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The Efficacy of an Innovative Method of Melanocytes-Keratinocytes Suspension for the Treatment of Stable Vitiligo (A Report of 20 Cases)



Jaffary F1 ; Nilforoushzadeh MA2 ; Haftbaradaran E1 ; Zolfagharibaghbaderani A1 ; Mollabashi Z1
Authors
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Authors Affiliations
  1. 1. Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran and Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2016

Abstract

Background: Vitiligo is the most common chronic depigmentation disorder caused by melanocyte loss in the basal epidermis. Drug therapy and surgical procedures are two main modalities for its treatment and one of the most effective surgical procedures is non-cultured epidermal cell transplantation suspension containing melanocytes and keratinocytes cells. This pilot study evaluates the effectiveness of an innovative method of melanocyte-keratinocyte cell suspension for treatment of patients with stable vitiligo. Methods: Twenty patients with stable vitiligo which where resistant to standard treatment participated in this study. Melanocyte- keratinocyte cell suspension (with Patent No. 81687 method) was transferred to the affected lesions. Repigmentation of the lesions was scored as excellent, good, fair or weak by comparing lesion photos before and 6 months after the treatment. Findings: Mean repigmentation score was excellent in 1(5%), good in 4(20%), fair in 11(55%) and weak in 4 (20%) of the patients 6 months after the intervention. Conclusion: The results of this study demonstrated that melanocyte-keratinocyte cell suspension can provide good results and repigmentation in more than 50% of cases. © 2016, Isfahan University of Medical Sciences(IUMS). All Rights Reserved.
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