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Brca1 Promoter Methylation Status in Ovarian Cancer Publisher



Nikbakht M1 ; Shabanizadeh A1 ; Salehi M2 ; Talebi A3 ; Arababadi MK4 ; Dahim H5 ; Kennedy D6
Authors
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Authors Affiliations
  1. 1. Department of Anatomy, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Genetics, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Microbiology, Hematology, and Immunology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  5. 5. Department of Pathology, Isfahan Shahid Beheshti Hospital, Isfahan, Iran
  6. 6. School of Biomolecular and Physical Science, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Nathan, QLD, Australia

Source: Laboratory Medicine Published:2012


Abstract

Objective: To evaluate the methylation status of the breast cancer 1, early onset (BRCA1) promoter in ovarian cancer in Iranian patients. Methods: The BRCA1 promoter methylation status of tissue from 60 patients with Mullerian-type ovarian cancer and matched benign ovarian tissue from the same patients was evaluated using bisulfate-modified DNA in methylation-specific polymerase chain reaction (MSP CR) assays. Results: Analysis of BRCA1 promoter methylation status showed that 8 of 60 cases (13%) were methylated and 11 of 60 cases (18%) were unmethylated. Conclusion: Methylation of the BRCA1 promoter may be a risk factor or cause of ovarian cancer. © 2012 by The American Society for Clinical Pathology.
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