Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effects of Concurrent Blockade of Ox2 and Cb1 Receptors in the Ventral Tegmental Area on Nicotine-Induced Place Preference in Rats Publisher Pubmed



Azizi F1 ; Fartootzadeh R1 ; Alaei H1 ; Reisi P1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Neuroscience Letters Published:2018


Abstract

In this study, the role of orexin-2 (OX2) and cannabinoid-1 (CB1) receptors and their potential interaction within the ventral tegmental area (VTA) on nicotine-induced place preference, was examined in male rats. A 5-day conditioned place preference (CPP) paradigm was used. Nicotine (0.5 mg/kg; s.c.) induced a significant CPP, without any effect on the locomotor activity during the testing phase. TCS-OX2-29 (0.4, 0.8 and 4 μg/rat), as a selective OX2 receptor antagonist and AM251 (0.2, 1 and 2 μg/rat), as a selective cannabinoid CB1 receptor antagonist, individually or simultaneously were microinjected bilaterally into the VTA. The results showed that administration of AM251 (1 and 2 μg/rat) or TCS-OX2-29 (0.4, 0.8 and 4 μg/rat) into the VTA, during the 3-day conditioning phase or testing day, could dose-dependently inhibit the development of nicotine-induced CPP, in the acquisition or expression, respectively. Concurrent administration of ineffective doses of TCS-OX2-29 and AM251 into the VTA could not affect conditioning scores. The findings of this study support the possible role of OX2 and CB1 receptors in the VTA, in the acquisition and the expression of nicotine-induced place preference. Furthermore, our data suggest that there is a possible interaction between the VTA orexinergic and cannabinoid systems in nicotine-induced place preference. © 2018 Elsevier B.V.
Related Docs
View other Related Docs
1. Electrophysiological Study of the Response of Ventral Tegmental Area Non-Dopaminergic Neurons to Nicotine After Concurrent Blockade of Orexin Receptor-2 and Cannabinoid Receptors-1, Brain Research (2019)
2. Functional Crosstalk of Nucleus Accumbens Cb1 and Ox2 Receptors in Response to Nicotine-Induced Place Preference, Neuroscience Letters (2019)
3. Mutual Assistance of Nucleus Accumbens Cannabinoid Receptor-1 and Orexin Receptor-2 in Response to Nicotine: A Single-Unit Study, Research in Pharmaceutical Sciences (2021)
4. Orexin Type-2 Receptor Blockade Prevents the Nicotine-Induced Excitation of Nucleus Accumbens Core Neurons in Rats: An Electrophysiological Perspective, Pharmacological Reports (2019)
5. Effects of Selective Orexin Receptor-2 and Cannabinoid Receptor-1 Antagonists on the Response of Medial Prefrontal Cortex Neurons to Tramadol, Synapse (2022)
6. The Effect of Orexin-2 and Endocannabinoid-1 Antagonists on Neuronal Activity of Hippocampal Ca1 Pyramidal Neurons in Response to Tramadol in Rats, Advanced Biomedical Research (2022)
7. Stimulation and Transient Inactivation of Ventral Tegmental Area Modify Reinstatement of Acquisition Phase of Morphine-Induced Conditioned Place Preference in Male Rats, Brain Research Bulletin (2021)
8. The Effect of Am281, a Cannabinoid Antagonist, on Memory Performance During Spontaneous Morphine Withdrawal in Mice, Research in Pharmaceutical Sciences (2013)
Experts (# of related papers)
View all Related Experts
Hojatallah Alaei (20)
Parham Reisi (11)
Other Related Docs
9. Effects of Angiotensin Ii and Captopril on Rewarding Propreties of Morphine, Indian Journal of Experimental Biology (2007)
10. Microinjection of a Dopamine-D1 Receptor Agonist Into the Ventral Tegmental Area Reverses the Blocked Expression of Morphine Conditioned Place Preference by N-Methyl-D-Aspartate Receptor Antagonist, Advanced Biomedical Research (2020)
11. Roles of the Nucleus Accumbens (Shell) in the Acquisition and Expression of Morphine-Induced Conditioned Behavior in Freely Moving Rats, International Journal of Preventive Medicine (2014)
12. Influences of Morphine on Cannabinoid Receptor 1, 2 Expression in Breast Cancer Cell Lines, International Journal of Women's Health and Reproduction Sciences (2024)
13. Involvement of Ampa Receptors of Lateral Habenula in the Expression and Acquisition Phases of Morphine-Induced Place Preference, Brain Research (2023)
14. An Assessment Between D1 Receptor Agonist and D2 Receptor Antagonist Into the Ventral Tegmental Area on Conditioned Place Preference and Locomotor Activity, Advanced Biomedical Research (2019)
15. The Blockade of D1 /D2-Like Dopamine Receptors in the Lateral Periaqueductal Gray Region Affects Morphine Self-Administration With and Without Exercise in Rats, Physiology and Pharmacology (Iran) (2021)
16. Effect of Electrical Stimulation of Central Nucleus of the Amygdala on Morphine Conditioned Place Preference in Male Rats, Iranian Journal of Basic Medical Sciences (2022)
17. Involvement of Basolateral Amygdala Dopamine D1 Receptors in the Acquisition and Expression of Morphine-Induced Place Preference in Rats, Advanced Biomedical Research (2022)
18. The Effect of the Blockage of the Receptors of Glutamate N-Methyl-D-Aspartate (Nmda) in Prefrontal Cortex on Morphine Tendency in Male Rat, Journal of Isfahan Medical School (2016)
19. The Electrical Stimulation of the Central Nucleus of the Amygdala in Combination With Dopamine Receptor Antagonist Reduces the Acquisition Phase of Morphine-Induced Conditioned Place Preference in Male Rat, Research in Pharmaceutical Sciences (2023)
20. The Role of Nmda Glutamate Receptors in the Lateral Habenula on Morphine-Induced Conditioned Place Preference in Rats, Synapse (2023)
21. Low Current Intensity Plus an Ineffective Dose of Morphine Affect Conditioning Place Preference Through Different Pathways in the Lateral Habenula, Advanced Biomedical Research (2023)
22. Involvement of Gabaareceptors of Lateral Habenula in the Acquisition and Expression Phases of Morphine-Induced Place Preference in Male Rats, Behavioural Pharmacology (2022)
23. The Cb1 Receptor Antagonist, Am281, Improves Recognition Loss Induced by Naloxone in Morphine Withdrawal Mice, Basic and Clinical Pharmacology and Toxicology (2012)
24. The Blockade of Glutamate N-Methyl-D-Aspartate Receptors Into the Prelimbic of Prefrontal Cortex Decreases Morphine-Induced Conditioned Place Preference in Rat, Indonesian Biomedical Journal (2017)
25. The Reinstatement of the Expression Phase of Morphine-Induced Conditioned Place Preference in Male Wistar Rats Under Ventral Tegmental Area Stimulation and Brief Inactivation, Research in Pharmaceutical Sciences (2023)
26. Am281, Cannabinoid Antagonist/Inverse Agonist, Ameliorates Scopolamine-Induced Cognitive Deficit, Iranian Journal of Basic Medical Sciences (2012)
27. Morphine and Nicotine Addiction and Withdrawal Influence Baroreflex Sensitivity and Blood Pressure in Two-Kidney One Clip Hypertensive (2K1c) Rats, Bratislava Medical Journal (2014)