Body Weight Changes and Diabetes Mellitus Incident: A Cohort Study From the Middle East Publisher Pubmed



Salesi R¹ ; Kermanialghoraishi M² ; Sadeghi A³ ; Roohafza H⁴ ; Talaei M⁵ ; Sarrafzadegan N¹ ; Sadeghi M⁶
Source: Journal of Preventive Medicine and Hygiene Published:2023

Abstract

Objective. Obesity is a known risk factor for diabetes, but the Results. During follow-ups, 261 new cases of diabetes were effect of weight changes on the incidence of diabetes is not yet recorded, with an IR of 3401.29 per 100,000 P-Y. The highest determined. This study aims to evaluate the long-term effects of number of new cases of type 2 DM belongs to participants with weight change [based on body mass index (BMI)] on the incioverweight and obesity who had minimal BMI changes (less than dence of diabetes mellitus (DM) in a middle eastern population. 5% of their baseline BMI limits; 42 and 38 new cases, respecMethod. In the Isfahan Cohort Study (ICS) 6504 adults equal or tively). Participants who were obese at baseline and had lost more greater than 35 years of age were recruited at 2001 and were than 10% or gained 5-10% of baseline BMI were in the groups followed until 2013. Absolute BMI changes (ΔBMI) were calcuwith the highest IR [360.05 - 95% CI (239.3-541.8) and 322.39 lated by subtracting the baseline BMI from the BMI measured at - 95% CI (178.5-582.1) respectively]. There was no significant follow-ups. To compare participants with different baseline BMI association between BMI changes and the incidence of DM in the easier, relative changes in BMI were quantified as the percentage participants with normal BMI, overweight, and obesity at base-of changes from baseline. DM was assessed based on standard line in cure and adjusted models. definitions. Multivariable Cox regression was used to determine Conclusions. This study showed there was no significant associathe association between ΔBMI and the incidence of diabetes. tion between diabetes mellitus incidence and BMI changes. © Copyright by Pacini Editore Srl, Pisa, Italy.