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Microrna Profiles in Critically Ill Patients Publisher Pubmed



Alikiaii B1 ; Bagherniya M2, 3 ; Askari G2, 3 ; Rajendram R4, 5 ; Sahebkar A6, 7, 8
Authors
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Authors Affiliations
  1. 1. Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sci-ences, Isfahan, Iran
  4. 4. Department of Medicine, King Abdulaziz Medical City, King Abdulaziz International Medical Research Center, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia
  5. 5. College of Medicine, King Saud bin Abdulaziz University of Health Sciences, Riyadh, Saudi Arabia
  6. 6. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Current Medicinal Chemistry Published:2024


Abstract

The use of biomarkers to expedite diagnosis, prognostication, and treatment could significantly improve patient outcomes. The early diagnosis and treatment of critical illnesses can greatly reduce mortality and morbidity. Therefore, there is great interest in the discovery of biomarkers for critical illnesses. Micro-ribonucleic acids (miRNAs) are a highly conserved group of non-coding RNA molecules. They regulate the expression of genes involved in several developmental, physiological, and pathological process-es. The characteristics of miRNAs suggest that they could be versatile biomarkers. Assay panels to measure the expression of several miRNAs could facilitate clinical decision--making for a range of diseases. We have, in this paper, reviewed the current understanding of the role of miRNAs as biomarkers in critically ill patients. © 2024 Bentham Science Publishers.
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