Evaluation of Preventive Effectiveness of Intravenous Paracetamol in Post Partum Pain of Elective Cesarean Delivery With Spinal Anesthesia



Jabalameli M¹ ; Goudarzi L² Show Affiliations
Source: Journal of Isfahan Medical School Published:2014

Abstract

Background: Concerning the importance of pain control after cesarean section delivery taking pain analgesic to reduce post-surgery pain is important. The aim of this study was evaluating the preventive effect of intravenous paracetamol in postpartum pain of elective cesarean delivery with spinal anesthesia. Methods: In this double-blinded clinical trial study, nulliparous pregnant women admitted to Shahid Beheshti hospital, Isfahan, Iran, for elective caesarean section in 2012 were included. 70 nulliparous women were randomly assigned and divided into two groups of 35. The patient was anesthetized in a sitting position, at the level of L3-L4.. Patients (case group) received 1 g paracetamol in 100 ml normal saline or (control group) 100 ml normal saline, in 20 minutes via injecting. The sedation score, pain (visual analogue scale), heart rate, mean amount of used analgesic (pethedine), mean, systolic and diastolic blood pressure, nausea and vomiting were observed and recorded during the surgery and recovery eah 15 minutes till 1 hour and then hourly for 24 hours after the operation in ward. For quantitative variables, Mann-Whitney and independent-t tests were used for statistical analysis. Findings: During the sugery, the incidence of vomiting and the pain were not significantly different in any time between the two groups. The mean heart rate at the 0 and 5th minutes, during the surgery, was not significantly different; but at the 15th, 30th and 45th minutes, the mean heart rate was significantly higher in the control group (P < 0.001). In recovery, at the 0, 15th, 45th and 60th minutes, the pain was significantly lower among the case group (P < 0.001). But, there was no significant difference at the 30th minute. Patient satisfaction was not significantly different in the case and control groups. Conclusion: The findings of this study indicate that the use of intravenous paracetamol is effective in reducing postoperative pain and reduces the need for drugs. © 2014, Isfahan University of Medical Sciences(IUMS). All rights reserved.