Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Ultra-Processed Food Consumption and Cardiovascular Events Rate: An Analysis From Isfahan Cohort Study (Ics) Publisher Pubmed



Kermanialghoraishi M1 ; Behrouzi A1 ; Hassannejad R2 ; Sarrafzadegan N2 ; Nouri F3 ; Boshatam M4 ; Roohafza H5 ; Haghighatdoost F2 ; Sadeghi M6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Interventional Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Pediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Heart Failure Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Hypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Nutrition, Metabolism and Cardiovascular Diseases Published:2024


Abstract

Background and aims: The contribution of ultra-processed foods (UPFs) to daily energy intake and, therefore, their health effects may vary between countries. We aimed to investigate the association between UPFs and the incidence risk of cardiovascular events (CVEs) and cardiovascular mortality in the Isfahan cohort study. Methods and results: In 2001, 6504 participants aged ≥35 years were enrolled and followed until 2017. Dietary intake was assessed using a validated food frequency questionnaire, and the NOVA system was applied for UPF classification. Any new case of CVE, including fatal and non-fatal myocardial infarction (MI) or stroke, unstable angina (UA), and CVD death, was recorded. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated through Cox proportional hazards regression models. A total number of 819 CVE, 164 MI, 348 UA, 172 strokes, and 181 cardiovascular deaths were recorded during 61352.5 person-years of follow-up. The median (IQR) of UPF consumption was 2.47 (1.00–5.23) times/week. In the fully adjusted model, individuals in the fourth quartile of UPFs had no higher risk for incident MI and UA (HR = 1.12, 95% CI: 0.87, 1.46; P for trend = 0.364), stroke (HR = 0.93, 95% CI: 0.58, 1.46; P for trend = 0.601), cardiovascular mortality (HR = 0.95, 95% CI: 0.61, 1.47; P for trend = 0.596), and CVE (HR = 1.08, 95% CI: 0.88,1.34; P for trend = 0.515) in comparison with those in the first quartile. Conclusion: This mid-term prospective cohort study provides no evidence for a significant association between UPF and CVE risk. Longer studies are required to confirm this association. © 2024 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University
Related Docs
View other Related Docs
1. Ultra-Processed Foods and Mortality: Analysis From the Prospective Urban and Rural Epidemiology Study, American Journal of Clinical Nutrition (2023)
2. Dietary Patterns and Mortality From Cardiovascular Disease: Isfahan Cohort Study, European Journal of Clinical Nutrition (2017)
3. Longitudinal Association of Dietary Fat Intake With Cardiovascular Events in a Prospective Cohort Study in Eastern Mediterranean Region, International Journal of Food Sciences and Nutrition (2021)
4. Longitudinal Association of Dietary Habits and the Risk of Cardiovascular Disease Among Iranian Population Between 2001 and 2013: The Isfahan Cohort Study, Scientific Reports (2023)
5. Egg Consumption and Risk of Cardiovascular Events Among Iranians: Results From Isfahan Cohort Study (Ics), European Journal of Clinical Nutrition (2022)
6. The Relationship Between Ultra Processed Food Consumption and Premature Coronary Artery Disease: Iran Premature Coronary Artery Disease Study (Ipad), Frontiers in Nutrition (2023)
7. Association Between Ultra-Processed Foods Consumption and Micronutrient Intake and Diet Quality in Iranian Adults: A Multicentric Study, Public Health Nutrition (2023)
8. Association of Ultra-Processed Food Consumption With Cardiovascular Risk Factors Among Patients With Type-2 Diabetes Mellitus, Nutrition and Diabetes (2024)
Experts (# of related papers)
View all Related Experts
Nizal Sarrafzadegan (140)
Noushin Mohammadifard (102)
Other Related Docs
9. Whole Milk Consumption and Risk of Cardiovascular Disease and Mortality: Isfahan Cohort Study, European Journal of Nutrition (2019)
10. Ultra‐Processed Food Consumption and Adult Mortality Risk: A Systematic Review and Dose–Response Meta‐Analysis of 207,291 Participants, Nutrients (2022)
11. Longitudinal Association of Nut Consumption and the Risk of Cardiovascular Events: A Prospective Cohort Study in the Eastern Mediterranean Region, Frontiers in Nutrition (2021)
12. Differences in All-Cause Mortality Risk Associated With Animal and Plant Dietary Protein Sources Consumption, Scientific Reports (2023)
13. Long-Term Association of Nut Consumption and Cardiometabolic Risk Factors, Nutrition, Metabolism and Cardiovascular Diseases (2019)
14. Long-Term Exposure to Pm2.5 and Cardiovascular Disease Incidence and Mortality in an Eastern Mediterranean Country: Findings Based on a 15-Year Cohort Study, Environmental Health: A Global Access Science Source (2021)
15. Egg Consumption and Risk of Cardiovascular Disease: A Persian Cohort-Based Study, BMC Cardiovascular Disorders (2023)
16. Lipid Accumulation Product and Visceral Adiposity Index for Incidence of Cardiovascular Diseases and Mortality; Results From 13 Years Follow-Up in Isfahan Cohort Study, Obesity Science and Practice (2024)
17. The Longitudinal Association Between Soybean and Non-Soybean Legumes Intakes and Risk of Cardiovascular Disease: Isfahan Cohort Study, British Food Journal (2021)
18. Long-Term Association of Red Meat Consumption and Lipid Profile: A 13-Year Prospective Population-Based Cohort Study, Nutrition (2021)
19. Red and Processed Meat Consumption and Risk of Incident Cardiovascular Disease and Mortality: Isfahan Cohort Study, International Journal of Food Sciences and Nutrition (2022)
20. A Healthy Diet, Physical Activity, or Either in Relation to Cardiovascular and All-Cause Mortality: A Prospective Cohort Study, Nutrition (2023)
21. The Long-Term Association of Different Dietary Protein Sources With Metabolic Syndrome, Scientific Reports (2021)
22. Ultra-Processed Food Intake and Risk of Colorectal Cancer: A Matched Case-Control Study, Nutrition and Cancer (2023)
23. Population Food Intake Clusters and Cardiovascular Disease Incidence: A Bayesian Quantifying of a Prospective Population-Based Cohort Study in a Low and Middle-Income Country, Frontiers in Nutrition (2023)
24. Intake of Legumes and the Risk of Cardiovascular Disease: Frailty Modeling of a Prospective Cohort Study in the Iranian Middle-Aged and Older Population, European Journal of Clinical Nutrition (2016)
25. Occupational Categories and Cardiovascular Diseases Incidences: A Cohort Study in Iranian Population, Journal of Preventive Medicine and Hygiene (2020)
26. The Impact of Health-Related Quality of Life on the Incidence of Ischaemic Heart Disease and Stroke; a Cohort Study in an Iranian Population, Acta Cardiologica (2016)
27. Association of Triglyceride Glucose Index With Cardiovascular Events: Insights From the Isfahan Cohort Study (Ics), European Journal of Medical Research (2024)
28. The Relationship Between Ultraprocessed Food Consumption and Obesity Indicators in Iranian Adults, Nutrition, Metabolism and Cardiovascular Diseases (2022)
29. Dairy Products and Metabolic Syndrome Among Iranian Adult Population: Isfahan Healthy Heart Program, International Dairy Journal (2020)
30. Impact of Diabesity Phenotype on Cardiovascular Diseases, Major Cardiovascular Events and All-Cause Mortality, Scientific Reports (2023)
31. Dietary Patterns in Relation to Lipid Profiles Among Iranian Adults, Journal of Cardiovascular and Thoracic Research (2019)
32. High-Sensitivity C-Reactive Protein and Low-Density Lipoprotein Cholesterol Association With Incident of Cardiovascular Events: Isfahan Cohort Study, BMC Cardiovascular Disorders (2022)
33. Tea and Coffee Consumption and the 15-Year Risk of Cardiovascular Events: The Isfahan Cohort Study (Ics), Nutrition Journal (2025)
34. Impact of Metabolic Syndrome on Ischemic Heart Disease - a Prospective Cohort Study in an Iranian Adult Population: Isfahan Cohort Study, Nutrition, Metabolism and Cardiovascular Diseases (2012)
35. Methods of Sampling and Sample Size Determination of a Comprehensive Integrated Community-Based Interventional Trial: Isfahan Healthy Heart Program, ARYA Atherosclerosis (2018)
36. Fruit, Vegetable, and Legume Intake, and Cardiovascular Disease and Deaths in 18 Countries (Pure): A Prospective Cohort Study, The Lancet (2017)
37. Associations of Unprocessed and Processed Meat Intake With Mortality and Cardiovascular Disease in 21 Countries [Prospective Urban Rural Epidemiology (Pure) Study]: A Prospective Cohort Study, American Journal of Clinical Nutrition (2021)
38. Comparing the Risk of Cardiovascular Diseases and All-Cause Mortality in Four Lifestyles With a Combination of High/Low Physical Activity and Healthy/Unhealthy Diet: A Prospective Cohort Study, International Journal of Behavioral Nutrition and Physical Activity (2022)
39. Association Between Ultra-Processed Foods Intake With Lipid Profile: A Cross-Sectional Study, Scientific Reports (2023)
40. Exploring the Association Between Ultra-Processed Foods and Copd: A Case-Control Study, BMC Pulmonary Medicine (2024)
41. Longitudinal Association of Metabolic Syndrome and Dietary Patterns: A 13-Year Prospective Population-Based Cohort Study, Nutrition, Metabolism and Cardiovascular Diseases (2018)
42. Pathways Leading to Prevention of Fatal and Non-Fatal Cardiovascular Disease: An Interaction Model on 15 Years Population-Based Cohort Study, Lipids in Health and Disease (2020)
43. Comparing the Association of Novel Anthropometric and Atherogenicity Indices With All-Cause, Cardiovascular and Non-Cardiovascular Mortality in a General Population of Iranian Adults, American Journal of Preventive Cardiology (2025)
44. The Association of Food Quality Score and Cardiovascular Diseases Risk Factors Among Women: A Cross-Sectional Study, Journal of Cardiovascular and Thoracic Research (2019)
45. Association of Glycaemic Index and Glycaemic Load With Metabolic Syndrome in an Iranian Adult Population: Isfahan Healthy Heart Program, Nutrition and Dietetics (2017)
46. Associations of Fish Consumption With Risk of Cardiovascular Disease and Mortality Among Individuals With or Without Vascular Disease From 58 Countries, JAMA Internal Medicine (2021)
47. Association of Dairy Intake With Cardiovascular Disease and Mortality in 21 Countries From Five Continents (Pure): A Prospective Cohort Study, The Lancet (2018)
48. Adherence to Alternative Healthy Eating Index (Ahei-2010) Is Not Associated With Risk of Stroke in Iranian Adults: A Case-Control Study, International Journal for Vitamin and Nutrition Research (2021)
49. Longitudinal Association of Dietary Carbohydrate and the Risk Cardiovascular Disease: A Dose-Response Meta-Analysis, Critical Reviews in Food Science and Nutrition (2022)
50. Dietary Advanced Glycation End Products and Risk of Overall and Cause-Specific Mortality: Results From the Golestan Cohort Study, International Journal of Environmental Research and Public Health (2023)