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[18F]Fdg Brain Pet and Clinical Symptoms in Different Autoantibodies of Autoimmune Encephalitis: A Systematic Review Publisher Pubmed



Nabizadeh F1, 2, 3 ; Ramezannezhad E4 ; Sardaripour A3, 5 ; Seyedi SA6 ; Salehi N7 ; Rezaeimanesh N3 ; Naser Moghadasi A3
Authors
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Authors Affiliations
  1. 1. Neuroscience Research Group (NRG), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  2. 2. School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran
  6. 6. School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  7. 7. School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Neurological Sciences Published:2022


Abstract

Introduction: Autoimmune encephalitis (AE) is caused by the antibodies that target receptors and intracellular or surface proteins. To achieve the appropriate therapeutic results, early and proper diagnosis is still the most important issue. In this review, we provide an overview of FDG-PET imaging findings in AE patients and possible relation to different subtypes and clinical features. Methods: PubMed, Web of Science, and Scopus were searched in August 2021 using a predefined search strategy. Results: After two-step reviewing, 22 studies with a total of 332 participants were entered into our qualitative synthesis. In anti-NMDAR encephalitis, decreased activity in the occipital lobe was present, in addition, to an increase in frontal, parietal, and specifically medial temporal activity. Anti-VGKC patients showed altered metabolism in cortical and subcortical regions such as striata and cerebellum. Abnormal metabolism in patients with anti-LGI1 has been reported in diverse areas of the brain including medial temporal, hippocampus, cerebellum, and basal ganglia all of which had hypermetabolism. Hypometabolism in parietal, frontal, occipital lobes, temporal, frontal, and hippocampus was observed in AE patients with anti-GAD antibodies. Conclusion: Our results indicate huge diversity in metabolic patterns among different AE subtypes and it is hard to draw a firm conclusion. Moreover, the timing of imaging, seizures, and acute treatments can alter the PET patterns strongly. Further prospective investigations with specific inclusion and exclusion criteria should be carried out to identify the metabolic defect in different AE subtypes. © 2022, Fondazione Societa Italiana di Neurologia.
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