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Effect of Rosiglitazone on Coronary Angiogenesis in Diabetic and Control Rats



Salehi E1 ; Khazaei M1 ; Rashidi B2 ; Javanmard SH1
Authors
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Authors Affiliations
  1. 1. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Anatomy, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2011

Abstract

Background: Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of nuclear receptor superfamily, consisting of three subtypes: PPARα, γ, β/δ. Clinical evidence suggests that PPARs may be involved in regulating angiogenesis. In this study, we examined the hypothesis that whether activation of PPARγ by Rosiglitazone, a PPARγ agonist, can alter coronary angiogenesis in diabetic and control rats. Methods: Twenty four male rats were randomly divided into four groups as follows: group 1: control rats received vehicle; group 2: control rats received Rosiglitazone (8mg/kg/day) by gavage every day; group 3: diabetic rats received vehicle; group 4: diabetic rats received Rosiglitazone (8mg/kg/day) by gavage everyday. All rats were sacrified after 21 days and their hearts muscles were harvested for immonohistochemistry. Finding: The mean capillary density in control rats was higher than diabetic rats (P = 0.08). Rosiglitazone treatment could not change capillary density of the heart in diabetic rats (121.71 ± 13.32 versus 136.62 ± 7.02/mm2) and nondiabetic rats (153.78 ± 11.08 versus 135.96 ± 4.3/mm2). Conclusion: Our findings demonstrate that diabetes is associated with reduced capillary density in the heart and PPARγ activation by Rosiglitazone could not alter angiogenesis in diabetic and non-diabetic rats.
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