Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effect of L-Arginine and L-Name on Coronary Angiogenesis in Male Diabetic Rats



Khazaei M1 ; Moshayedi MA2 ; Teimouri Jervekani M2 ; Aghili S2 ; Montazeri S2 ; Mehdipour Dastjerdi R2 ; Hashemzehi F2 ; Hashemi Jazi H2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Research in Medical Sciences Published:2012

Abstract

BACKGROUND: Diabetes is associated with several vascular abnormalities due to abnormal angiogenesis. Vascular endothelial growth factor (VEGF) and nitric oxide are among the most important angiogenic factors. The aim of this study was to evaluate the effect of L-arginine (L-Arg) and L-NG-Nitroarginine Methyl Ester (L-NAME) on coronary angiogenesis in male diabetic rats. METHODS: 24 male rats were randomly divided into four groups: (1) control, (2) diabetic, (3) diabetic + L-Arg (50mg/kg/day, ip) and (4) diabetic + L-NAME (10mg/kg/day, ip). After three weeks, blood samples were taken and the apex of the hearts was stained for immunohistochemistry. RESULTS: Coronary angiogenesis expressed as capillary density/mm2 was lower in diabetic group compared to the control group (p < 0.05). L-Arg significantly improved capillary density in myocardial tissue in diabetic animals (p < 0.05); however, L-NAME did not alter it (p > 0.05). CONCLUSIONS: It seems that L-Arg improves coronary angiogenesis in type I diabetic animals through changes of serum angiogenic factors. More studies are needed to clarify the effect of nitric oxide agonists in different experimental models of angiogenesis.
Related Docs
View other Related Docs
1. The Effects of L-Arginine (The Precursor of Nitric Oxide) and L-Name (Nitric Oxide Synthase Inhibitor) on Coronary Angiogenesis in Normal Rats, Journal of Isfahan Medical School (2011)
2. Effects of Diabetes on Myocardial Capillary Density and Serum Angiogenesis Biomarkers in Male Rats, Clinics (2011)
3. Limbs’ Postischemic Revascularization Is Not Improved by Losartan Treatment in Diabetic Rats, Endocrine Regulations (2014)
4. Restoration of Angiogenesis by Enalapril in Diabetic Hindlimb Ischemc Rats, Biomedical Papers (2011)
5. Pan-Ppar Agonist, Bezafibrate, Restores Angiogenesis in Hindlimb Ischemia in Normal and Diabetic Rats, International Journal of Peptides (2012)
6. Role of Gw0742 a Pparβ/Δ Agonist on Coronary Angiogenesis in Control and Diabetic Rats, Journal of Isfahan Medical School (2011)
7. Rosiglitazone Enhances Neovascularization in Diabetic Rat Ischemic Hindlimb Model, Biomedical Papers (2012)
8. Myocardial Capillary Density in Normal and Diabetic Male Rats: Effect of Bezafibrate, Research in Pharmaceutical Sciences (2013)
Experts (# of related papers)
View all Related Experts
Shaghayegh Haghjooy Javanmard (16)
Mehdi Nematbakhsh (12)
Other Related Docs
9. Effects of Dapt on Serum Vascular Endothelial Growth Factor and Its Soluble Receptor in Obese Balb/C Mice, Journal of Isfahan Medical School (2013)
10. Angiogenesis in Health and Disease: Role of Vascular Endothelial Growth Factor (Vegf), Journal of Isfahan Medical School (2011)
11. Effects of Losartan on Capillary Density in Cardiac Muscles of Diabetic Rats, Journal of Isfahan Medical School (2012)
12. Effects of Losartan on Capillary Density in Cardiac Muscles of Diabetic Rats, Journal of Isfahan Medical School (2012)
13. Role of Peroxisome Proliferator-Activated Receptor Β Agonist on Angiogenesis in Hindlimb Ischemic Diabetic Rats, Journal of Diabetes and its Complications (2012)
14. Effect of Rosiglitazone on Coronary Angiogenesis in Diabetic and Control Rats, Journal of Isfahan Medical School (2011)
15. Fenofibrate, a Peroxisome Proliferator-Activated Receptor Alpha, Improves Myocardial Capillary Density in Diabetic Rats., JPMA. The Journal of the Pakistan Medical Association (2012)
16. Inducible Nitric Oxide Synthase Modulates Angiogenesis in Ischemic Hindlimb of Rat, Biomedical Papers (2009)
17. Imbalance of Angiogenesis in Diabetic Complications: The Mechanisms, International Journal of Preventive Medicine (2012)
18. Changes of Plasma Angiogenic Factors During Chronic Resistance Exercise in Type I Diabetic Rats, Pakistan Journal of Medical Sciences (2012)
19. Hyperinsulinemia May Have a Protective Role in the Early Stages of Atherosclerosis in Rabbit Model of Hypercholesterolemia, Journal of Diabetes and Metabolic Disorders (2012)
20. The Sesame Lignan Sesamin Attenuates Vascular Permeability in Rats With Streptozotocin-Induced Diabetes: Involvement of Oxidative Stress, International Journal of Endocrinology and Metabolism (2011)
21. Pathophysiological Correlation of Arginase-1 in Development of Type 2 Diabetes From Obesity in Adolescents, Biochimica et Biophysica Acta - General Subjects (2023)
22. Low Dose of L-Arginine Does Not Change Endothelial Permeability of Aorta and Coronary Arteries in Rat, Pakistan Journal of Nutrition (2008)
23. Effect of Angiotensin Receptor Inhibitors on Endothelial Dysfunction Indices in Patients With Diabetic Nephropathy, Journal of Isfahan Medical School (2011)
24. Protective and Curative Effects of Unconjugated Bilirubin on Gene Expression of Lox-1 and Inos in the Heart of Rats Receiving High-Fat Diet and Low Dose Streptozotocin: A Histomorphometric Approach, Journal of Inflammation (United Kingdom) (2024)
25. The Prevention of Endothelial Dysfunction Through Endothelial Cell Apoptosis Inhibition in a Hypercholesterolemic Rabbit Model: The Effect of L-Arginine Supplementation, Lipids in Health and Disease (2008)
26. The Effect of Maintenance and Reversal of Doca-Salt Hypertension on Extravasation of Macromolecules and Serum Nitric Oxide Concentration in Male Rats, Pathophysiology (2011)
27. Role of Fenofibrate in Restoring Angiogenesis in Diabetic and Control Hind Limb Ischemic Rats, General Physiology and Biophysics (2012)
28. L-Arginine Supplementation Enhances Enos Expression in Experimental Model of Hypercholesterolemic Rabbits Aorta, Pathophysiology (2009)
29. Evaluation of Vascular Endothelial Growth Factor a and Leukemia Inhibitory Factor Expressions at the Time of Implantation in Diabetic Rats Following Treatment With Metformin and Pioglitazone, International Journal of Reproductive BioMedicine (2020)
30. Systemic Administration of Ghrelin Did Not Restore Angiogenesis in Hindlimb Ischemia in Control and Diet-Induced Obese Mice, Bratislava Medical Journal (2015)
31. Oestrogen Promotes Coronary Angiogenesis Even Under Normoxic Conditions, Basic and Clinical Pharmacology and Toxicology (2008)
32. The Effect of L-Arginine on Serum Lipids and Nitrite Levels, and the Number of Apoptotic Cells, Inos and Enos Expressions of Aorta After the Formation of Fatty Streaks in Rabbit, Journal of Applied Biomedicine (2008)
33. Effect of Peroxisome Proliferator-Activated Receptors on Cardiac Remodeling in Normal and Diabetic Rats, Journal of Isfahan Medical School (2014)
34. The Effect of Pramlintide, an Antidiabetic Amylin Analogue, on Angiogenesis-Related Markers in Vitro, Research in Pharmaceutical Sciences (2020)
35. Effect of Chronic L-Arginine Supplementation on Aortic Fatty Streak Formation and Serum Nitric Oxide Concentration in Normal and High-Cholesterol Fed Rabbits, Acta Physiologica Hungarica (2012)
36. The Effect of Captopril on Impaired Wound Healing in Experimental Diabetes, International Journal of Endocrinology (2012)
37. Angiotensin 1-7 Receptor and Angiotensin Ii Receptor 2 Blockades Prevent the Increased Serum and Kidney Nitric Oxide Levels in Response to Angiotensin Ii Administration: Gender-Related Difference, International Journal of Preventive Medicine (2013)
38. Coronary Angiogenesis During Experimental Hypertension: Is It Reversible?, Journal of Research in Medical Sciences (2011)
39. Early Prevention by L-Arginine Attenuates Coronary Atherosclerosis in a Model of Hypercholesterolemic Animals; No Positive Results for Treatment, Nutrition and Metabolism (2009)
40. Ghrelin Does Not Modulate Angiogenesis in Matrigel Plug in Normal and Diet-Induced Obese Mice, Journal of Research in Medical Sciences (2013)
41. Systemic Ghrelin Administration Alters Serum Biomarkers of Angiogenesis in Diet-Induced Obese Mice, International Journal of Peptides (2013)
42. The Effects of Resistance Training on Plasma Angiogenic Factors in Normal Rats, Journal of Isfahan Medical School (2012)
43. Effect of Moderate-Intensity Exercise on Plasma C-Reactive Protein and Aortic Endothelial Function in Type 2 Diabetic Mice, Mediators of Inflammation (2010)
44. The Effects of Blocking Angiotensin Receptors on Early Stages of Diabetic Nephropathy, International Journal of Preventive Medicine (2012)
45. The Effect of Hypercholesterolemia on Serum Vascular Endothelial Growth Factor and Nitrite Concentrations in Early Stage of Atherosclerosis in Rabbits, Pakistan Journal of Nutrition (2009)
46. A Review on Angiogenesis and Its Assays, Iranian Journal of Basic Medical Sciences (2012)
47. L-Arginine Supplementation Influenced Nitrite But Not Nitrate and Total Nitrite in Rabbit Model of Hypercholesterolemia, Iranian Biomedical Journal (2008)
48. The Effect of Estrogen on Endothelial Permeability of Aorta and the Level of Serum Nitrite Concentration in Cholesterol-Fed Ovariectomized Rabbit, Iranian Biomedical Journal (2002)