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Ultra-Processed Foods and Mortality: Analysis From the Prospective Urban and Rural Epidemiology Study Publisher Pubmed

Summary: Eating lots of ultra-processed foods could boost mortality risks, revealing a global study. #Health #Nutrition

Dehghan M1 ; Mente A1 ; Rangarajan S1 ; Mohan V2 ; Swaminathan S3 ; Avezum A4 ; Lear SA5 ; Rosengren A6 ; Poirier P7 ; Lanas F8 ; Lopezjaramillo P9 ; Soman B10 ; Wang C11 ; Orlandini A12 Show All Authors
Authors
  1. Dehghan M1
  2. Mente A1
  3. Rangarajan S1
  4. Mohan V2
  5. Swaminathan S3
  6. Avezum A4
  7. Lear SA5
  8. Rosengren A6
  9. Poirier P7
  10. Lanas F8
  11. Lopezjaramillo P9
  12. Soman B10
  13. Wang C11
  14. Orlandini A12
  15. Mohammadifard N13
  16. Alhabib KF14
  17. Chifamba J15
  18. Yusufali AH16
  19. Iqbal R17
  20. Khatib R18
  21. Yeates K19
  22. Puoane T20
  23. Altuntas Y21
  24. Co HU22
  25. Li S11
  26. Liu W11
  27. Zatonska K23
  28. Yusuf R24
  29. Ismail N25
  30. Miller V1
  31. Yusuf S1

Source: American Journal of Clinical Nutrition Published:2023


Abstract

Background: Higher intake of ultra-processed foods (UPFs) has been associated with increased risk of CVD and mortality in observational studies from Western countries but data from non-Western countries are limited. Objectives: We aimed to assess the association between consumption of UPFs and risk of mortality and major CVD in a cohort from multiple world regions. Design: This analysis includes 138,076 participants without a history of CVD between the ages of 35 and 70 y living on 5 continents, with a median follow-up of 10.2 y. We used country-specific validated food-frequency questionnaires to determine individuals’ food intake. We classified foods and beverages based on the NOVA classification into UPFs. The primary outcome was total mortality (CV and non-CV mortality) and secondary outcomes were incident major cardiovascular events. We calculated hazard ratios using multivariable Cox frailty models and evaluated the association of UPFs with total mortality, CV mortality, non-CV mortality, and major CVD events. Results: In this study, 9227 deaths and 7934 major cardiovascular events were recorded during the follow-up period. We found a diet high in UPFs (≥2 servings/d compared with 0 intake) was associated with higher risk of mortality (HR: 1.28; 95% CI: 1.15, 1.42; P-trend < 0.001), CV mortality (HR: 1.17; 95% CI: 0.98, 1.41; P-trend = 0.04), and non-CV mortality (HR: 1.32; 95% CI 1.17, 1.50; P-trend < 0.001). We did not find a significant association between UPF intake and risk of major CVD. Conclusions: A diet with a high intake of UPFs was associated with a higher risk of mortality in a diverse multinational study. Globally, limiting the consumption of UPFs should be encouraged. © 2022 American Society for Nutrition
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