Evaluating Final Pathology Results in Patients Operated for Intraductal Papilloma Publisher



Samani RE¹ ; Dolatshahi K² ; Dolatshahi K² ; Safaee M¹ Show Affiliations
Source: Immunopathologia Persa Published:2025

Abstract

Introduction: Intraductal papilloma is a breast lesion caused by abnormal epithelial proliferation of ducts. Objectives: The aim of this study was to evaluate the final pathology reports of intraductal papilloma. Patients and Methods: This cross-sectional study was conducted in Isfahan, containing 101 cases initially diagnosed with intraductal papilloma. We reviewed the medical documents and pathology reports of all cases with the following information of age, consumption of oral contraceptive pills, hormone replacement therapy, age of menarche, age of menopause and familial history of breast, ovarian, or endometrial cancers, and the pathology reports from tissue biopsy. The statistical analysis utilized chi-square test for qualitative variables and analysis of variance for quantitative variables. Results: The frequency distribution of pathology results showed that in 37.4% (n = 35) of cases, intra-ductal papilloma were observed, and in 30.7% (n = 31) of them, benign lesions were reported. Additionally, 29.7% (n = 30) had pre-malignant lesions, and 5% (n = 5) had malignant lesions. Among the factors, only age was related to the type of lesion, with the mean age of people with pre-malignant or malignant lesions being significantly higher than those with benign lesions (P = 0.014). Conclusion: Complete excision and pathological evaluation of intraductal papilloma could reveal significant findings. Special attention should be given to older patients with intraductal papilloma. © 2025 The Author(s)