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The Effect of Melanocyte Cell Suspension in Jokliks Medium in the Treatment of Stable Resistant Vitiligo: Report of 10 Cases



Nilforoushzadeh MA1 ; Jaffary F2 ; Haftbaradaran E3 ; Nasresfahani MH4
Authors
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Authors Affiliations
  1. 1. Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan AND Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Rooyan Institute, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2015

Abstract

Background: Vitiligo is a cosmetically disfiguring acquired depigmenting disorder caused by the loss of functional melanocytes in the epidermis. Various approaches used for the treatment of vitiligo can be classified as medical and surgical therapies. Non-cultured autologous melanocyte transplantation is a new and effective surgical treatment for stable vitiligo. This study aimed to evaluate the effect of the melanocyte cell suspension in Jokliks medium in the treatment of stable resistant vitiligo. Methods: Ten patients with stable vitiligo, resistant to standard treatment, underwent the treatment via melanocyte cell suspension in Jokliks medium. The repigmentation was assessed during 3 weeks, and 3 and 6 months. Findings: The mean repigmentation of 10 patients with 16 lesions was 14% in 3 weeks, 37% in 3 month and 42% in 6 month that was poor repigmentation (less than 50%). Conclusion: Results of this pilot study showed less than 50% repigmentation using melanocyte cell suspension in Jokliks medium, especially in light skin type patients, without using adjunct treatments like phototherapy. © 2015, Isfahan University of Medical Sciences(IUMS). All Rights Reserved.
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