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Heterogeneity in Resistant Fecal Bacteroides Fragilis Group Collected From Healthy People Publisher Pubmed



Narimani T1 ; Douraghi M2 ; Owlia P3 ; Rastegar A1 ; Esghaei M4 ; Nasr B5 ; Talebi M1
Authors
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Authors Affiliations
  1. 1. Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Microbiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Molecular Microbiology Research Center(MMRC), Shahed University, Tehran, Iran
  4. 4. Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Microbiology, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Microbial Pathogenesis Published:2016


Abstract

Normal nonpathogenic flora would represent a constant lake of resistance genes potentially transferable to human pathogens. To assess the prevalence of resistance genes and genetic variability of Bacteroides fragilis group (BFG) from normal flora, 177 Bacteroides isolates obtained from the fecal samples of healthy individuals. These isolates were subjected to antibiotic susceptibility testing and pulsed field gel electrophoresis (PFGE). The isolates were further tested for the presence of ermF, tetQ and bft genes by PCR. Our results indicated the presence of different clonal strains (1 common type and 57 single types) among the resistant isolates. The resistance rate for the six antibiotics in this study was between 1% and 95%. Most of the isolates (99%) were susceptible to metronidazole. ermF and tetQ were detected in all erythromycin and tetracycline resistant isolates. None of the isolates were carried bft gene. These data suggest dissemination of heterogenic clonal groups in healthy persons and resistance to 5 high commonly used antibiotics. © 2016 Elsevier Ltd.
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