Systematic Review and Meta‑Analysis, International Journal of Preventive Medicine (2024)
7. Association Between Sleep Duration and Metabolic Syndrome in a Population-Based Study: Isfahan Healthy Heart Program, Journal of Research in Medical Sciences (2011)
8. Obstructive Sleep Apnea, Diagnosed by the Berlin Questionnaire and Association With Coronary Artery Disease Severity, ARYA Atherosclerosis (2015)
Experts (# of related papers)
View all Related Experts
Roya Kelishadi (23)
Nizal Sarrafzadegan (16)
Other Related Docs
9. The Characteristics of Uterine Leiomyoma and Metabolic Syndrome in the Multiparous Overweight Women in Northern Iran, Pakistan Journal of Medical and Health Sciences (2020)
10. Effect of Mediterranean Diet on Body Mass Index and Fatigue Severity in Patients With Multiple Sclerosis: A Systematic Review and Meta-Analysis of Clinical Trials, Heliyon (2024)
11. Effects of Probiotic Supplementation on Anthropometric and Metabolic Characteristics in Adults With Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Clinical Trials, Clinical Nutrition (2021)
12. Investigation of Symptoms and Risk Factors of Obstructive Sleep Apnea Among Patients With Acute Stroke Who Were Hospitalized in Alzahra Hospital, Isfahan, Iran, During 2014, Journal of Isfahan Medical School (2016)
13. Metabolic Syndrome and Associated Factors in Iranian Children and Adolescents: The Caspian-V Study, Journal of Cardiovascular and Thoracic Research (2018)
14. Diet in Relation to Metabolic, Sleep and Psychological Health Status (Dimets): Protocol for a Cross-Sectional Study, BMJ Open (2023)
15. Association of Dietary Behaviors, Biochemical, and Lifestyle Factors With Metabolic Phenotypes of Obesity in Children and Adolescents, Diabetology and Metabolic Syndrome (2020)
16. Predictors of Metabolic Syndrome in the Iranian Population: Waist Circumference, Body Mass Index, or Waist to Hip Ratio?, Cholesterol (2013)
17. Association Between Heme Oxygenase-1 Gene Promoter Polymorphisms and Metabolic Syndrome in Iranians, Molecular Biology Reports (2012)
18. Smartphone Addiction and Obstructive Sleep Apnea Syndrome: An Evaluation of the Possible Association, Journal of Health Sciences and Surveillance System (2022)
19. Comparison of Prevalence Rates of Restless Legs Syndrome, Self-Assessed Risks of Obstructive Sleep Apnea, and Daytime Sleepiness Among Patients With Multiple Sclerosis (Ms), Clinically Isolated Syndrome (Cis) and Neuromyelitis Optica Spectrum Disorder (Nmosd), Sleep Medicine (2020)
20. Association of Anthropometric Measures With Cardiovascular Risk Factors and Metabolic Syndrome in Normal-Weight Children and Adolescents: The Caspian Iii Study, Obesity Facts (2013)
21. The Prediction of Obstructive Sleep Apnea Severity Based on Anthropometric and Mallampati Indices, Journal of Research in Medical Sciences (2019)
22. Association of Dietary Pattern and Metabolic Syndrome in 15- to 49-Years-Old Women, Journal of Isfahan Medical School (2015)
23. Association of Anthropometric Indices With Continuous Metabolic Syndrome in Children and Adolescents: The Caspian-V Study, Eating and Weight Disorders (2018)
24. Anthropometric Indicators of Adiposity Related to Body Weight and Body Shape As Cardiometabolic Risk Predictors in British Young Adults: Superiority of Waist-To-Height Ratio, Journal of Obesity (2018)
25. Incidence of Metabolic Syndrome and Its Risk Factors Among Type 2 Diabetes Clinic Attenders in Isfahan, Iran, Endokrynologia Polska (2012)
26. The Relationship Between Hematologic Variables and Metabolic Syndrome, Iranian Heart Journal (2011)
27. Metabolic Syndrome in First Degree Relatives of Patients With Type 2 Diabetes: Incidence and Risk Factors, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2011)
28. Risk of Diabetes According to the Metabolic Health Status and Degree of Obesity, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2017)
29. Gender Difrances on Polysomographic Findings and Clinical Symptome in Iranian Subjects With Obstructive Sleep Apnea Syndrome, Journal of Isfahan Medical School (2011)
30. Comparison of Body Mass Index With Abdominal Obesity Indicators and Waist-To-Stature Ratio for Prediction of Type 2 Diabetes: The Isfahan Diabetes Prevention Study, Obesity Research and Clinical Practice (2010)
31. A Systematic Review With Meta-Analysis to Assess Alzheimer's Disease Biomarkers in Adults With or Without Obstructive Sleep Apnoea, International Orthodontics (2023)
32. Obesity and Metabolic Syndrome Among a Representative Sample of Iranian Adolescents, Southeast Asian Journal of Tropical Medicine and Public Health (2012)
33. Comparative Evaluation of Therapeutic Approaches to Central Sleep Apnea, Advanced Biomedical Research (2019)
34. Circadian Rhythm Sleep Disorders in Patients With Multiple Sclerosis and Its Association With Fatigue: A Case-Control Study, Journal of Research in Medical Sciences (2013)
35. Neighbourhood Socioeconomic Status and Overweight/Obesity: A Systematic Review and Meta-Analysis of Epidemiological Studies, BMJ Open (2019)
36. The Global Prevalence of Familial Multiple Sclerosis: An Updated Systematic Review and Meta-Analysis, BMC Neurology (2021)
37. Tri-Ponderal Mass Index and Body Mass Index in Prediction of Pediatric Metabolic Syndrome: The Caspian-V Study, Archives of Endocrinology and Metabolism (2020)
38. Association of Glycaemic Index and Glycaemic Load With Metabolic Syndrome in an Iranian Adult Population: Isfahan Healthy Heart Program, Nutrition and Dietetics (2017)
39. Association Between Sleep Duration and Diabetes Mellitus: Isfahan Healthy Heart Program, Nigerian Journal of Clinical Practice (2013)
40. Association Between Asthma and Body Mass Index in Children, Iranian Journal of Allergy, Asthma and Immunology (2005)
41. First Report on the Validity of a Continuous Metabolic Syndrome Score As an Indicator for Metabolic Syndrome in a National Sample of Paediatric Population - the Caspian-Iii Study, Endokrynologia Polska (2013)
42. Consanguineous Marriage Among Familial Multiple Sclerosis Subjects: A National Registry-Based Study, Heliyon (2024)
43. Correlation of Circulating Inflammatory Markers, Ghrelin, Adiponectin With Obesity Indices in Subjects With Metabolic Syndrome, Pakistan Journal of Medical Sciences (2013)
44. A Study on Body Mass Index, Blood Pressure, and Red Blood Cell Indices in New Entering Students of the University of Isfahan, International Journal of Preventive Medicine (2011)
45. Association of Retinol-Binding Protein 4 With Metabolic Syndrome in First-Degree Relatives of Type 2 Diabetic Patients, Journal of Research in Medical Sciences (2017)
46. Atherosclerosis and Multiple Sclerosis: An Overview on the Prevalence of Risk Factors, Multiple Sclerosis and Related Disorders (2022)
47. Transcription Factor 7-Like 2 (Tcf7l2) Gene Polymorphism Rs7903146 Is Associated With Lipid Profile and Risk of Cardiovascular Disease Inmetabolic Syndrome Subjects, Journal of Biology and Today's World (2016)
48. Association of Parental Obesity With Cardiometabolic Risk Factors in Their Children: The Caspian-V Study, PLoS ONE (2018)
49. The Association Between Daytime Sleep and General Obesity Risk Differs by Sleep Duration in Iranian Adults, Annals of Human Biology (2023)
50. Prevalence of Sleep Apnea-Related Symptoms in a Persian Population, Sleep and Breathing (2011)