Ultra-Processed Foods and Mortality: Analysis From the Prospective Urban and Rural Epidemiology Study

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Ultra-Processed Foods and Mortality: Analysis From the Prospective Urban and Rural Epidemiology Study Publisher Pubmed

Dehghan M¹ ; Mente A¹ ; Rangarajan S¹ ; Mohan V² ; Swaminathan S³ ; Avezum A⁴ ; Lear SA⁵ ; Rosengren A⁶ ; Poirier P⁷ ; Lanas F⁸ ; Lopezjaramillo P⁹ ; Soman B¹⁰ ; Wang C¹¹ ; Orlandini A¹² Show All Authors

Dehghan M¹
Mente A¹
Rangarajan S¹
Mohan V²
Swaminathan S³
Avezum A⁴
Lear SA⁵
Rosengren A⁶
Poirier P⁷
Lanas F⁸
Lopezjaramillo P⁹
Soman B¹⁰
Wang C¹¹
Orlandini A¹²
Mohammadifard N¹³
Alhabib KF¹⁴
Chifamba J¹⁵
Yusufali AH¹⁶
Iqbal R¹⁷
Khatib R¹⁸
Yeates K¹⁹
Puoane T²⁰
Altuntas Y²¹
Co HU²²
Li S¹¹
Liu W¹¹
Zatonska K²³
Yusuf R²⁴
Ismail N²⁵
Miller V¹
Yusuf S¹

Show Affiliations

1. Population Health Research Institute, McMaster University, Hamilton, ON, Canada
2. Dr. Mohan's Diabetes Specialities Centre, Chennai, India
3. St John's Research Institute, St John's National Academy of Health Sciences, Sarjapur Road, Koramangala, Karnataka, Bangalore, India
4. International Research Center, Hospital Alemao Oswaldo Cruz, Sao Paulo, Brazil
5. Faculty of Health Sciences, Simon Fraser University c/o Healthy Heart Program, St. Paul's Hospital, Vancouver, BC, Canada
6. Sahlgrenska Academy, University of Gothenburg and Sahlgrenska University Hospital, VGR Region, Sweden
7. Heart and Lung Institute, Laval University, Quebec City, QC, Canada
8. University of La Frontera, Temuco, Chile
9. Masira Research Institute, Medical School, Universidad de Santander, Bucaramanga, Colombia
10. Health Action by People, Kerala, Thiruvananthapuram, India
11. Medical Research and Biometrics Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
12. Clinical Studies Latin America, Rosario, Santa Fe, Argentina
13. Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
14. Department of Cardiac Sciences, King Fahad Cardiac Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia
15. University of Zimbabwe, Faculty of Medicine and Health Sciences, Unit of Physiology, Harare, Zimbabwe
16. Hatta Hospital, Dubai Medical College, Dubai Health Authority, Dubai, United Arab Emirates
17. Department of Community Health Sciences and Medicine, Aga Khan University, Pakistan
18. Institute for Community and Public Health, Birzeit University, Palestine & Advocate Research Institute, Advocate Health Care, Birzeit, IL, United States
19. Department of Medicine, Queen's University, Kingston, Canada
20. School of Public Health, University of the Western Cape, Bellville, South Africa
21. University of Health Sciences Turkey, Faculty of Medicine, Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Clinic of Endocrinology and Metabolism, Sisli, Istanbul, Turkey
22. University of the Philippines College of Medicine, Manila, Philippines
23. Social Medicine Department of Wroclaw Medical University, Poland
24. Independent University, Dhaka, Bangladesh
25. Department of Community Health, Faculty of Medicine, University Kebangsaan, Kuala Lumpur, Malaysia

Source: American Journal of Clinical Nutrition Published:2023

Abstract

Background: Higher intake of ultra-processed foods (UPFs) has been associated with increased risk of CVD and mortality in observational studies from Western countries but data from non-Western countries are limited. Objectives: We aimed to assess the association between consumption of UPFs and risk of mortality and major CVD in a cohort from multiple world regions. Design: This analysis includes 138,076 participants without a history of CVD between the ages of 35 and 70 y living on 5 continents, with a median follow-up of 10.2 y. We used country-specific validated food-frequency questionnaires to determine individuals’ food intake. We classified foods and beverages based on the NOVA classification into UPFs. The primary outcome was total mortality (CV and non-CV mortality) and secondary outcomes were incident major cardiovascular events. We calculated hazard ratios using multivariable Cox frailty models and evaluated the association of UPFs with total mortality, CV mortality, non-CV mortality, and major CVD events. Results: In this study, 9227 deaths and 7934 major cardiovascular events were recorded during the follow-up period. We found a diet high in UPFs (≥2 servings/d compared with 0 intake) was associated with higher risk of mortality (HR: 1.28; 95% CI: 1.15, 1.42; P-trend < 0.001), CV mortality (HR: 1.17; 95% CI: 0.98, 1.41; P-trend = 0.04), and non-CV mortality (HR: 1.32; 95% CI 1.17, 1.50; P-trend < 0.001). We did not find a significant association between UPF intake and risk of major CVD. Conclusions: A diet with a high intake of UPFs was associated with a higher risk of mortality in a diverse multinational study. Globally, limiting the consumption of UPFs should be encouraged. © 2022 American Society for Nutrition

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Style	Citing Format
MLA	Dehghan M, et al.. "Ultra-Processed Foods and Mortality: Analysis From the Prospective Urban and Rural Epidemiology Study." American Journal of Clinical Nutrition, vol. 117, no. 1, 2023, pp. 55-63.
APA	Dehghan M, Mente A, Rangarajan S, Mohan V, Swaminathan S, Avezum A, Lear SA, Rosengren A, Poirier P, Lanas F, Lopezjaramillo P, Soman B, Wang C, Orlandini A, Mohammadifard N, Alhabib KF, Chifamba J, Yusufali AH, Iqbal R, ... Yusuf S (2023). Ultra-Processed Foods and Mortality: Analysis From the Prospective Urban and Rural Epidemiology Study. American Journal of Clinical Nutrition, 117(1), 55-63.
Chicago	Dehghan M, Mente A, Rangarajan S, Mohan V, Swaminathan S, Avezum A, Lear SA, et al.. "Ultra-Processed Foods and Mortality: Analysis From the Prospective Urban and Rural Epidemiology Study." American Journal of Clinical Nutrition 117, no. 1 (2023): 55-63.
Harvard	Dehghan M et al. (2023) 'Ultra-Processed Foods and Mortality: Analysis From the Prospective Urban and Rural Epidemiology Study', American Journal of Clinical Nutrition, 117(1), pp. 55-63.
Vancouver	Dehghan M, Mente A, Rangarajan S, Mohan V, Swaminathan S, Avezum A, et al.. Ultra-Processed Foods and Mortality: Analysis From the Prospective Urban and Rural Epidemiology Study. American Journal of Clinical Nutrition. 2023;117(1):55-63.
BibTex	@article{ author = {Dehghan M and Mente A and Rangarajan S and Mohan V and Swaminathan S and Avezum A and Lear SA and Rosengren A and Poirier P and Lanas F and Lopezjaramillo P and Soman B and Wang C and Orlandini A and Mohammadifard N and Alhabib KF and Chifamba J and Yusufali AH and Iqbal R and Khatib R and Yeates K and Puoane T and Altuntas Y and Co HU and Li S and Liu W and Zatonska K and Yusuf R and Ismail N and Miller V and Yusuf S}, title = {Ultra-Processed Foods and Mortality: Analysis From the Prospective Urban and Rural Epidemiology Study}, journal = {American Journal of Clinical Nutrition}, volume = {117}, number = {1}, pages = {55-63}, year = {2023} }
RIS	TY - JOUR AU - Dehghan M AU - Mente A AU - Rangarajan S AU - Mohan V AU - Swaminathan S AU - Avezum A AU - Lear SA AU - Rosengren A AU - Poirier P AU - Lanas F AU - Lopezjaramillo P AU - Soman B AU - Wang C AU - Orlandini A AU - Mohammadifard N AU - Alhabib KF AU - Chifamba J AU - Yusufali AH AU - Iqbal R AU - Khatib R AU - Yeates K AU - Puoane T AU - Altuntas Y AU - Co HU AU - Li S AU - Liu W AU - Zatonska K AU - Yusuf R AU - Ismail N AU - Miller V AU - Yusuf S TI - Ultra-Processed Foods and Mortality: Analysis From the Prospective Urban and Rural Epidemiology Study JO - American Journal of Clinical Nutrition VL - 117 IS - 1 SP - 55 EP - 63 PY - 2023 ER -

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