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Effect of Extremely Low-Frequency (50 Hz) Field on Proliferation Rate of Human Adipose-Derived Mesenchymal Stem Cells



Salimi M1 ; Shahbazigahrouei D2 ; Karbasi S2 ; Kermani S2 ; Razavi S3
Authors
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Authors Affiliations
  1. 1. Department of Medical Physics and Medical Engineering, School of Medicine and Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Medical Physics and Medical Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2013

Abstract

Background: The effects of non-ionizing extremely low-frequency electromagnetic fields (ELF-EMF) chronic exposure on human beings due to its potential health hazards has become a focus of interest since many years ago. Stem cells are useful models for assessment of effects of ELF-EMF on other cell lines and human beings. Adipose tissue has been known source of multipotent stromal cells (MSCs), which can be obtained by a less invasive method and in large amounts compared with bone marrow stromal cells (BMSCs); so this study was done on human adipose-derived stem cells (hADSCs). The effect of ELF-EMF with intensity of 0.5 and 1 mT and 50 Hz on proliferation rates of hADSCs at 20 and 40 min/day for 7 days was assessed. Methods: MTT assay was used to determine the growth and metabolism of cells and Trypan blue test was also done for cell viability. Findings: The proliferation rate and growth of hADSCs in all exposure groups was significantly higher than that in sham groups except in group of 1 mT, 40 min/day (P<0.05). Conclusion: The results showed that 0.5 and 1 mT magnetic strength fields can promote the proliferation rates of the hMSCs derived adipose tissue regarding the duration of exposure.
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