Brca1 Promoter Methylation Status in Ovarian Cancer

Brca1 Promoter Methylation Status in Ovarian Cancer Publisher

Nikbakht M¹ ; Shabanizadeh A¹ ; Salehi M² ; Talebi A³ ; Arababadi MK⁴ ; Dahim H⁵ ; Kennedy D⁶

Source: Laboratory Medicine Published:2012

Abstract

Objective: To evaluate the methylation status of the breast cancer 1, early onset (BRCA1) promoter in ovarian cancer in Iranian patients. Methods: The BRCA1 promoter methylation status of tissue from 60 patients with Mullerian-type ovarian cancer and matched benign ovarian tissue from the same patients was evaluated using bisulfate-modified DNA in methylation-specific polymerase chain reaction (MSP CR) assays. Results: Analysis of BRCA1 promoter methylation status showed that 8 of 60 cases (13%) were methylated and 11 of 60 cases (18%) were unmethylated. Conclusion: Methylation of the BRCA1 promoter may be a risk factor or cause of ovarian cancer. © 2012 by The American Society for Clinical Pathology.

2. Evaluation of Promoter Methylation Status of Mlh1 Gene in Iranian Patients With Colorectal Tumors and Adenoma Polyps, Gastroenterology and Hepatology from Bed to Bench (2017)

3. Genomic Rearrangement Screening of the Brca1 From Seventy Iranian High-Risk Breast Cancer Families, Journal of Research in Medical Sciences (2016)

Experts (# of related papers)

Mahsa Khodadoostan (1)

Azar Naimi (1)

Style	Citing Format
MLA	Nikbakht M, et al.. "Brca1 Promoter Methylation Status in Ovarian Cancer." Laboratory Medicine, vol. 43, no. 4, 2012, pp. 18-21.
APA	Nikbakht M, Shabanizadeh A, Salehi M, Talebi A, Arababadi MK, Dahim H, Kennedy D (2012). Brca1 Promoter Methylation Status in Ovarian Cancer. Laboratory Medicine, 43(4), 18-21.
Chicago	Nikbakht M, Shabanizadeh A, Salehi M, Talebi A, Arababadi MK, Dahim H, Kennedy D. "Brca1 Promoter Methylation Status in Ovarian Cancer." Laboratory Medicine 43, no. 4 (2012): 18-21.
Harvard	Nikbakht M et al. (2012) 'Brca1 Promoter Methylation Status in Ovarian Cancer', Laboratory Medicine, 43(4), pp. 18-21.
Vancouver	Nikbakht M, Shabanizadeh A, Salehi M, Talebi A, Arababadi MK, Dahim H, et al.. Brca1 Promoter Methylation Status in Ovarian Cancer. Laboratory Medicine. 2012;43(4):18-21.
BibTex	@article{ author = {Nikbakht M and Shabanizadeh A and Salehi M and Talebi A and Arababadi MK and Dahim H and Kennedy D}, title = {Brca1 Promoter Methylation Status in Ovarian Cancer}, journal = {Laboratory Medicine}, volume = {43}, number = {4}, pages = {18-21}, year = {2012} }
RIS	TY - JOUR AU - Nikbakht M AU - Shabanizadeh A AU - Salehi M AU - Talebi A AU - Arababadi MK AU - Dahim H AU - Kennedy D TI - Brca1 Promoter Methylation Status in Ovarian Cancer JO - Laboratory Medicine VL - 43 IS - 4 SP - 18 EP - 21 PY - 2012 ER -

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