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Quinazolinone and Quinazoline Derivatives: Recent Structures With Potent Antimicrobial and Cytotoxic Activities



Jafari E1, 2 ; Khajouei MR2, 3 ; Hassanzadeh F1, 2 ; Hakimelahi GH4 ; Khodarahmi GA1, 2
Authors
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Authors Affiliations
  1. 1. Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran
  4. 4. Institute of Chemistry, Academia Sinica, Nankang, Taipei, Taiwan

Source: Research in Pharmaceutical Sciences Published:2016

Abstract

The heterocyclic compounds have a great importance in medicinal chemistry. One of the most important heterocycles in medicinal chemistry are quinazolines possessing wide spectrum of biological properties like antibacterial, antifungal, anticonvulsant, anti-inflammatory, anti-HIV, anticancer and analgesic activities. This skeleton is an important pharmacophore considered as a privileged structure. This review highlights the recent advances in the synthesis of quinazolines and quinazolinone derivatives with potent antimicrobial and cytotoxic activities.
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