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Neuropsychiatric Manifestations of Covid-19 in Hospitalized Pediatrics: A Multicenter Cross-Sectional Study Publisher



Zahed G1 ; Karimzadeh P2 ; Wissow LS3 ; Arman S4 ; Babaee M5 ; Badv RS6 ; Zeinali V7 ; Zarafshan H8 ; Armin S9 ; Nasiri S10 ; Hashemi N11 ; Moayedi A12 ; Amoughin LZ13 ; Ashrafi MR13 Show All Authors
Authors
  1. Zahed G1
  2. Karimzadeh P2
  3. Wissow LS3
  4. Arman S4
  5. Babaee M5
  6. Badv RS6
  7. Zeinali V7
  8. Zarafshan H8
  9. Armin S9
  10. Nasiri S10
  11. Hashemi N11
  12. Moayedi A12
  13. Amoughin LZ13
  14. Ashrafi MR13
  15. Memar EHEM13
  16. Ebrahimi M13
  17. Hosseinzadeh M7
  18. Karimi A7
  19. Fahimzad SA7
  20. Mofradnejad S14
  21. Mirkarimi M14
  22. Mirzadeh M15
  23. Aelami MH11
  24. Tariverdi M16
  25. Jafari F16
  26. Yaghini O17
  27. Pourmoghaddas Z17
  28. Khosravi B18
  29. Mohammadzadeh S18
  30. Soltani J18
  31. Abedini M18
  32. Arabpour M19
  33. Hosseininasab A19
  34. Shahrbabki ME19
  35. Biglari HN19
  36. Behmanesh H20
  37. Sedighi I20
  38. Fayazi A20
  39. Bidabadi E21
  40. Kousha M21
  41. Hashemian H21
  42. Akbarirad F22
  43. Khajeh A22
  44. Soleimani G22
  45. Cheraghali F23
  46. Hosseini SA23
  47. Tabatabaei SR7
  48. Ghanaiee RM7
  49. Alisamir M14
  50. Heidari M13
  51. Asl PK23
  52. Shamsizadeh A14
  53. Heidari S14
  54. Akhondian J11
  55. Vanda NF13
Show Affiliations
Authors Affiliations
  1. 1. Pediatric Neurology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Pediatric Neurology Department, Pediatric Neurology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Division of Child and Adolescent Psychiatry, School of Medicine, University of Washington, Seattle, United States
  4. 4. Behavioral Sciences Research Center, Department of Psychiatry, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Physical Medicine and Rehabilitation Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Children’s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Department of Autism & Neurodevelopmental Disorders, Psychiatry and Psychology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Pediatric Infectious Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  10. 10. Children’s Medical Center of Abuzar, Jundishapur University of Medical Sciences, Ahvaz, Iran
  11. 11. Mashhad University of Medical Sciences, Mashhad, Iran
  12. 12. Clinical Research Development Center of Children’s Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
  13. 13. Tehran University of Medical sciences, Tehran, Iran
  14. 14. Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  15. 15. Islamic Azad University of Mashhad, Mashhad, Iran
  16. 16. Hormozgan University of Medical Sciences, Bandar Abbas, Iran
  17. 17. Isfahan University of Medical Sciences, Isfahan, Iran
  18. 18. Kurdistan University of Medical Sciences, Sanandaj, Iran
  19. 19. Kerman University of Medical Sciences, Kerman, Iran
  20. 20. Hamadan University of Medical Sciences, Hamadan, Iran
  21. 21. Guilan University of Medical Sciences, Rasht, Iran
  22. 22. Zahedan University of Medical Sciences, Zahedan, Iran
  23. 23. Golestan University of Medical Sciences, Gorgan, Iran

Source: Archives of Pediatric Infectious Diseases Published:2023


Abstract

Background: The large proportion of coronavirus disease 2019 (COVID-19) patients has been associated with a large number of neu-ropsychiatric manifestations. Despite the high prevalence of COVID-19, few studies have examined such manifestations, especially in children and adolescents. Objectives: This study investigated neuropsychiatric manifestations in hospitalized children and adolescents admitted for COVID-19 infection in Iran. Methods: This prospective observational study included admitted children and adolescents (4-18 years old) diagnosed with COVID-19 infection, pediatric neurologists, child and adolescent psychiatrists, and infectious disease specialists, and assessed 375 infected patients during August and December 2021. Results: Of the 375 patients, 176 (47%) were female, with a mean age of 9.0 ± 3.39 years. Psychiatric and neurological manifestations were reported in 58 (15.5%) and 58 (15.5%) patients, respectively. The most prevalent psychiatric disorders were separation anxiety disorder (SAD) (5.1%), major depressive disorder (MDD) (3.5%), generalized anxiety disorder (GAD) (2.7%), insomnia (2.4%), and op-positional defiant disorder (ODD) (2.4%). Regarding neurological complications, seizures were the most prevalent (13.1%), followed by encephalitis (1.9%), transverse myelitis (0.3%), acute ischemic stroke (0.3%), and Guillain-Barre syndrome (0.3%). There was no significant relationship between the duration of COVID-19 infection (P = 0.54) and ICU admission (P = 0.44) with the emergence of psychiatric symptoms. Conclusions: The most prevalent neurologic and psychiatric complications among children and adolescents with COVID-19 infection were seizures and the symptoms of anxiety/mood disorders, respectively. © 2023, Author(s).
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