Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Functional Crosstalk of Nucleus Accumbens Cb1 and Ox2 Receptors in Response to Nicotine-Induced Place Preference Publisher Pubmed



Fartootzadeh R1 ; Azizi F1 ; Alaei H1 ; Reisi P1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Neuroscience Letters Published:2019


Abstract

In the present study, we have evaluated the existence of functional interaction between orexin-2 receptor (OX2R) and cannabinoid-1 receptor (CB1R) in the nucleus accumbens core (NAcc), in nicotine-induced conditioned place preference (CPP) of Wistar male rat. Nicotine (0.5 mg/kg; s.c.) in the course of conditioning, produced a significant place preference, without any effect on the locomotor activity. Intra-NAcc administration of ineffective and effective doses of TCS-OX2-29 (2 and 6 ng/rat), a selective OX2R antagonist and AM251 (10 and 50 ng/rat), a selective CB1R antagonist, showed a significant interaction between OX2R and CB1R in the acquisition of nicotine-induced CPP (p < 0.01), and the locomotor activity (p < 0.05). No significant interaction was observed between these two receptors in the expression of nicotine-induced CPP. Our findings provide insight into the possible interaction of OX2R and CB1R of the NAcc in nicotine addiction. We propose a potential interaction between cannabinoid and orexinergic systems within the NAcc, in producing the rewarding effects. © 2019 Elsevier B.V.
Related Docs
View other Related Docs
1. Orexin Type-2 Receptor Blockade Prevents the Nicotine-Induced Excitation of Nucleus Accumbens Core Neurons in Rats: An Electrophysiological Perspective, Pharmacological Reports (2019)
2. Mutual Assistance of Nucleus Accumbens Cannabinoid Receptor-1 and Orexin Receptor-2 in Response to Nicotine: A Single-Unit Study, Research in Pharmaceutical Sciences (2021)
3. Effects of Concurrent Blockade of Ox2 and Cb1 Receptors in the Ventral Tegmental Area on Nicotine-Induced Place Preference in Rats, Neuroscience Letters (2018)
4. Electrophysiological Study of the Response of Ventral Tegmental Area Non-Dopaminergic Neurons to Nicotine After Concurrent Blockade of Orexin Receptor-2 and Cannabinoid Receptors-1, Brain Research (2019)
5. The Effect of Orexin-2 and Endocannabinoid-1 Antagonists on Neuronal Activity of Hippocampal Ca1 Pyramidal Neurons in Response to Tramadol in Rats, Advanced Biomedical Research (2022)
6. Effects of Selective Orexin Receptor-2 and Cannabinoid Receptor-1 Antagonists on the Response of Medial Prefrontal Cortex Neurons to Tramadol, Synapse (2022)
7. The Electrical Stimulation of the Central Nucleus of the Amygdala in Combination With Dopamine Receptor Antagonist Reduces the Acquisition Phase of Morphine-Induced Conditioned Place Preference in Male Rat, Research in Pharmaceutical Sciences (2023)
8. Microinjection of a Dopamine-D1 Receptor Agonist Into the Ventral Tegmental Area Reverses the Blocked Expression of Morphine Conditioned Place Preference by N-Methyl-D-Aspartate Receptor Antagonist, Advanced Biomedical Research (2020)
Experts (# of related papers)
View all Related Experts
Hojatallah Alaei (15)
Parham Reisi (11)
Other Related Docs
9. Roles of the Nucleus Accumbens (Shell) in the Acquisition and Expression of Morphine-Induced Conditioned Behavior in Freely Moving Rats, International Journal of Preventive Medicine (2014)
10. Influences of Morphine on Cannabinoid Receptor 1, 2 Expression in Breast Cancer Cell Lines, International Journal of Women's Health and Reproduction Sciences (2024)
11. Involvement of Ampa Receptors of Lateral Habenula in the Expression and Acquisition Phases of Morphine-Induced Place Preference, Brain Research (2023)
12. Effect of Electrical Stimulation of Central Nucleus of the Amygdala on Morphine Conditioned Place Preference in Male Rats, Iranian Journal of Basic Medical Sciences (2022)
13. Involvement of Basolateral Amygdala Dopamine D1 Receptors in the Acquisition and Expression of Morphine-Induced Place Preference in Rats, Advanced Biomedical Research (2022)
14. The Role of Nmda Glutamate Receptors in the Lateral Habenula on Morphine-Induced Conditioned Place Preference in Rats, Synapse (2023)
15. Low Current Intensity Plus an Ineffective Dose of Morphine Affect Conditioning Place Preference Through Different Pathways in the Lateral Habenula, Advanced Biomedical Research (2023)
16. The Blockade of Glutamate N-Methyl-D-Aspartate Receptors Into the Prelimbic of Prefrontal Cortex Decreases Morphine-Induced Conditioned Place Preference in Rat, Indonesian Biomedical Journal (2017)
17. The Reinstatement of the Expression Phase of Morphine-Induced Conditioned Place Preference in Male Wistar Rats Under Ventral Tegmental Area Stimulation and Brief Inactivation, Research in Pharmaceutical Sciences (2023)
18. Morphine and Nicotine Addiction and Withdrawal Influence Baroreflex Sensitivity and Blood Pressure in Two-Kidney One Clip Hypertensive (2K1c) Rats, Bratislava Medical Journal (2014)
19. Lateral Habenula Electrical Stimulation With Different Intensities in Combination With Gabab Receptor Antagonist Reduces Acquisition and Expression Phases of Morphine-Induced Cpp, Neuroscience Letters (2021)