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Synthesis and Cytotoxicity Evaluation of Some New 6-Nitro Derivatives of Thiazole-Containing 4-(3H)-Quinazolinone



Hosseinzadeh L1 ; Aliabadi A2 ; Kalantari M3 ; Mostafavi A4 ; Khajouei MR1, 2
Authors
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Authors Affiliations
  1. 1. Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, IR, Iran
  2. 2. Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Science, Kermanshah University of Medical Sciences, Kermanshah, IR, Iran
  3. 3. Stud. Research Committee, School of Pharmacy and Pharmaceutical Science, Kermanshah University of Medical Sciences, Kermanshah, IR, Iran
  4. 4. Department of Pharmaceutics and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Science, Isfahan University of Medical Sciences, IR, Iran

Source: Research in Pharmaceutical Sciences Published:2016

Abstract

Quinazolinones are a group of fused heterocyclic compounds which have valuable biological properties including cytotoxic, antibacterial and antifungal activities. Thiazole group-containing compounds have been also reported to have a wide range of biological activities such as antitumor, anti-inflammatory, analgesic and antibacterial effects. Due to valuable cytotoxic effects of both thiazole groups and quinazoline derivatives, in this study a series of quinazolinone-thiazole hybrids were synthesized and evaluated for their cytotoxic effects on three cell lines including MCF-7, HT-29, and PC-3. Among tested compounds (quinazolinones and three intermediates), k5 and k6 showed highest cytotoxic activities against PC3 cell line. K6 and C were most active compounds against MCF7 and K6 showed best cytotoxicity on HT-29 cell line.
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