Quinazolinone and Quinazoline Derivatives: Recent Structures With Potent Antimicrobial and Cytotoxic Activities



Jafari E^{1, 2} ; Khajouei MR^{2, 3} ; Hassanzadeh F^{1, 2} ; Hakimelahi GH⁴ ; Khodarahmi GA^{1, 2}
Source: Research in Pharmaceutical Sciences Published:2016

Abstract

The heterocyclic compounds have a great importance in medicinal chemistry. One of the most important heterocycles in medicinal chemistry are quinazolines possessing wide spectrum of biological properties like antibacterial, antifungal, anticonvulsant, anti-inflammatory, anti-HIV, anticancer and analgesic activities. This skeleton is an important pharmacophore considered as a privileged structure. This review highlights the recent advances in the synthesis of quinazolines and quinazolinone derivatives with potent antimicrobial and cytotoxic activities.