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A New Computer-Aided Diagnosis Tool Based on Deep Learning Methods for Automatic Detection of Retinal Disorders From Oct Images Publisher Pubmed



Alizadeh Eghtedar R1, 4 ; Vard A1, 2 ; Malekahmadi M5, 6 ; Peyman A5, 6
Authors
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Authors Affiliations
  1. 1. Department of Bioelectrics and Biomedical Engineering, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Medical Image & amp
  3. 3. Signal Processing Research Center, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Ophthalmology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Isfahan Eye Research Center, Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Ophthalmology Published:2024


Abstract

Purpose: Early detection of retinal disorders using optical coherence tomography (OCT) images can prevent vision loss. Since manual screening can be time-consuming, tedious, and fallible, we present a reliable computer-aided diagnosis (CAD) software based on deep learning. Also, we made efforts to increase the interpretability of the deep learning methods, overcome their vague and black box nature, and also understand their behavior in the diagnosis. Methods: We propose a novel method to improve the interpretability of the used deep neural network by embedding the rich semantic information of abnormal areas based on the ophthalmologists’ interpretations and medical descriptions in the OCT images. Finally, we trained the classification network on a small subset of the online publicly available University of California San Diego (UCSD) dataset with an overall of 29,800 OCT images. Results: The experimental results on the 1000 test OCT images show that the proposed method achieves the overall precision, accuracy, sensitivity, and f1-score of 97.6%, 97.6%, 97.6%, and 97.59%, respectively. Also, the heat map images provide a clear region of interest which indicates that the interpretability of the proposed method is increased dramatically. Conclusion: The proposed software can help ophthalmologists in providing a second opinion to make a decision, and primitive automated diagnoses of retinal diseases and even it can be used as a screening tool, in eye clinics. Also, the improvement of the interpretability of the proposed method causes to increase in the model generalization, and therefore, it will work properly on a wide range of other OCT datasets. © The Author(s), under exclusive licence to Springer Nature B.V. 2024.
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