Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Comparison of the Preventive Effect of Ketamine, Paracetamol and Metoclopramide on Postoperative Pain Intensity in General Anesthesia: A Double-Blind Clinical Trial



Moradi Farsani D1 ; Safari M2 ; Heidari SM1 ; Shafa A1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Anesthesiology, Medical School, Isfahan university of medical science, Isfahan, Iran
  2. 2. Medical School, Isfahan University of Medical Science, Isfahan, Iran

Source: Scientific Journal of Kurdistan University of Medical Sciences Published:2019

Abstract

Background and Aim: Postoperative pain is one of the most common complications after eye surgeries, especially cataract. Use of analgesic drugs before surgery can be effective in decreasing the pain. The purpose of this study was to investigate preemptive effect of ketamine, paracetamol, and metoclopramide on the postoperative pain in the patients following cataract surgery with general anesthesia. Materials and Methods: In this double-blind clinical trial, 80 adult patients who were candidate for cataract surgery were randomly divided into four groups. Every one of the groups received one of the following prescriptions: 0.1 mg/kg metoclopramide, 0.2 mg/kg ketamine, 1 g paracetamol and placebo before induction of anesthesia. Postoperative pain severity (based on visual analogue scale) and complications were evaluated in the groups. Results: There was a significant difference between the groups in regard to postoperative pain in the recovery room and 2 hours after the operation (P<0.05), but no significant difference was found at 8 and 24 hours after operation. Also, there was no significant difference between the groups in relation to the need for analgesic drugs for pain relief and anti emetic medications to control nausea and vomiting after surgery (P> 0.05). Conclusion: Use of metoclopramide, ketamine, and acetaminophen can lead to prevention of postoperative pain and decreased need for analgesics in the patients following cataract surgery with general anesthesia. © 2019, Kurdistan University of Medical Sciences. All rights reserved.
Related Docs
View other Related Docs
1. Comparison Between the Effects of Acetaminophen, Dexmedetomidine, and Normal Saline Infusion on Pain Severity After Cataract Surgery, Advanced Biomedical Research (2022)
2. Comparing the Effects of Ketamine Alone and in Combination With Metoclopramide on Postoperative Pain, Journal of Isfahan Medical School (2013)
3. Effects of Age and Gender on Acute Postoperative Pain After Cataract Surgery Under Topical Anesthesia and Sedation, Journal of Isfahan Medical School (2017)
4. Comparative Study of Preemptive Ketorolac and Tetracaine Eye Drops on the Need for Sedatives and Analgesics During and After Cataract Surgery, Koomesh (2022)
5. The Effect of Subcutaneous Injection of Metoclopramide, Pethidine, and Ketamine on Postoperative Pain After Inguinal Hernia Repair Under General Anesthesia, Journal of Isfahan Medical School (2020)
6. The Effect of Adding Metoclopramide to Subcutaneous Lidocaine on Postoperative Pain After Lower Abdominal Surgery With General Anesthesia, Journal of Isfahan Medical School (2011)
7. Comparing the Effect of Preemptive Intravenous Acetaminophen and Ketamine on Postoperative Pain, Journal of Isfahan Medical School (2015)
8. Pre-Incisional Analgesia With Intravenous or Subcutaneous Infiltration of Ketamine Reduces Postoperative Pain in Patients After Open Cholecystectomy: A Randomized, Double-Blind, Placebo-Controlled Study, Pain Medicine (2011)
Experts (# of related papers)
View all Related Experts
Mohammad Reza Safavi (23)
Azim Honarmand (23)
Other Related Docs
9. Influence of Pre-Emptive Versus Preventive Analgesia With Oral Acetaminophen on Postoperative Pain in Painful Ophthalmic Surgeries: Which One Is Better?, Journal of Research in Medical Sciences (2007)
10. Remifentanil-Ketamine Versus Fentanyl-Ketamine Sedation in Patients Undergoing Phacoemulsification With Topical Anesthesia: Comparison of Intraocular Pressure Changes and Sedation Quality, Journal of Research in Medical Sciences (2008)
11. Sedation Quality of Low–Dose Ketamine Combined With Dexmedetomidine Versus Propofol in Phacoemulsification Under Local Anesthesia, Pakistan Journal of Ophthalmology (2023)
12. Preemptive Low-Dose of Ketamine Does Not Effective on Anesthetic Consumption, Perioperative Analgesic Requirement and Postoperative Pain, Nausea and Vomiting in Painful Ophthalmic Surgery, Journal of Research in Medical Sciences (2013)
13. Effects of Diclofenac Drops and Artificial Tear Drops on Pain Reduction After Cataract Surgery: A Comparative Study, Journal of Isfahan Medical School (2012)
14. Impact of Preemptive Methadone or Paracetamol in Controlling Pain After Lower Abdomen Surgery Under General Anesthesia, Journal of Isfahan Medical School (2018)
15. Comparative Controlled Study of Preventive Effect of Combinations of Ketamine and Metoclopramide Vs Ketamine and Paracetamol on Postoperative Pain, Journal of Isfahan Medical School (2018)
16. The Comparison of Preemptive Effects of Propofol, Remifentanil and Ketamine on Post-Operative Pain Scores and Analgesic Requirements in Elective Lower Abdominal Surgery Under General Anesthesia: A Randomized, Double-Blinded Study, Journal of Research in Medical Sciences (2013)
17. Magnesium Sulphate Pretreatment to Alleviate Pain on Propofol Injection: A Comparison With Ketamine or Lidocaine, Acute Pain (2008)
18. The Comparison of the Efficacy and Safety of Sedation With Etomidate- Fentanyl Versus Ketamine-Midazolam Combinations in Cataract Surgery, Journal of Isfahan Medical School (2012)
19. The Effect of Intracameral Lidocaine Injection on Hemodynamic Parameters and Pain Intensity During and After Cataract Surgery Under Intravenous Sedation and Topical Anesthesia, Journal of Isfahan Medical School (2021)
20. Comparison of the Effectiveness of Intranasal Ketamine Compared With Intravenous Ketamine in Controlling Pain During Cataract Surgery, Tehran University Medical Journal (2022)
21. Effects of Lidocaine on Reducing the Need for Anesthetic Drugs During Ophthalmologic Surgeries, Journal of Isfahan Medical School (2013)
22. Comparison of the Effect of Adding Ketamine to Sodium Thiopental and Propofol on the Quality of Sedation in Cataract Surgery With Phacoemulsification Under Local Anesthesia and Intravenous Sedation; [مقایسه‌ی اثر افزودن کتامین به سدیم تیوپنتال و پروپوفول بر کیفیت آرام‌بخشی در جراحی آب مروارید با فیکوامولسیفیکاسیون تحت بی‌حسی موضعی و آرام‌بخشی داخل وریدی], Journal of Isfahan Medical School (2024)
23. Effect of Different Doses of Paracetamol on Postoperative Pain After Gynecologic Laparoscopy, International Journal of Women's Health and Reproduction Sciences (2018)
24. Comparison of the Preemptive Effect of Intravenous Paracetamol and Ketorolac on Prevention of Postoperative Pain in Patients Undergoing Abdominal Surgery, Journal of Isfahan Medical School (2017)
25. Evaluation of the Effect of Preemptive Intravenous Paracetamol on Perioperative Pain in Coronary Artery Bypass Graft Surgery, Journal of Isfahan Medical School (2016)
26. Comparing the Quality of Topical Anesthesia With Warmed or Cold Tetracaine in Cataract Surgery, Journal of Isfahan Medical School (2013)
27. Comparing the Effects of Fentanyl and Sufentanil on Hemodynamic Parameters and Acute Pain Intensity After Deep Vitrectomy Surgery, Journal of Isfahan Medical School (2018)
28. The Effect of Ketorolac and Naphazoline-Antazoline Eye Drops on Ocular Complaints After Cataract Surgery, Tehran University Medical Journal (2022)
29. Comparison of Continuous Infusions of Ketorolac, Paracetamol and Parecoxib for Postoperative Pain Management in Orthopedic Lower Limb Surgery Undergoing Spinal Anesthesia, Journal of Cellular and Molecular Anesthesia (2019)
30. A Comparative Study on the Effect of Preemptive Ketamine and Paracetamol in the Control of Postoperative Pain in Lumbar Disc Herniation Surgeries Under Spinal Anesthesia, Journal of Isfahan Medical School (2018)
31. Comparison of the Prophylactic Effect of Intravenous Ibuprofen and Intramuscular Piroxicam on Pain Severity After Lower Abdominal Surgery; [مقایسه ی تأثیر پیشگیرانه ی ایبوپروفن وریدی و پیروکسیکام عضلانی بر شدت درد بعد از عمل جراحی قسمت تحتانی شکم تحت بیهوشی عمومی], Journal of Isfahan Medical School (2022)
32. Effects of Adding Subconjunctival Block to Intravenous Sedation and Topical Anesthesia for Phacoemulsification Surgery on Intraoperative Pain, Patient Cooperation, and Patient and Surgeon Satisfaction, Journal of Isfahan Medical School (2013)
33. Efficacy of Pre-Incisional Subcutaneous Infiltration of Low-Dose Ketamine on Postoperative Pain After Cesarean Section, Pakistan Journal of Medical Sciences (2011)
34. The Preventive Effect of Intramuscular Ketamine and Methadone on Postoperative Pain After Laparoscopic Cholecystectomy, Journal of Isfahan Medical School (2017)
35. The Preventative Analgesic Effect of Preincisional Peritonsillar Infiltration of Two Low Doses of Ketamine for Postoperative Pain Relief in Children Following Adenotonsillectomy. a Randomized, Double-Blind, Placebo-Controlled Study, Paediatric Anaesthesia (2008)
36. Comparison of the Effects of Two Drug Combinations Metoclopramide-Acetaminophen, and Metoclopramide-Ketamine on Postoperative Pain, Nausea, and Vomiting After Deep Vitrectomy Surgery-A Randomized Controlled Clinical Trial, Koomesh (2022)
37. Comparative Study of the Effects of Pre-Emptive Use of Intravenous Lidocaine and Intramuscular Piroxicam on Muscular Pain After Lower Abdominal Surgery Under the General Anesthesia, Journal of Isfahan Medical School (2017)
38. Effect of Oral Ketamine on the Postoperative Pain and Analgesic Requirement Following Orthopedic Surgery, Acta Anaesthesiologica Taiwanica (2006)
39. Comparison Between the Effects of Propofol-Ketamine and Propofol-Fentanyl for Sedation in Cataract Surgery, Scientific Journal of Kurdistan University of Medical Sciences (2019)
40. Effect of Preemptive and Preventive Acetaminophen on Postoperative Pain Score: A Randomized, Double-Blind Trial of Patients Undergoing Lower Extremity Surgery, Journal of Clinical Anesthesia (2013)
41. Comparing the Preventive Effect of Combination of Ketamine With Metoclopramide or Fentanyl on the Postoperative Pain After Laparoscopic Cholecystectomy Under General Anesthesia, Journal of Isfahan Medical School (2015)
42. Preincisional Administration of Intravenous or Subcutaneous Infiltration of Low-Dose Ketamine Suppresses Postoperative Pain After Appendectomy, Journal of Pain Research (2012)
43. Comparison the Efficacy of Pre-Emptive Oral Celecoxib With Acetaminophen in Controlling Post-Operative Pain and Nausea After Lower Limb Surgery Under General Anesthesia, Journal of Cellular and Molecular Anesthesia (2016)
44. Evaluation of the Effect of Nasal Fentanyl in Comparison With Intravenous Fentanyl in Cataract Surgery by Phacoemulsification Method, Tehran University Medical Journal (2021)
45. Comparison of the Effects of Intravenous or Subcutaneous Administration of Metoclopramide on Pain and Nausea After Lower Abdominal Surgery, Journal of Isfahan Medical School (2021)
46. Safety and Efficacy of Fentanyl Versus Pethidine in Cataract Surgery Under Propofol-Based Sedation: A Double-Blind Randomized Controlled Clinical Trial, Journal of Research in Medical Sciences (2020)
47. Comparing the Intraoperative Pain Severity in Phacoemulsification Cataract Surgery Under the Topical Anesthesia and Systemic Sedation in Patients With Hairy and Normal Eyebrow, Journal of Isfahan Medical School (2015)
48. Comparing the Effects of Magnesium Sulfate and Nitroglycerin on the Control of Hypertension During and After Cataract Surgery Under Local Anesthesia and Intravenous Sedation, Journal of Isfahan Medical School (2016)
49. Effects of Magnesium Sulfate on Pain, Nausea/Vomiting, and Anesthetic Consumption After Corneal Transplantation and Vitrectomy, Journal of Isfahan Medical School (2017)
50. Injection of Lidocaine Alone Versus Lidocaine Plus Dexmedetomidine in Impacted Third Molar Extraction Surgery, a Double-Blind Randomized Control Trial for Postoperative Pain Evaluation, Pain Research and Management (2021)