Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Effect of Vitamin D Supplementation on Type 2 Diabetes Biomarkers: An Umbrella of Interventional Meta-Analyses Publisher

Summary: Study finds vitamin D improves diabetes biomarkers. Could it aid management? #Type2Diabetes #VitaminD

Musazadeh V1, 2 ; Kavyani Z1, 2 ; Mirhosseini N3 ; Dehghan P4, 5 ; Vajdi M6
Authors

Source: Diabetology and Metabolic Syndrome Published:2023


Abstract

Background: Vitamin D supplementation exerts several supporting effects on improving glycemic status, however, results are inconclusive. Thus, in the present study, we aimed to conduct an umbrella of meta-analysis regarding the impact of vitamin D on type 2 diabetes (T2DM) biomarkers. Methods: The Scopus, PubMed, Web of Science, Embase, and Google Scholar online databases were searched up to March 2022. All meta-analyses evaluating the impact of vitamin D supplementation on T2DM biomarkers were considered eligible. Overall, 37 meta-analyses were included in this umbrella meta-analysis. Results: Our findings indicated that vitamin D supplementation significantly decreased fasting blood sugar (FBS) (WMD = − 3.08; 95% CI: − 3.97, − 2.19, p < 0.001, and SMD = − 0.26; 95% CI: − 0.38, − 0.14, p < 0.001), hemoglobin A1c (HbA1c) (WMD = − 0.05; 95% CI: − 0.10, − 0.01, p = 0.016, and SMD = − 0.16; 95% CI: − 0.27, − 0.05, p = 0.004), insulin concentrations (WMD = − 2.62; 95% CI: − 4.11, − 1.13; p < 0.001, and SMD = − 0.33; 95% CI: − 0.56, − 0.11, p = 0.004), and homeostatic model assessment for insulin resistance (HOMA-IR) (WMD = − 0.67; 95% CI: − 1.01, − 0.32, p < 0.001, and SMD = − 0.31; 95% CI: − 0.46, − 0.16, p < 0.001). Conclusion: This umbrella meta-analysis proposed that vitamin D supplementation may improve T2DM biomarkers. © 2023, The Author(s).
Other Related Docs
4. The Effects of Oral Vitamin D on Insulin Resistance in Pre-Diabetic Patients, Journal of Research in Medical Sciences (2013)
5. Is the Association Between Vitamin D and Metabolic Syndrome Independent of Other Micronutrients?, International Journal for Vitamin and Nutrition Research (2015)
20. Vitamin D Deficiency and Coronary Artery Disease, Journal of Research in Medical Sciences (2012)