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Vitamin D Deficiency in Patients With Retinal Vein Occlusion: A Systematic Review and Meta-Analysis Publisher



Daneshvar K1 ; Akhlaghi M2 ; Iranpour S1 ; Irajpour M2, 3 ; Pourazizi M2, 3
Authors
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Authors Affiliations
  1. 1. Isfahan Eye Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Isfahan Eye Research Center, Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Ophthalmology, Feiz Hospital, Modares St, Isfahan, Iran

Source: International Journal of Retina and Vitreous Published:2024


Abstract

Background: This review aims to substantiate the correlation between vitamin D and retinal vein occlusion (RVO) within the medical literature. Method: A systematic review and meta-analysis were conducted in PubMed, SCOPUS, Web of Science, and Embase until December 10th, 2023. A meticulous literature search was undertaken to identify and analyze all observational-analytical papers reporting vitamin D levels in RVO patients. The principal outcome measures centered on the comparative assessment of vitamin D levels between patients with RVO (cases) and those devoid of RVO (controls). The protocol was registered in PROSPERO (code: CRD42024499853). Results: A total of six relevant studies consisting of 589 participants were included in this meta-analysis. The results indicated a significant association between vitamin D deficiency and increased risk of RVO (Odds ratio = 14.51; 95% CI: [1.71, 122.59], P = 0.014); and patients with RVO exhibited a significant decrease in serum vitamin D levels by 1.91ng/mL (95% CI: [-2.29, -1.54], P < 0.001). Moreover, there was no significant difference observed in vitamin D levels between central RVO (CRVO) and branch RVO (BRVO) subtypes (P = 0.63). Conclusion: RVO patients have more vitamin D deficiency than healthy controls. These results contribute to the growing body of evidence highlighting the intricate role of vitamin D supplementation as both a prophylactic and a treatment strategy in RVO. PROSPERO registration identifier: : CRD42024499853. © The Author(s) 2024.
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