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Molecular Epidemiology and Mechanisms of Antimicrobial Resistance in Pseudomonas Aeruginosa Isolates Causing Burn Wound Infection in Iran Publisher Pubmed



Fazeli H1 ; Sadighian H1, 2 ; Esfahani BN1 ; Pourmand MR3
Authors
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Authors Affiliations
  1. 1. Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Iran
  2. 2. Urology Research Center, Sina Hospital, Tehran, Iran
  3. 3. Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Iran

Source: Journal of Chemotherapy Published:2014


Abstract

In this study, the contributions of different resistance mechanisms in Pseudomonas aeruginosa isolates were investigated among burned patients. The real-time reverse transcription polymerase chain reaction was performed to determine the expression level of mexY, ampC, and oprD for isolates. Also the isolates were typed by multilocus sequence typing (MLST). Seventy-five per cent of clinical isolates were multidrug resistant. The blaOXA group-I and blaPER alleles were identified in 28 and 10 P. aeruginosa isolates, respectively. The majority of blaPER positive isolates belonged to the same MLST clone and was identified as ST235. The types of remaining isolates were ST360 and ST861. Among 10 blaPER positive isolates, eight isolates demonstrated reduced oprD expression and mexY overexpression. Our data further highlight the epidemic potential of the international clone ST235. According to the results, different resistant mechanisms identified among ST235 isolates that were resistant to ceftazidime, imipenem, ciprofloxacin, and amikacin. © 2014 Edizioni Scientifiche per l'Informazione su Farmaci e Terapia.
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