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Aptamers, the Bivalent Agents As Probes and Therapies for Coronavirus Infections: A Systematic Review Publisher Pubmed



Torabi R1 ; Ranjbar R2 ; Halaji M3 ; Heiat M4
Authors
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Authors Affiliations
  1. 1. Laboratory of Bioanalysis, Institute of Biochemistry & Biophysics, Tehran University, Tehran, Iran
  2. 2. Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
  3. 3. Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Baqiyatallah Research Center for Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, Iran

Source: Molecular and Cellular Probes Published:2020


Abstract

The recently known coronavirus, SARS-CoV-2, has turn into the greatest global health challenge, affecting a large number of societies. The lack of specific treatment and gold-standard diagnostic system has made the situation more complicated. Efforts have led to production of several diagnostic kits that are associated with limitations such as inadequate sensitivity and accuracy. Aptamers as multipotent biological probes could be promising candidates to design sensitive and specific biosensors. Although few studies have introduced specific aptamer types of coronavirus, they may help us select the best approach to obtain specific aptamers for this virus. On the other hand, some of already-introduced aptamers have shown the inhibitory effects on coronavirus that could be applied as therapeutics. The present study has provided a systematic overview on use of aptamer-based biosensors and drugs to diagnose and treat coronavirus. © 2020 Elsevier Ltd
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