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Microrna: Relevance to Stroke Diagnosis, Prognosis, and Therapy Publisher Pubmed



Mirzaei H1 ; Momeni F2 ; Saadatpour L3 ; Sahebkar A4 ; Goodarzi M5 ; Masoudifar A6 ; Kouhpayeh S7 ; Salehi H8 ; Mirzaei HR9 ; Jaafari MR10
Authors
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Authors Affiliations
  1. 1. Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Neurology, University of Florida College of Medicine, Gainesville, FL, United States
  4. 4. Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  5. 5. Faculty of Bioscience Engineering, Department of Biosystems, Katholieke Universiteit Leuve—KULeuven, Heverlee, Belgium
  6. 6. Department of Molecular Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
  7. 7. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  9. 9. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Nanotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Journal of Cellular Physiology Published:2018


Abstract

Stroke is a life-threatening disease that accounts for a considerable burden of mortality in both developing and developed world. Identification of specific biomarkers for stroke and its outcomes can greatly contribute to improved care of patients. MicroRNAs (miRNAs) are known as novel biomarkers that could be used as diagnostic, prognostic, and therapeutic biomarkers. Various studies have shown that miRNAs have key roles in the pathogenesis of stroke, and its complications and outcomes. In addition, there is evidence showing that mesenchaymal stromal cell-derived exosomes containing miRNAs can be used for monitoring and treatment of various diseases such as stroke. Here, we summarized various aspects of miRNA applications in different stages of stroke. © 2017 Wiley Periodicals, Inc.
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