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Overview of Retinal Differentiation Potential of Mesenchymal Stem Cells: A Promising Approach for Retinal Cell Therapy Publisher Pubmed



Salehi H1 ; Amirpour N1 ; Razavi S1 ; Esfandiari E1 ; Zavar R2
Authors
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Authors Affiliations
  1. 1. Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Cardiology, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Annals of Anatomy Published:2017


Abstract

Retinal disease caused by retinal cell apoptosis leads to irreversible vision loss. Stem cell investigation efforts have been made to solve and cure retinal disorders. There are several sources of stem cells which have been used in these experiments. Numerous studies demonstrated that transplanted stem cells can migrate into and integrate in different layers of retina. Among these, mesenchymal stem cells (MSCs) were considered a promising source for cell therapy. Here, we review the literature assessing the potential of MSCs to differentiate into retinal cells in vivo and in vitro as well as their clinical application. However, more investigation is required to define the protocols that optimize stem cell differentiation and their functional integration in the retina. © 2016 Elsevier GmbH
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